Patents by Inventor Robert A. Kastelein

Robert A. Kastelein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of IL-17 expression to predict skin inflammation; methods of treatment
    Publication number: 20050244874
    Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 3, 2005
    Applicant: Schering Corporation
    Inventors: Robert Kastelein, Terrill McClanahan, Erin Murphy
  • Methods of modulating cytokine activity; related reagents
    Publication number: 20050214296
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders. Also provided are methods of administering agonists or antagonists of IL-27 and IL-27 receptor.
    Type: Application
    Filed: February 15, 2005
    Publication date: September 29, 2005
    Applicant: Schering Corporation
    Inventors: Robert Kastelein, Terrill McClanahan, Stefan Pflanz
  • Methods of modulating a mammalian cytokine
    Publication number: 20050203046
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
    Type: Application
    Filed: February 15, 2005
    Publication date: September 15, 2005
    Applicant: Schering Corporation
    Inventors: Jochen Schmitz, Martin Oft, Robert Kastelein
  • Human receptor proteins; related reagents and methods
    Publication number: 20050112659
    Abstract: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 26, 2005
    Inventors: Gerard Hardiman, Fernando Rock, J. Bazan, Robert Kastelein, Stephen Ho, Yong-Jun Liu
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20050106673
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: December 17, 2004
    Publication date: May 19, 2005
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Lynette Dowling, Jacqueline Timans, Daniel Gorman, Robert Kastelein, J. Bazan
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20050100917
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: September 18, 2003
    Publication date: May 12, 2005
    Inventors: Madaline Chirica, Robert Kastelein, Kevin Moore, Christi Parham
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20050100918
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: September 18, 2003
    Publication date: May 12, 2005
    Inventors: Madaline Chirica, Robert Kastelein, Kevin Moore, Christi Parham
  • Nucleic acids encoding a cytokine receptor complex
    Patent number: 6890734
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 10, 2005
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; related reagents and methods
    Publication number: 20050048625
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 11, 2004
    Publication date: March 3, 2005
    Inventors: Birgit Oppmann, Jacqueline Timans, Robert Kastelein, J. Bazan
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20050014199
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: August 25, 2004
    Publication date: January 20, 2005
    Applicant: Schering Corporation
    Inventors: Pedro Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Bazan, Robert Kastelein
  • Mammalian cytokines; receptors; related reagents and methods
    Patent number: 6843987
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1?, IL-1?, purified IL-1? and IL-1? proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: January 18, 2005
    Assignee: Schering Corporation
    Inventors: Johannes Eduard Maria Antonius Debets, Jacqueline C. Timans, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian receptor proteins; related reagents and methods
    Publication number: 20040258686
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: November 21, 2003
    Publication date: December 23, 2004
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Uses of mammalian cytokine; related reagents
    Publication number: 20040219150
    Abstract: Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
    Type: Application
    Filed: February 4, 2004
    Publication date: November 4, 2004
    Inventors: Daniel J. Cua, Yi Chen, Robert A. Kastelein, Claire L. Langrish, Donna M. Rennick, Jonathon Sedgwick
  • Mammalian cytokines; related reagents
    Publication number: 20040198955
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 11, 2004
    Publication date: October 7, 2004
    Applicant: Schering Corporation, a New Jersey. corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Mammalian cytokine complexes
    Patent number: 6800460
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: October 5, 2004
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Jacqueline C. Timans, Robert A. Kastelein, J. Fernando Bazan
  • Mammalian cytokines; related reagents and methods
    Publication number: 20040192891
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 11, 2004
    Publication date: September 30, 2004
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Birgit Oppmann, Jacqueline C. Timans, Robert A. Kastelein, J. Fernando Bazan
  • IL-23 receptor binding compositions
    Patent number: 6756481
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: June 29, 2004
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Purified mammalian cytokines; related reagents and methods
    Publication number: 20040122221
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: December 19, 2003
    Publication date: June 24, 2004
    Applicant: Schering Corporation, a New Jersey corporation.
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • Purified mammalian cytokines; related reagents and methods
    Publication number: 20030170827
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 14, 2003
    Publication date: September 11, 2003
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • Mammalian cytokines; related reagents and methods
    Publication number: 20030162261
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: February 27, 2003
    Publication date: August 28, 2003
    Applicant: Schering Corporation, a New Jersey corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula