Abstract: A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

Abstract: Information handling system (IHS) component immersion cooling systems and methods employ an apparatus having an IHS component immersion cooling flow passage housing disposed at (a) IHS component(s) of an IHS disposed in an immersion cooling tank. The IHS component immersion cooling flow passage housing has an immersion fluid inlet open to immersion fluid within tank and an immersion fluid outlet connected to a return line of an immersion fluid pump. The IHS component cooling apparatus flow passage housing may be a cold plate or a ducted heatsink disposed on, or about, the IHS component(s) of the IHS disposed in the immersion cooling tank. The immersion fluid pump may be the pump that also circulates the immersion fluid within the tank. The tank may include a manifold in fluid flow communication with the pump. This manifold may receive a plurality of return lines, each from an IHS component cooling apparatus.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Abstract: A system includes a first computing device client associated with a first user in a community of users operable to send content to publish to a data aggregation server. The data aggregation server is operable to receive the content to publish from the first computing device client, host a first user profile associated with the first user of the first computing device client, the first user profile identifying a targeted recipient in the community of users, and disseminate automatically the content received from the first computing device client to a second computing device client associated with the targeted recipient, without receiving input from the first computing device client explicitly specifying the targeted recipient to whom the content is disseminated.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: Systems and methods to fuse aviation-related data systems for comprehensive aircraft system health monitoring are provided. One example method includes obtaining, by one or more computing devices, fault data indicative of a plurality of fault indications provided by a first plurality of components of an aircraft. The method includes obtaining, by the one or more computing devices, condition indicators describing the respective operational conditions of a second plurality of components of the aircraft. The method includes fusing, by the one or more computing devices, the fault data with the condition indicators to form a comprehensive data set. The method includes identifying, by the one or more computing devices, one or more causes of the plurality of fault conditions based at least in part on the comprehensive data set. One example system includes a data fuser, a cause identifier, and an alert generator.

Abstract: A lighting control system for controlling a cumulative light emitted by a lighting fixture may comprise a light-emitting diode (LED) driver comprising an output for conducting an output current, and a control module electrically coupled to the output of the LED driver for receiving the output current. The LED driver may regulate the magnitude of the output current towards a target current, and may be characterized by a low-end intensity. The control module may be coupled to a first LED light source of the LED light sources. The control module may receive a command including a requested intensity and control the magnitude of a first LED current through the first LED light source. The control module may control the cumulative light output of the lighting fixture below the low-end intensity of the LED driver by diverting a portion of the output current away from the first LED light source.

Abstract: A method of accumulating a personalized list of products viewed by a user on different website domains includes providing a first embedded code on a first website domain and a second embedded code on a second website domain in which the first website domain is different from said second website domain. Each of the embedded codes allows a specified third party server to communicate interactively with the user. The method further includes automatically accumulating a personalized list of products viewed by the user in a database on the specified third party server, wherein the personalized list includes at least a first product and a second product, wherein the first product is on the first website domain and the second product is on the second website domain.

Abstract: Systems and methods for authenticating access to multiple data stores substantially in real-time are disclosed. The system may include a server coupled to a network, a client device in communication with the server via the network and a plurality of data stores. The server may authenticate access to the data stores and forward information from those stores to the client device. An exemplary authentication method may include receipt of a request for access to data. Information concerning access to that data is stored and associated with an identifier assigned to a client device. If the identifier is found to correspond to the stored information during a future request for access to the store, access to that store is granted.

Abstract: The present invention relates to a (bio)pharmaceutical composition, particularly a liquid (e.g. aqueous) biopharmaceutical composition, more particularly a liquid biopharmaceutical composition comprising an anti-EGFR/anti-LGR5 bispecific antibody. The present invention also relates inter alia to a method of manufacturing the composition, to a kit including the composition, to a package including the composition, to a method of manufacturing the package, and to methods of treatment using the composition and/or package, especially cancer treatments, for example, for the treatment of colorectal cancer.

Abstract: A method and apparatus of making an aerosol container. A polymeric container may be provided. The container may have a closed end bottom and a neck longitudinally opposed to the closed end bottom. The container has an internal container volume. A valve and a bag may be provided and a portion of the valve and the bag may be disposed within the container. The bag has a first bag volume. A portion of the at least one of the neck and the bag may contact a portion of the valve to form a temporary seal. Propellant may be introduced into the container. The bag may be collapsed from the first bag volume to a second bag volume. The pressure of the propellant and the pressure within the bag equilibrate. The valve may be joined to the container and the propellant may be sealed within the container.

Abstract: A system includes a first computing device client associated with a first user in a community of users operable to send content to publish to a data aggregation server. The data aggregation server is operable to receive the content to publish from the first computing device client, host a first user profile associated with the first user of the first computing device client, the first user profile identifying a targeted recipient in the community of users, and disseminate automatically the content received from the first computing device client to a second computing device client associated with the targeted recipient, without receiving input from the first computing device client explicitly specifying the targeted recipient to whom the content is disseminated.

Abstract: Systems and methods for adjusting yield values for crops based on scan data associated with the crops are provided. One example computer-implemented method includes initially classifying data points of a composite data set into one of a ground class and a vegetation class. The method also includes determining a canopy height model (CHM) for the plot based on the classified composite data set, where the CHM includes at least one of the data points classified in the vegetation class, and computing a plant height for the plot based on the CHM. The method further includes determining a neighboring plant height difference based on the plant height for the plot and a plant height for each of at least one neighboring plot to said plot, computing a yield adjustment based on the determined neighboring plant height difference(s), and determining a plot yield for the plot, based on the yield adjustment.

Abstract: The present disclosure describes methods, devices and systems comprising materials comprising dielectrics. In various aspects, electrodes layered or imbedded with these dielectrics provide enhanced properties for a wide range of applications, such as the enhanced separation of analytes, such as biological molecules or particles (nucleic acids, viruses) with an electrokinetic field.

Abstract: In an example implementation according to aspects of the present disclosure, a head mounted display (HMD) system which comprises an HMD positioned on an upper portion of a face of a wearer. The HMD system further comprises a facial gesture mask coupled to the HMD and positioned on a lower portion of the face of the wearer and comprising at least one light source and at least one camera to capture image data of the wearer. The HMD system also includes a processor to process the captured image data of the wearer to identify a gesture of the wearer.

Abstract: A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

Abstract: Files can be located using a durable and universal file identifier. A content URI includes a file protocol URI specifying a path to a file. The file protocol URI includes a query string specifying properties of the file that can be utilized to locate the file, such as an object ID property specifying a GUID for the file and a volume ID property specifying a GUID for a storage volume storing the file. The content URI can be utilized to locate the file using the file protocol URI and its associated query string even if the file has been moved, renamed, or is accessed on a different computing device. Operations can then be performed using the file, such as resuming a previously performed activity that used the file.

Abstract: A system includes a first computing device client associated with a first user in a community of users operable to send content to publish to a data aggregation server. The data aggregation server is operable to receive the content to publish from the first computing device client, host a first user profile associated with the first user of the first computing device client, the first user profile identifying a targeted recipient in the community of users, and disseminate automatically the content received from the first computing device client to a second computing device client associated with the targeted recipient, without receiving input from the first computing device client explicitly specifying the targeted recipient to whom the content is disseminated.