Patents by Inventor Robert A. Kastelein

Robert A. Kastelein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-17-like cytokine binding compounds and antibodies
    Patent number: 6562578
    Abstract: IL-17-like cytokines from mammals, reagents and diagnostic kits related thereto including purified proteins, specific antibodies, and nucleic acids are provided. Methods of using the reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: May 13, 2003
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20030082734
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: September 18, 2002
    Publication date: May 1, 2003
    Inventors: Lynette M. Dowling, Jacqueline C. Timans, Daniel M. Gorman, Robert A. Kastelein, J. Fernando Bazan
  • Human receptor proteins; related reagents and methods
    Publication number: 20030055218
    Abstract: Nucleic acids encoding mammalian, e.g., human receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: October 22, 2001
    Publication date: March 20, 2003
    Inventors: Jacqueline C. Timans, Johannes Eduard Maria Antonius Debets, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Human receptor proteins; related reagents and methods
    Publication number: 20030032090
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Application
    Filed: September 10, 2001
    Publication date: February 13, 2003
    Applicant: Schering Corporation, a New Jersey Corporation
    Inventors: Gerard T. Hardiman, Fernando L. Rock, Bazan J. Fernando, Robert A. Kastelein, Stephen W.K. Ho, Yong-Jun Liu
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20030017617
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: May 10, 2001
    Publication date: January 23, 2003
    Applicant: Schering Corporation, a New Jersey Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Mammalian cytokines; related reagents
    Publication number: 20030008343
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 22, 2001
    Publication date: January 9, 2003
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20020173623
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: November 8, 2001
    Publication date: November 21, 2002
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; related reagents and methods
    Publication number: 20020164332
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1&dgr;, IL-1&egr;, purified IL-1&dgr; and IL-1&egr; proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 7, 2002
    Inventors: Joseph A. Hedrick, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; related reagents
    Publication number: 20020164609
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: November 30, 2001
    Publication date: November 7, 2002
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20020102234
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1&dgr;, IL-1&egr;, purified IL-1&dgr; and IL-1&egr; proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: February 1, 2001
    Publication date: August 1, 2002
    Applicant: Schering Corporation, a New Jersey Corporation
    Inventors: Johannes Eduard Maria Antonius Debets, Jacqueline C. Timans, J. Fernando Bazan, Robert A. Kastelein
  • Cytokine antagonists
    Publication number: 20020068060
    Abstract: Antagonists of a cytokine signaling system have been found which exhibit favorable properties. In particular, antibody antagonists raised against the receptor are effective in blocking various signaling processes.
    Type: Application
    Filed: April 12, 2001
    Publication date: June 6, 2002
    Inventors: Johannes Eduard Maria Antonius Debets, John S. Abrams, Robert A. Kastelein, Anne O'Garra
  • Human receptor proteins; related reagents and methods
    Patent number: 6326472
    Abstract: Nucleic acids encoding mammalian, e.g., human receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: December 4, 2001
    Assignee: Schering Corporation
    Inventors: Jacqueline C. Timans, Johannes Eduard Maria Antonius Debets, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Mutational variants of mammalian proteins
    Patent number: 6225446
    Abstract: Muteins, which are mutational variants of mammalian proteins. Particular positions of natural proteins are identified as critical in providing various different activities. Specific embodiments demonstrate properties of variations at these positions.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: May 1, 2001
    Assignee: Schering Corporation
    Inventors: Scott W. Altmann, Fernando L. Rock, J. Fernando Bazan, Robert A. Kastelein
  • BCRF1 proteins as inhibitors of interferon-.gamma.
    Patent number: 5736390
    Abstract: BCRF1 proteins are provided for treating conditions associated with excessive production of IFN-.gamma.. Also provided are expression vectors for producing BCRF1 proteins. Compositions of the invention are useful in treating a variety of disorders, including allergy, psoriasis, tissue rejection, and MHC-linked autoimmune diseases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 7, 1998
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Robert A. Kastelein
  • BCRF1 proteins as inhibitors of interferon-.gamma.
    Patent number: 5627155
    Abstract: BCRF1 proteins are provided for treating conditions associated with excessive production of IFN-.gamma.. Also provided are expression vectors for producing BCRF1 proteins. Compositions of the invention are useful in treating a variety of disorders, including allergy, psoriasis, tissue rejection, and MHC-linked autoimmune diseases.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: May 6, 1997
    Assignee: Schering Corporation
    Inventors: Kevin W. Moore, Robert A. Kastelein