Patents by Inventor Robert M. Moriarty

Robert M. Moriarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biopsy methods and devices
    Patent number: 11480577
    Abstract: Disclosed are methods for detecting remnant cancer cells in a tissue sample.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: October 25, 2022
    Assignee: INDICATOR SYSTEMS INTERNATIONAL, INC.
    Inventors: Gerald F. Swiss, John V. Fante, Robert M. Moriarty, Richard J. Pariza
  • USE OF 1-ALPHA-HYDROXYVITAMIN D5 AND RELATED COMPOUNDS AS PROPHYLACTIC OR THERAPEUTIC AGENTS FOR SARS-COV-2 (COVID-19 VIRUS) AND RELATED INFECTIONS
    Publication number: 20220054510
    Abstract: The use of 1-alpha-hydroxyvitamin D5 or related compounds as prophylactic or therapeutic agents for SARS-CoV-2 (Covid-19 virus) and related infections. The compounds may be administered orally, by inhalation, nasal spray, eye drops, or by injection. The compounds may be administered to persons who are unwilling, unable or adverse to be vaccinated. The compounds also may be administered to immunocompromised persons for whom vaccination may not provide adequate protection from infection.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 24, 2022
    Inventors: Richard J. Pariza, Robert M. Moriarty
  • Synthetic bile acid compositions and methods
    Patent number: 11202786
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: December 21, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • NORIBOGAINE COMPOSITIONS
    Publication number: 20210275538
    Abstract: Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.
    Type: Application
    Filed: March 16, 2021
    Publication date: September 9, 2021
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
    Publication number: 20210252021
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Application
    Filed: February 17, 2021
    Publication date: August 19, 2021
    Applicant: ALLERGAN SALES, LLC
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • Synthetic bile acid compositions and methods
    Patent number: 11026955
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: June 8, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Preparation of bile acids and intermediates thereof
    Patent number: 11008363
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 18, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Methods for the purification of deoxycholic acid
    Patent number: 10981946
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: April 20, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • Formulations of deoxycholic acid and salts thereof
    Patent number: 10946030
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 16, 2021
    Assignee: Allergan Sales, LLC
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • Compositions and methods for detecting cancer cells in a tissue sample
    Patent number: 10890588
    Abstract: This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 12, 2021
    Assignee: ISI Life Sciences, Inc.
    Inventors: John Fante, Theodore Hessler, III, Robert M. Moriarty, Richard Pariza, Gerald F. Swiss, David White, Craig Keshishian
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20200317716
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 8, 2020
    Applicant: ALLERGAN SALES, LLC
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Methods to detect remnant cancer cells
    Patent number: 10753942
    Abstract: Disclosed methods for detecting remnant cancer cells in a tissue sample.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: August 25, 2020
    Assignee: Indicator Systems International, Inc.
    Inventors: Robert M. Moriarty, Richard J. Pariza, David M. White, Gerald F. Swiss
  • BIOPSY METHODS AND DEVICES
    Publication number: 20200150127
    Abstract: Disclosed are methods for detecting remnant cancer cells in a tissue sample.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Inventors: Gerald F. Swiss, John V. Fante, Robert M. Moriarty, Richard J. Pariza
  • Preparation of bile acids and intermediates thereof
    Patent number: 10633412
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: April 28, 2020
    Assignee: Allergan Sales, LLC
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID
    Publication number: 20200095274
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Application
    Filed: October 2, 2019
    Publication date: March 26, 2020
    Applicant: ALLERGAN SALES, LLC
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20200085843
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: September 25, 2019
    Publication date: March 19, 2020
    Applicant: ALLERGAN SALES, LLC
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20200078373
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 12, 2020
    Applicant: ALLERGAN SALES, LLC
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Biopsy methods and devices
    Patent number: 10539567
    Abstract: Disclosed are methods for detecting remnant cancer cells in a tissue sample.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: January 21, 2020
    Assignee: Indicator Systems International, Inc.
    Inventors: Gerald F. Swiss, John V. Fante, Robert M. Moriarty, Richard J. Pariza
  • Methods for the purification of deoxycholic acid
    Patent number: 10472384
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: November 12, 2019
    Assignee: ALLERGAN SALES, LLC
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • Synthetic bile acid compositions and methods
    Patent number: 10434107
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 8, 2019
    Assignee: ALLERGAN SALES, LLC
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood