Patents by Inventor Robert M. Moriarty

Robert M. Moriarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
    Publication number: 20180015105
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Application
    Filed: July 28, 2017
    Publication date: January 18, 2018
    Applicant: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20170342101
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: June 8, 2017
    Publication date: November 30, 2017
    Applicant: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID
    Publication number: 20170320905
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 9, 2017
    Applicant: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • Substituted noribogaine
    Patent number: 9783535
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 10, 2017
    Inventors: Deborah C. Mash, Richard D. Gless, Robert M. Moriarty
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20170258814
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: March 28, 2017
    Publication date: September 14, 2017
    Applicant: KYTHERA BIOPHARMACEUTICALS, INC.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Formulations of deoxycholic acid and salts thereof
    Patent number: 9737549
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: August 22, 2017
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • COMPOSITIONS FOR DETECTING CANCER CELLS ON A CELLULAR SURFACE
    Publication number: 20170234878
    Abstract: Disclosed are compositions and methods for assessing the presence of tumor cells amongst normal cells.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 17, 2017
    Applicant: ISI Life Sciences, Inc.
    Inventors: Gerald F. Swiss, Robert M. Moriarty
  • Synthetic bile acid compositions and methods
    Patent number: 9683008
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: June 20, 2017
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Methods for the purification of deoxycholic acid
    Patent number: 9683007
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxysteroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This inversion is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 20, 2017
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, Jr.
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20170136040
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: November 11, 2016
    Publication date: May 18, 2017
    Applicant: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • MICROBIAL GROWTH INDICATING MEDICAL DEVICES
    Publication number: 20170128595
    Abstract: Provided herein are medical devices capable of self-reporting microbial growth adjacent the site of the implanted device.
    Type: Application
    Filed: June 22, 2015
    Publication date: May 11, 2017
    Applicant: Indicator Systems International, Inc.
    Inventors: Gerald F. Swiss, Robert M. Moriarty, Ram W. Sabnis
  • Synthetic bile acid compositions and methods
    Patent number: 9636349
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: May 2, 2017
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Synthetic noribogaine
    Patent number: 9617274
    Abstract: Synthetic noribogaine preferably free of ibogaine and, optionally, one or more of other naturally occurring Tabernanth iboga alkaloids, is provided.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: April 11, 2017
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Richard D. Gless, Jr.
  • Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
    Patent number: 9550789
    Abstract: Provided herein are halogenated indole and benzofuran derivatives of isoquinuclidene and intermediates thereto, and processes, preferably enantioselective processes, for preparing such derivatives including processes for preparing (?) and (+) noribogaine, in substantially enantiomerically pure forms.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: January 24, 2017
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Mark Kinch
  • Synthetic bile acid compositions and methods
    Patent number: 9522155
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: December 20, 2016
    Assignee: KYTHERA BIOPHARMACEUTICALS, INC.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • SYNTHETIC VOACANGINE
    Publication number: 20160311823
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Applicant: DemeRx, Inc.
    Inventor: Robert M. Moriarty
  • Synthetic voacangine
    Patent number: 9469649
    Abstract: Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: October 18, 2016
    Assignee: DEMERX, INC.
    Inventor: Robert M. Moriarty
  • Methods and compositions for preparing noribogaine from voacangine
    Patent number: 9403817
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 2, 2016
    Assignee: DEMERX, INC.
    Inventors: Deborah C. Mash, Robert M. Moriarty, Richard D. Gless, Jr.
  • Stereoselective total synthesis of noribogaine
    Patent number: 9403837
    Abstract: This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: August 2, 2016
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Noribogaine compositions
    Patent number: 9358237
    Abstract: Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: June 7, 2016
    Assignee: DEMERX, INC.
    Inventors: Robert M. Moriarty, Deborah C. Mash