Abstract: An ophthalmic lens assembly comprising an electronic system with a controller configured to implement a blink detection algorithm is described herein. The electronic system can also include one or more power sources, circuitry, one or more sensors, clock generation circuitry, control algorithms, and lens driver circuitry. The algorithm can be used to sample, at a predetermined rate, light incident on an eye of an individual and at least temporarily save collected samples, determine when an eyelid is open or closed, determine a time period and pulse width of the blinks from the collected samples, calculate a number of blinks and the duration of the blinks in a given time period, and compare the number of blinks, the durations of the blinks in the given time period, and the time between blinks in the given time period to a stored set of samples to determine blinking patterns.

Abstract: A lens driver or lens driver circuitry for an ophthalmic apparatus comprising an electronic system which actuates a variable-focus optic is disclosed herein. The lens driver is part of an electronic system incorporated into the ophthalmic apparatus. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The lens driver circuitry includes one or more power sources, one or more high voltage generators and one or more switching circuits.

Abstract: A wake circuit is designed to minimize leakage current from a battery or other suitable energy source connected to various electronic components. The wake circuit essentially connects/disconnects or couples/decouples the battery or other power source from the other components when the device is in a storage state or otherwise idle.

Abstract: Disclosed is an antigen presentation enhancing hybrid polypeptide which includes three elements. The first element is an N-terminal element consisting essentially of 4-16 residues of the mammalian li-Key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and non-N-terminal deletion modifications thereof that retain antigen presentation enhancing activity. The second element is a chemical structure covalently linking the N-terminal element described above to the MHC Class II-presented epitope described below. The chemical structure is a covalently joined group of atoms which when arranged in a linear fashion forms a flexible chain which extends up to the length of 20 amino acids likewise arranged in a linear fashion, the chemical structure being selected from the group consisting of: i) immunologically neutral chemical structures, ii) a MHC Class I epitope or a portion thereof, and/or iii) an antibody-recognized determinant or a portion thereof.

Abstract: A pavement marking tape has raised, irregular polygonal relief features with retroreflective elements covering a portion of the surface of the tape. The form of the relief features minimizes shadowing effects. Raised relief features are shaped to increase the visible number of vertical faces and edges of the relief features, which are the most reflective structures, and are oriented toward incident light from an approaching observer to maximize retroreflectivity.

Abstract: A blink detection algorithm and associated circuitry for an ophthalmic lens comprising an electronic system is described herein. The blink detection algorithm is implemented in the system controller which is part of an electronic system incorporated into the ophthalmic lens. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry.

Abstract: Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK (SEQ ID NO: 2) residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide.

Abstract: An ophthalmic lens assembly comprising an electronic system with a controller configured to implement a blink detection algorithm is described herein. The electronic system can also include one or more power sources, circuitry, one or more sensors, clock generation circuitry, control algorithms, and lens driver circuitry. The algorithm can be used to sample, at a predetermined rate, light incident on an eye of an individual and at least temporarily save collected samples, determine when an eyelid is open or closed, determine a time period and pulse width of the blinks from the collected samples, calculate a number of blinks and the duration of the blinks in a given time period, and compare the number of blinks, the durations of the blinks in the given time period, and the time between blinks in the given time period to a stored set of samples to determine blinking patterns.

Abstract: Antennas and antenna systems may be designed and configured for incorporation into mechanical devices, including medical devices, such as ophthalmic devices, including contact lenses. These antennas and antenna systems may be utilized to transmit data from the mechanical device to a receiver, to receive data from a transmitter, and/or to inductively charge an electromechanical cell or the like incorporated into the mechanical device.

Abstract: An athlete recruiting network in which athletes create athlete profiles that are stored within an athlete module of a recruiting database. One or more coaches use coach interfaces to create coaching rosters that are stored within a coach module within the recruiting database. The athlete interfaces and the coach interfaces include computers, laptops, telephones and other forms of remote terminals that are wired or wirelessly connected to the database. The athlete recruiting network allows coaches to search for one or more athletes based on desired characteristics such as athletic statistics, the athlete's position or particular skills, the athlete's academic achievements, and other criteria designated by the coach. Further, the athlete-recruiting network allows the athletes to promote their particular skills or abilities to coaches searching for athletes to complete the coach's roster.

