Patents by Inventor Robert A. Kastelein

Robert A. Kastelein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding IL-174
    Patent number: 7625720
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: December 1, 2009
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • MAMMALIAN CYTOKINES; RECEPTORS; RELATED REAGENTS AND METHODS
    Publication number: 20090275135
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: June 29, 2009
    Publication date: November 5, 2009
    Inventors: PEDRO A. RECHE-GALLARDO, VASSILI SOUMELIS, YONG-JUN LIU, RENE DE WAAL MALEFYT, J. FERNANDO BAZAN, ROBERT A. KASTELEIN
  • Mammalian cytokines; related reagents
    Patent number: 7579440
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: August 25, 2009
    Assignee: Schering Corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Mammalian cytokines; receptors; related reagents and methods
    Patent number: 7569224
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: August 4, 2009
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassili Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian Cytokines; Related Reagents
    Publication number: 20090191569
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 30, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • IL-33 receptor
    Patent number: 7560530
    Abstract: Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33 signaling.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: July 14, 2009
    Assignee: Schering Corporation
    Inventors: Alissa A. Chackerian, Robert A. Kastelein
  • Method for the Treatment of Multiple Sclerosis by Inhibiting IL-17 Activity
    Publication number: 20090092604
    Abstract: Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
    Type: Application
    Filed: November 20, 2008
    Publication date: April 9, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Daniel J. Cua, Yi Chen, Robert A. Kastelein, Claire L. Langrish, Donna M. Rennick, Jonathon Sedgwick
  • Nucleic acids encoding DCRS5
    Patent number: 7510853
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: March 31, 2009
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Method of treating skin inflammation
    Patent number: 7501247
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: March 10, 2009
    Assignee: Schering Corporation
    Inventors: Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy
  • MAMMALIAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
    Publication number: 20090060865
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: July 28, 2008
    Publication date: March 5, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Methods of Modulating Cytokine Activity; Related Reagents
    Publication number: 20090041718
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 12, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Jochen Schmitz, Martin Oft, Robert A. Kastelein, J. Fernando Bazan
  • Use of IL-17 Expression to Predict Skin Inflammation; Methods of Treatment
    Publication number: 20090028860
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
    Type: Application
    Filed: September 2, 2008
    Publication date: January 29, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy
  • MAMMALIAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
    Publication number: 20080317748
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: July 28, 2008
    Publication date: December 25, 2008
    Applicant: SCHERING CORPORATION
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Use of Cytokine Expression to Predict Skin Inflammation; Methods of Treatment
    Publication number: 20080317749
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Application
    Filed: September 2, 2008
    Publication date: December 25, 2008
    Applicant: SCHERING CORPORATION
    Inventors: Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan
  • Method of evaluating inflammatory skin disorders using IL-17 and/or IL-19
    Patent number: 7427402
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: September 23, 2008
    Assignee: Schering Corporation
    Inventors: Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan
  • Mammalian receptor protein DCRS5;methods of treatment
    Patent number: 7422743
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: September 9, 2008
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease
    Publication number: 20080199460
    Abstract: Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity.
    Type: Application
    Filed: August 30, 2006
    Publication date: August 21, 2008
    Inventors: Daniel J. Cua, Robert A. Kastelein, Van T. Tsai, Rachel Caspi, Phyllis Silver, Dror Luger
  • HUMAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
    Publication number: 20080199477
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Application
    Filed: April 9, 2008
    Publication date: August 21, 2008
    Inventors: Gerard T. Hardiman, Fernando L. Rock, J. Fernando Bazan, Robert A. Kastelein, Stephen W.K. Ho, Yong-Jun Liu
  • Human Receptor Proteins; Related Reagents and Methods
    Publication number: 20080194800
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Application
    Filed: April 9, 2008
    Publication date: August 14, 2008
    Inventors: Gerard T. Hardiman, Fernando L. Rock, J. Fernando Bazan, Robert A. Kastelein, Stephen W.K. Ho, Yong-Jun Liu
  • DCRS5 polypeptides
    Patent number: 7411041
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: August 12, 2008
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham