Abstract: A zero trust network access appliance deployed at a customer premises can support gateway and cloud modes. In a gateway mode, the appliance operates as a zero trust network access gateway, and provides zero trust network access to applications hosted at the customer premises, using a firewall at the customer premises for network security. In the cloud mode, the appliance initiates a secure connection with a remote, cloud computing platform that provides a front end for zero trust network access. A threat management facility for the customer provides a control plane for managing zero trust network access provided through the cloud computing platform.

Abstract: Infrastructure for zero trust network access (ZTNA) is deployed as a cloud-based service remotely from a customer premises where user applications are hosted. By connecting an appliance on the customer premises to the cloud-based service through a secure tunnel or the like, an application hosted on the customer premises can then be accessed externally as a ZTNA application without the customer premises opening a firewall to public networks or otherwise exposing potential attack surfaces to the customer premises.

Abstract: A method includes receiving, by a computer system, information related to device health of an electronic device, determining, by the computer system, a health status of the electronic device based at least in part on the received information related to the device health of the electronic device, requesting, by a switch having a port connected to the electronic device, the health status of the electronic device from the computer system, receiving, by the computer system, the request for the health status of the electronic device from the switch, transmitting, by the computer system, the health status of the electronic device to the switch, evaluating, by the switch, the transmitted health status of the electronic device using network access rules associated corresponding to health statuses, and applying, by the switch, a network access control configuration to the port of the switch based on the evaluating the transmitted health status.

Abstract: Control systems for liquid lenses can use feedback control using one or more measured parameters indicative of a position of the fluid interface in the liquid lens. Capacitance between a fluid and an electrode in the liquid lens can vary depending on the position of the fluid interface. Current mirrors can be used for making measurements indicative of the capacitance and/or the fluid interface position. The liquid lens can be calibrated using the measurements indicative of capacitance and/or fluid interface position as the voltage is driven across an operational range. A control system can use pulse width modulation (PWM) for driving a liquid lens, and a carrier frequency for the PWM signals can be varied to control power consumption in the liquid lens. The slew rate can be adjustable to control power consumption in the liquid lens.

Abstract: The present disclosure relates to solid oral dosage forms comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.

Abstract: Methods for managing non-player characters and power centers in a computer game are based on character hierarchies and individualized correspondences between each character's traits or rank and events that involve other non-player characters or objects. Players may share power centers, character hierarchies, non-player characters, and related quests involving the shared objects with other players playing separate and unrelated game instances over a computer network, with the outcome of the quests reflected in different the games. Various configurations of game machines are used to implement the methods.

Abstract: The present invention relates to the development of and use of genetically modified human differentiated cells coupled with xenotransplantation into animal models to identify injury and disease-specific RNA and/or protein biomarkers. Specifically, the present invention encompasses two complementary methods for biomarker discovery that enable the direct and selective labelling, isolation, and analysis of human-specific RNA and/or proteins from xenotransplantation (or chimeric) animal models. Both methods involve the treatment of animal models with an RNA analog and/or amino acid analog that enables the specific isolation and quantification of human RNAs and/or proteins for the identification of novel human biomarkers for a large array of human injuries and diseases.

Abstract: The problem of potentially damaging a pallet layer that is gripped by clamps of a depalletizing tool is solved i) by detecting the real position of the layer using a pad on the tool that is movable with the clamps towards the pallet layer and whose detected stopping position determines the real position of the layer, and ii) while the layer is gripped by the clamp, by inserting under the layer curtains; the pressure on the layer by the clamps being adapted to the ease to go underneath the layer.

Abstract: An endoscopic system includes an endoscopic imager configured to capture image frames of a target site within a living body and a processor configured to apply a spatial transform to a preliminary set of image frames, the spatial transform converting the image frames into cylindrical coordinates; calculate a map image from the spatially transformed image frames, each pixel position in the map image being defined with a vector of fixed dimension; align a current image frame with the map image and apply the spatial transform to the current image frame; fuse the spatially transformed current image frame to the map image to generate a fused image; and apply an inverse spatial transform to the fused image to generate an enhanced current image frame having a greater spatial resolution than the current image frame. The system also includes a display displaying the enhanced current image frame.