Abstract: Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope, or said encoded protein or peptide. In addition, the nucleic acid molecule comprises a second expressible nucleic acid sequence encoding an antigen presentation enhancing hybrid polypeptide, or said encoded protein or peptide.

Abstract: A wireless protocol for a communication system is set forth herein which may be utilized for communication between a transmitter and a receiver over any type of communication channel. The wireless communication protocol provides for the reduction of receiver active or on time which in turn lowers power consumption. The wireless communication protocol enables the complexity and receiver size to be reduced. The methodology employed in the protocol utilizes a unique message frame in conjunction with repeated transmission and periodic receiver searching.

Abstract: A wireless protocol for a communication system is set forth herein which may be utilized for communication between a transmitter and a receiver over any type of communication channel. The wireless communication protocol provides for the reduction of receiver active or on time which in turn lowers power consumption. The wireless communication protocol enables the complexity and receiver size to be reduced. The methodology employed in the protocol utilizes a unique message frame in conjunction with repeated transmission and periodic receiver searching.

Abstract: A blink detection algorithm and associated circuitry for an ophthalmic lens comprising an electronic system is described herein. The blink detection algorithm is implemented in the system controller which is part of an electronic system incorporated into the ophthalmic lens. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry.

Abstract: A system controller for an ophthalmic lens comprising an electronic system which actuates a variable-focus optic is disclosed herein. The system controller is part of an electronic system incorporated into the ophthalmic lens. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The controller including multiple state machines configured as digital logic gates.

Abstract: A lens driver or lens driver circuitry for an ophthalmic apparatus comprising an electronic system which actuates a variable-focus optic is disclosed herein. The lens driver is part of an electronic system incorporated into the ophthalmic apparatus. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The lens driver circuitry includes one or more power sources, one or more high voltage generators and one or more switching circuits.

Abstract: Antennas and antenna systems may be designed and configured for incorporation into mechanical devices, including medical devices, such as ophthalmic devices, including contact lenses. These antennas and antenna systems may be utilized to transmit data from the mechanical device to a receiver, to receive data from a transmitter, and/or to inductively charge an electromechanical cell or the like incorporated into the mechanical device.

Abstract: A method, apparatus and computer program product for providing extensible code visualization are presented. Program code is received. A model is generated relating to the program code. The model is mapped to a user interface (UI) to produce a UI reflecting the program code. Changes made to the program code are reflected in the UI and changes made to the UI are reflected in the program code via the model.

Abstract: The present invention is a phase dithered digital communications system that includes a digital receiver, and uses phase dithering to spread the energy of one or more system clocks to minimize receiver de-sensitization. Phase dithering uses a single frequency for each system clock; however, the energy of each system clock is spread over a range of frequencies by changing the duty-cycle of each clock half-cycle. A non-phase dithered clock drives the sampling clock of a receiver analog-to-digital converter to provide accurate correlation with received information, which may allow use of a higher frequency sampling clock than in frequency dithered designs. Phase dithered clocks and non-phase dithered clocks may have constant frequencies that are related to each other by a ratio of two integers; therefore, the time base used for extracting received data is always correlated and accurate.

Abstract: The present invention is a frequency and phase locked loop (FPLL) synthesizer having a frequency-locked loop (FLL) operating mode and a phase-locked loop (PLL) operating mode. The FLL operating mode is used for rapid coarse tuning of the FPLL synthesizer and is followed by the PLL operating mode for fine tuning and stabilization of the frequency of an output signal from the FPLL synthesizer. The FPLL synthesizer includes a variable frequency oscillator, which is controlled by FLL circuitry during the FLL operating mode or by PLL circuitry during the PLL operating mode. The FLL circuitry includes frequency division circuitry for reducing the frequency of the output signal, frequency detection circuitry for measuring the frequency error of the frequency reduced output signal, and a loop filter to control the bandwidth of an FLL control loop formed by the FLL circuitry and the variable frequency oscillator.