Abstract: A road safety rail system comprising at least one continuous rail, or a plurality of sequentially connected system rails, forming a main body of a barrier, which are supported above ground by one or more ground engaging posts, wherein the system also comprises a terminal end section (TES) having an upstream end and a downstream end, the TES including: a stationary component comprising one or more standard terminal end (STE)-rails at the downstream end connected to at least one formed terminal end (FTE)-rail located at the upstream end of the TES, the STE rails being supported at a set horizontal axis height above ground level by a plurality of posts; wherein the at least one FTE-rail(s)-include(s) a twist from a primarily vertical orientation to a primarily horizontal orientation; Wherein the at least one FTE rail(s) bends down from a set horizontal axis height Y above ground level to a horizontal axis height being at, or near ground level; a moving energy absorbing component comprising an impact head incl

Abstract: The INTERIOR COMFORT HVAC USER-FEEDBACK CONTROL SYSTEM AND APPARATUS transforms qualitative feedback received from a user/occupant into a “comfort map,” or modifications thereto, a comfort map being defined at least in part by one or more comfort event windows. The comfort map data is used to determine a temperature setpoint sequence that avoids regions of the map corresponding to known and/or predicted regions of user discomfort.

Abstract: A processor-implemented method of controlling an HVAC system transforms a comfort map into a plurality of sequential constant-temperature segments that are used in generating a control temperature sequence that preserves occupant comfort while improving energy efficiency. The method balances user comfort, temperature trajectory execution complexity, operational HVAC trajectory realization, and energy efficiency. The system achieves this balance through utilization of comfort map metric data, analysis and control system execution. The system, comfort map metric data processing and analysis facilitates this balance by executing a control temperature sequence/temperature trajectories developed based on direct user comfort feedback data within the context of a comfort map and thermal equilibrium boundaries derived from the comfort map.

Abstract: Systems for examining a route inject one or more electrical examination signals into a conductive route from onboard a vehicle system traveling along the route, detect one or more electrical characteristics of the route based on the one or more electrical examination signals, and detect a break in conductivity of the route responsive to the one or more electrical characteristics decreasing by more than a designated drop threshold for a time period within a designated drop time period. Feature vectors may be determined for the electrical characteristics and compared to one or more patterns in order to distinguish between breaks in the conductivity of the route and other causes for changes in the electrical characteristics.

Abstract: A modular data center includes a base electrical module having a casing, a controller supported by the casing, and a power distribution unit coupled to the controller. The modular data center further includes an equipment rack having a frame coupled to the base electrical module, with the frame of the equipment rack being configured to receive electronic equipment. The electronic equipment receives power from the base electrical module. The base electrical module is external to the equipment rack.

Abstract: The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders.

Abstract: A system for monitoring compliance with a retail display program includes a beacon coupled to a promotional display structure. The beacon is configured to transmit a beacon signal that includes a beacon ID and is configured to be received by a user device. A database stores the beacon ID along with a specified retail facility and time period associated with the promotional display structure. A computing device is configured to receive a beacon data record at least partially generated by the user device. The beacon data record includes the beacon ID, a time stamp, and location-specific data associated with a retail facility in which the beacon data record is generated. The computing device is configured to compare the location-specific data and time stamp to the specified retail facility and time period to determine whether the promotional display structure is displayed in the specified retail facility during the specified time period.

Abstract: A method of adjusting multiple tools on a common mount includes the interrogating first and second actual target positions on at least one workpiece. A variance is determined between the first and second actual target position and first and second theoretical target positions. At least one of the first and second tools is moved relative to the other of the first and second tools from the first and second theoretical target positions to a desired spacing respectively aligned with the first and second actual target positions.

Abstract: A sonotrode includes multiple layers of a material melted to one another to form a structure. The structure provides a base that has an attachment feature that is configured to operatively secure to an ultrasonic converter. The structure includes a shaft that extends from the base to a terminal end that provides a working surface that is configured to selectively engage a workpiece.