Abstract: Methods and systems for content optimization are described. A computing device may determine a predictability score that indicates a probability that a device will access a first content item. The computing device may send a second content item associated with the first content item. The second content item may be based on the predictability score, and the predictability score may be modified. Additional content consumption and/or recommendations may be adjusted based on the predictability score.

Abstract: The present disclosure is generally directed to the use of antibodies that specifically bind one or more epitopes within a sortilin protein, e.g., human sortilin or mammalian sortilin, for treating and/or delaying progression of a disease, disorder, or injury in an individual in need thereof.

Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.

Abstract: Systems and methods for surfacing contextually relevant data into the workflow of a third party system are discussed herein. The system implements a near-real-time method of detecting activity corresponding to particular electronic health records associated with particular patients in third-party systems using specifically configured software systems. A cloud-based micro-services architecture is communicably coupled to the third-party systems and is operable to transmit contextually relevant data to the third-party system in response to particular detected activities, such as accessing a patient's electronic health record. The contextually-relevant data is identified by comparing electronic health record data from various third-party systems, each third-party system associated with the particular patient, to determine gaps in the records. The contextually relevant data is transmitted to the third-party system and visually integrated into the third-party system's pre-existing clinical workflow.

Abstract: Systems and methods for surfacing contextually relevant data into the workflow of a third party system are discussed herein. The system implements a near-real-time method of detecting activity corresponding to particular electronic health records associated with particular patients in third-party systems using specifically configured software systems. A cloud-based micro-services architecture is communicably coupled to the third-party systems and is operable to transmit contextually relevant data to the third-party system in response to particular detected activities, such as accessing a patient's electronic health record. The contextually-relevant data is identified by comparing electronic health record data from various third-party systems, each third-party system associated with the particular patient, to determine gaps in the records. The contextually relevant data is transmitted to the third-party system and visually integrated into the third-party system's pre-existing clinical workflow.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to high-voltage electrostatic discharge (ESD) devices and methods of manufacture. The structure includes a vertical silicon-controlled rectifier (SCR) connecting to an anode, and includes a buried layer of a first dopant type in electrical contact with an underlying buried layer a second dopant type split with an isolation region of the first dopant type within a substrate.

Abstract: A lifting apparatus for a case on a conveyor system. A chain vertically hangs over a conveyor belt. A hook is positioned on an end of the chain. A piston retracts and releases the chain. The hook interacts with and moves front flaps on cases traveling on the conveyor system.

Abstract: This disclosure describes, in part, a mobile apparatus for identifying items. For instance, the mobile apparatus may include a frame, a basket that attaches to the frame, a tray that attaches to the frame, and a user-facing module that attaches to the frame. Weight sensors may be located beneath the basket and the tray in order to determine the weights of items added to the mobile apparatus. The user-facing module may include imaging devices, such as cameras, that the mobile apparatus uses to perform one or more functions. For example, the mobile apparatus may use the imaging devices to identify items placed within the basket, determine locations of the mobile apparatus within a facility, and/or the like. By including these components, the mobile apparatus is able to generate data that represents the items added to the mobile apparatus, the weights of the items, and the costs of the items.

Abstract: A system for inspecting a wire segment includes an inspection apparatus and a visual imaging device. The apparatus includes an array of mirrors positioned about a centerline of the apparatus, wherein each mirror in the array is oriented such that a reflection of a first inspection zone of the wire segment in the array of mirrors forms a circumferential view of the first inspection zone of the wire segment, and the reflection from each mirror is within a field of view from a single vantage point. The visual imaging device is positioned at the single vantage point and oriented towards the wire segment such that the reflection from each mirror of the array of mirrors is within a field of view of the visual imaging device, the visual imaging device configured to capture at least one image of the reflection of the wire segment from the array of mirrors.

Abstract: Various embodiments of a system and method for capturing changes in trade information that impact trade authorization and for updating a chain state on a distributed chain database that is used to authorize trades are disclosed herein. In some embodiments, the system comprises: a trade controller configured to obtain a current state from a local database; a rules engine configured to be invoked by the trade controller to apply a ruleset to data extracted from the local database to generate an updated state; an operation auto detector configured to generate a plan to update a chain state on the distributed chain database based at least in part on the updated state; and an execution engine configured to execute the plan and to generate an updated chain state that is used to authorize trades.