Patents by Inventor Robert M. Moriarty

Robert M. Moriarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective total synthesis of noribogaine
    Patent number: 8937061
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: January 20, 2015
    Assignee: DemeRx, Inc.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • STEREOSELECTIVE TOTAL SYNTHESIS OF NORIBOGAINE
    Publication number: 20150005492
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Applicant: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Synthetic bile acid compositions and methods
    Patent number: 8883770
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: November 11, 2014
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Synthetic voacangine
    Patent number: 8877921
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: November 4, 2014
    Assignee: DemeRx, Inc.
    Inventor: Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 8859764
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: October 14, 2014
    Assignee: DemeRx, Inc.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, Jr.
  • Sulfate esters of noribogaine
    Patent number: 8853201
    Abstract: Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: October 7, 2014
    Assignee: DemeRx, Inc.
    Inventors: Richard D. Gless, Jr., Robert M. Moriarty
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20140179684
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: January 2, 2013
    Publication date: June 26, 2014
    Applicant: DemeRx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, JR., Robert M. Moriarty
  • SUBSTITUTED NORIBOGAINE
    Publication number: 20140179685
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Application
    Filed: January 29, 2013
    Publication date: June 26, 2014
    Inventors: Deborah C. Mash, Richard D. Gless, JR., Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 8742096
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: June 3, 2014
    Assignee: DemeRx, Inc.
    Inventors: Robert M. Moriarty, Simon Mbua Ngale Efange
  • FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
    Publication number: 20140148429
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 29, 2014
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
    Patent number: 8653058
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: February 18, 2014
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20140038932
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: June 10, 2013
    Publication date: February 6, 2014
    Applicant: KYTHERA BIOPHARMACEUTICALS, INC.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
    Patent number: 8637648
    Abstract: This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: January 28, 2014
    Assignee: Demerx, Inc.
    Inventors: Deborah C. Mash, Robert M. Moriarty
  • METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE
    Publication number: 20130303756
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: January 23, 2012
    Publication date: November 14, 2013
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, JR.
  • (1R,4R) 7-OXO-2-AZABICYCLO[2.2.2]OCT-5-ENE AND DERIVATIVES THEREOF
    Publication number: 20130267710
    Abstract: This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms, intermediates thereto, and processes of their synthesis.
    Type: Application
    Filed: January 24, 2013
    Publication date: October 10, 2013
    Inventor: Robert M. Moriarty
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20130267721
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: January 28, 2013
    Publication date: October 10, 2013
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • METHODS FOR PREPARING SYNTHETIC BILE ACIDS AND COMPOSITIONS COMPRISING THE SAME
    Publication number: 20130261317
    Abstract: This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation.
    Type: Application
    Filed: September 19, 2011
    Publication date: October 3, 2013
    Applicant: KYTHERA BIOPHARMACEUTICALS, INC.
    Inventors: Robert M. Moriarty, Photon Rao
  • Synthetic bile acid compositions and methods
    Patent number: 8546367
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: October 1, 2013
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20130252931
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: August 12, 2010
    Publication date: September 26, 2013
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Synthetic bile acid compositions and methods
    Patent number: 8461140
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: June 11, 2013
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood