Patents by Inventor Robert A. Kastelein

Robert A. Kastelein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian cytokine complexes
    Patent number: 7390481
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: June 24, 2008
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Jacqueline C. Timans, Robert A. Kastelein, J. Fernando Bazan
  • PURIFIED MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS
    Publication number: 20080090993
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 17, 2008
    Inventors: Daniel Gorman, J. Bazan, Robert Kastelein, Gerard Zurawski
  • PURIFIED MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS
    Publication number: 20080085262
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 10, 2008
    Inventors: Daniel Gorman, J. Bazan, Robert Kastelein, Gerard Zurawski
  • Human Receptor Proteins; Related Reagents and Methods
    Publication number: 20080025974
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Application
    Filed: August 23, 2007
    Publication date: January 31, 2008
    Inventors: Gerard Hardiman, Fernando Rock, J. Bazan, Robert Kastelein, Stephen Ho, Yong-Jun Liu
  • Human receptor proteins; related reagents and methods
    Patent number: 7271248
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: September 18, 2007
    Assignee: Schering Corporation
    Inventors: Gerard T. Hardiman, Fernando L. Rock, J. Fernando Bazan, Robert A. Kastelein, Stephen W. K. Ho, Yong-Jun Liu
  • METHODS OF MODULATING A MAMMALIAN CYTOKINE
    Publication number: 20070160579
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Application
    Filed: March 5, 2007
    Publication date: July 12, 2007
    Applicant: Schering Corporation
    Inventors: Jochen Schmitz, Martin Oft, Robert Kastelein, J. Bazan
  • MAMMALIAN CYTOKINE; REAGENTS AND METHODS
    Publication number: 20070141024
    Abstract: Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists or antagonists. Also provided are methods of treatment and diagnosis of immune and proliferative disorders.
    Type: Application
    Filed: January 10, 2007
    Publication date: June 21, 2007
    Inventors: Robert Kastelein, Jochen Schmitz
  • Use of cytokine expression to predict skin inflammation; methods of treatment
    Publication number: 20070098727
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Application
    Filed: December 8, 2006
    Publication date: May 3, 2007
    Inventors: Robert Kastelein, Terrill McClanahan, Erin Murphy, Jason Chan
  • Mammalian cytokines; related reagents and methods
    Patent number: 7205381
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1?, IL-1?, purified IL-1? and IL-1? proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: April 17, 2007
    Assignee: Schering Corporation
    Inventors: Joseph A. Hedrick, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
  • Purified mammalian cytokines; related reagents and methods
    Publication number: 20070065918
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: November 27, 2006
    Publication date: March 22, 2007
    Inventors: Daniel Gorman, J. Bazan, Robert Kastelein, Gerard Zurawski
  • Mammalian cytokines; related reagents and methods
    Publication number: 20070059803
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: August 10, 2006
    Publication date: March 15, 2007
    Applicant: Schering Corporation
    Inventors: Birgit Oppmann, Rene de Waal Malefyt, Donna Rennick, Robert Kastelein, Maria Wiekowski, Sergio Lira, Satwant Narula
  • Mammalian genes; related reagents and methods
    Patent number: 7183382
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: February 27, 2007
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
  • Binding compounds for IL-27
    Patent number: 7148330
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: December 12, 2006
    Assignee: Schering Corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Mammalian cytokines; related reagents and methods
    Patent number: 7090847
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: August 15, 2006
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
  • Cytokine receptor
    Patent number: 7071308
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: July 4, 2006
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Uses of mammalian cytokine; related reagents
    Publication number: 20060140950
    Abstract: Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
    Type: Application
    Filed: February 21, 2006
    Publication date: June 29, 2006
    Applicant: Schering Corporation
    Inventors: Daniel Cua, Yi Chen, Robert Kastelein, Claire Langrish, Donna Rennick, Jonathon Sedgwick
  • Uses of mammalian cytokine; related reagents
    Publication number: 20060134112
    Abstract: Provided are methods of treatment for inflammatory and autoimmune disorders of the metabolic system. Also provided are methods of diagnosis.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Applicant: Schering Corporation
    Inventors: Daniel Cua, Robert Kastelein
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20060110386
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: December 9, 2005
    Publication date: May 25, 2006
    Applicant: Schering Corporation
    Inventors: Pedro Reche-Gallardo, Vassili Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Bazan, Robert Kastelein
  • Purified mammalian cytokines; related reagents and methods
    Patent number: 7005501
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: February 28, 2006
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • Use of cytokine expression to predict skin inflammation; methods of treatment
    Publication number: 20050287593
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
    Type: Application
    Filed: September 2, 2005
    Publication date: December 29, 2005
    Applicant: Schering Corporation
    Inventors: Robert Kastelein, Terrill McClanahan, Erin Murphy, Jason Chan