Abstract: Disease components can be detected in a fluid using magnetic particles and microfluidics. Magnetic particles are combined with a sample in a fluid. The sample may include disease components. The magnetic particles can be configured to tag any disease components within the sample. The fluid can be forced into a microchamber with two microcompartments. In the first microcompartment, the fluid can be exposed to a magnetic field and/or magnetic field gradient. The tagged disease component can be trapped by the magnetic field and/or magnetic field gradient due to the magnetic particles, allowing nonmagnetic components of the fluid to be washed away while the tagged disease components remain trapped by the magnetic field and/or magnetic field gradient. Then, the disease components can be forced into a more narrow second microcompartment and detected using optical instruments.

Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.

Abstract: A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.

Abstract: The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders.

Abstract: A fluid processing system includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a spinning membrane separator drive coupled to the spinning membrane separator, first and second syringe pumps coupled to the first and second syringes respectively, a control cassette interface coupled to the flow control cassette, and at least one controller coupled to the spinning membrane separator drive, the first and second syringe pumps, and the control cassette interface. The controller is configured to selectively operate the drive, the first and second syringe pumps, and the interface to provide a procedure according to a protocol.

Abstract: Embodiments of the disclosure provide a thermal model based on an adaptive filter bank for characterizing heat transfer of a volume of a thermal system. In one embodiment, the adaptive filter bank is used for diagnostics that provides information related to the condition of a thermal system. The diagnostics are based on an analysis of heat transfer characteristics of a dynamic representation of the thermal system. In accordance with the embodiments, thermal coefficients are generated based on an adaptive filter bank. One or more filters are applied to the thermal coefficients based on a sampling rate and one or more estimate thermal coefficient thresholds are generated based on the sampling rate. It is determined whether at least one of the thermal coefficients that is filtered satisfies at least one of the estimated thermal coefficient thresholds. Thereupon, alert information indicative of a diagnostic event is provided based on the determination.

Abstract: A frame error correction circuit may identify and correct errors in data frames provided to a receiver as part of a diversity communications scheme. The frame error correction circuit may further align the data frames so that the data frames can be compared. The frame error correction circuit may perform a bit-wise comparison of the data frames and identify inconsistent bit positions where bits in the data frames differ from one another. Once inconsistent bit positions have been identified, the frame error correction circuit may access a permutation table of permutations of bits at the inconsistent bit positions. In some implementations, the frame error correction circuit uses the permutation table to reassemble permutations of the data frames. In various implementations, the frame error correction circuit performs a CRC of each permutation of the data frames, and provides a valid permutation to a network.

Abstract: A method of adjusting multiple tools on a common mount includes the interrogating first and second actual target positions on at least one workpiece. A variance is determined between the first and second actual target position and first and second theoretical target positions. At least one of the first and second tools is moved relative to the other of the first and second tools from the first and second theoretical target positions to a desired spacing respectively aligned with the first and second actual target positions.

Abstract: A system, method, and apparatus are discussed for a passive optical camera-based system to detect a presence of one or more vehicles with one or more cameras. A detection algorithm is applied to recognize of the presence of the one or more vehicles using one or more imaging processors and the one or more cameras to detect fluctuations in light intensity from scattered light and/or reflections off of that vehicle. Those scattered light and/or reflections are captured in images contained in a set of frames from the one or more cameras.

Abstract: A steering system for a vehicle includes a housing, an input shaft, and a hybrid shaft support. The housing defines an opening. The input shaft is configured to rotate about an input axis. The hybrid shaft support may be disposed at the opening and configured to couple the input shaft to the housing. The hybrid shaft support may also be configured to support the input shaft as the input shaft rotates. The hybrid shaft support further includes a cylindrical member and a flexible seal over-molded onto the cylindrical member.

Abstract: A vehicle includes a low-voltage battery electrically coupled to a powertrain, and a computer programmed to put the vehicle in a minimal risk condition in response to a state of charge of the low-voltage battery falling below a threshold. The vehicle may further include a DC/DC converter electrically coupled to the powertrain and to the low-voltage battery, and a high-voltage battery electrically coupled to the powertrain.