Abstract: Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: A network device (110) includes a forwarding module (230) and one or more network interfaces (240) that may be configured to transmit data units. The forwarding module (230) may be configured to identify one of the network interfaces (240) to transmit a data unit when the data unit is received by the network device (110) or generated by the network device (110), determine one of the network interfaces (240) to transmit the data unit when the data unit is ready to be transmitted by the network device (110), and forward the data unit to the determined network interface (240) for network when the determined network interface (240) is the identified network interface (240).

Abstract: A dual-mode broadband modem operative to operate in a service mode and a surveillance mode is disclosed. Generally, the dual-mode broadband modem comprises a primary communication device; a secondary communication device; a central processing unit in communication with the primary and secondary communication devices; and a memory unit in communication with the central processing unit. In the service mode, the primary communication device communicates with a broadband service provider and the central processing unit stores historical information regarding performance of the primary communication device in the memory unit. If an interruption in broadband service is detected, or the performance of the primary communication device falls below a predetermined threshold, the dual-mode broadband modem switches to surveillance mode and the secondary communication device is activated.

Abstract: Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Abstract: The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.

Abstract: A data analyzer operative to be located at a customer premises, causes the transmission of a probing signal into at least one telephone line. The data analyzer computes a parameter that represents a characteristic of at least one telephone line based upon at least a measured reflected probing signal.

Abstract: An apparatus is provided for writing reference patterns on a data storage disk of a disk drive. The disk is rotated by a spindle motor. A back EMF sense circuit generates a sequence of zero crossing signals from back EMF sensed on windings of the spindle motor over each revolution of the spindle motor. The sequence of zero crossing signals define a corresponding sequence of zero crossing periods of time between successive zero crossing signals. A Phase Locked Loop (PLL) circuit generates a timing signal in response to comparison of a feedback signal to the zero crossing signals. The PLL circuit also compensates for repeatable variation among the sequence of zero crossing periods over each revolution of the spindle motor so that the timing signal is substantially independent of the repeatable variation among the sequence of zero crossing periods. A recording pattern generator writes reference patterns on the disk in response to the timing signal as the disk is rotated by the spindle motor.

Abstract: Methods and apparatus to characterize a digital subscriber line (DSL) subscriber loop are disclosed. An example method comprises selecting a portion of a search space based on a measured transfer function response, the search space defining a plurality of combinations of transmission line parameters, and identifying a characterizing parameter of a digital subscriber line (DSL) subscriber loop from the selected portion of the search space, the characterizing parameter having an associated transfer function that substantially corresponds with the measured transfer function response.

Abstract: A method of manually overriding automatic activation of an automatic headlight control system for a motor vehicle, headlamps operable in a high beam state and a low beam state, a high/low beam switch movable from a neutral position to a latched position and from a neutral position to a non-latched position for controlling the state of the headlamps and a headlamp on/off switch comprising a multi-position switch with at least a selectively automatic headlamp position is disclosed. The system includes forward-facing sensor for collecting light emanating from for instance a second vehicle, and a controller for controlling, when the headlamp switch is detected as being in the automatic headlamp position, the headlamp states as a function of the sensed intensity of the beam of light emanating from said second vehicle.

Abstract: The control systems and technique can regulate or control operations of a water treatment system in a primary control mode and, when appropriate, in a secondary or an alternate control mode. The primary control can represent a normal control mode during which the water treatment system is intended to operate. The alternate control mode can represent a second control or mode of operation. The systems can be operated to control or facilitate regulation, monitoring, and performance of one or more operating parameters of one or more water systems between, or to and from, a first mode, a second or alternate mode, and, in some cases, a third or even a fourth control mode. The change in control mode can be triggered by identifying one or more predetermined, pre-selected, and/or programmed conditions.

Abstract: Methods and systems for operating computing devices are described. In one embodiment, a small amount of static RAM (SRAM) is incorporated into an automotive computing device. The SRAM is battery-backed to provide a non-volatile memory space in which critical data, e.g. the object store, can be maintained in the event of a power loss.

Abstract: The control systems and technique can regulate or control operations of a water treatment system in a primary control mode and, when appropriate, in a secondary or an alternate control mode. The primary control can represent a normal control mode during which the water treatment system is intended to operate. The alternate control mode can represent a second control or mode of operation. The systems can be operated to control or facilitate regulation, monitoring, and performance of one or more operating parameters of one or more water systems between, or to and from, a first mode, a second or alternate mode, and, in some cases, a third or even a fourth control mode. The change in control mode can be triggered by identifying one or more predetermined, pre-selected, and/or programmed conditions.

Abstract: In a particular embodiment a method of collecting and processing modem data is provided. The method includes, during training of a broadband modem, sending a series of tones within a frequency transmission band of the broadband modem, receiving the transmitted series of tones at a receiving broadband modem, receiving a measurement value, determining a transmission loss for each of the series of tones by comparing the predetermined transmission power level, and the received measured power level, performing a statistical match comparison between each of the received tone signals and a plurality of different computer models of a single transmission facility having various bridge taps connected to the single transmission facility, and determining a best fit between each of the received tone signals and one of the plurality of the bridge tap computer models. The series of tones have a predetermined transmission power level.

Abstract: The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.

Abstract: A preload system for bearings in a waterjet propulsion apparatus, the apparatus including a water intake section and a pumping unit including a bearing cartridge. The bearing cartridge is designed such that during operation a preload system provides tailoring between radial and axial thermal growths of a plurality of bearing components that comprise the bearing cartridge and such that an initial ambient temperature preload condition can be maintained or reduced during normal water mode operation conditions. The preload system includes a plurality of spacers that when positioned relative to the bearing components of the bearing cartridge prevent relative motion between the bearing components during land mode operation and maintain or reduce the initial ambient room temperature preload condition during normal water mode operation.

Abstract: The present invention encompasses pre-mixed formulations comprising a GLP-1 polypeptide and a basal insulin.

Abstract: Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1–C6 alkyl, C1–C6 alkoxy, C2–C6 alkenyl, C2–C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

Abstract: The present invention encompasses a GLP-1 analog and compositions and formulations thereof useful for the treatment of hyperglycemia and other various diseases and conditions in mammals.