Patents by Inventor Robert M. Moriarty

Robert M. Moriarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID
    Publication number: 20130137884
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-?-hydroxy-steroids from ?-9,11-ene, 11-keto or 11-hydroxy-?-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.
    Type: Application
    Filed: December 17, 2010
    Publication date: May 30, 2013
    Inventors: Robert M. Moriarty, Achampeta Rathan Prasad, John Gregory Reid, Roy A. Swaringen, JR.
  • NORIBOGAINE COMPOSITIONS
    Publication number: 20130131046
    Abstract: Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.
    Type: Application
    Filed: July 22, 2011
    Publication date: May 23, 2013
    Inventors: Robert M. Moriarty, Deborah C. Mash
  • Combinatorial library approach to iminocyclitols with biological activity
    Patent number: 8445670
    Abstract: A method of synthesizing stereochemically defined iminocyclitol comprises replacing an intraring oxygen in a cyclic sugar by an intraring imine to form an iminocyclitol, wherein said iminocyclitol has a defined stereochemical configuration different from a stereochemical configuration of the cyclic sugar. The invention also provides combinatorial libraries of iminocyclitol compounds, allowing for diverse C1 and N-substitution. In addition, provided are methods of treating viral infections with iminocyclitols compounds.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: May 21, 2013
    Assignee: United Therapeutics Corporation
    Inventors: Robert M. Moriarty, Carmen Mitan, Kenneth R. Phares
  • INFECTION ACTIVATED WOUND CARING COMPOSITIONS AND DEVICES
    Publication number: 20130064772
    Abstract: Provided are wound caring compositions and devices containing a pH-sensitive, preferably acid degradable, components contained in a water-permeable and hydronium ion permeable material. The pH-sensitive component encloses an antibiotic which is released to the wound upon infection by a microorganism at the wound site, and/or encloses a pH indicator. The antibiotic release is triggered by the microorganism's production of CO2 at the wound site which forms carbonic acid, lowers the pH at the pH sensitive components, and thus results in rupture of the liposome.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 14, 2013
    Inventors: Gerald F. Swiss, Stefan Schwabe, Robert M. Moriarty
  • Preparation of bile acids and intermediates thereof
    Patent number: 8367852
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: February 5, 2013
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20130029958
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: June 1, 2012
    Publication date: January 31, 2013
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Substituted noribogaine
    Patent number: 8362007
    Abstract: This invention relates noribogaine derivatives, compositions and methods of use thereof.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: January 29, 2013
    Assignee: Demerx, Inc.
    Inventors: Deborah C. Mash, Richard D. Gless, Jr., Robert M. Moriarty
  • Preparation of bile acids and intermediates thereof
    Patent number: 8362285
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: January 29, 2013
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20120302525
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: June 1, 2012
    Publication date: November 29, 2012
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
    Publication number: 20120258943
    Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.
    Type: Application
    Filed: August 10, 2011
    Publication date: October 11, 2012
    Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
  • METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE
    Publication number: 20120253037
    Abstract: Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
    Type: Application
    Filed: March 14, 2012
    Publication date: October 4, 2012
    Inventors: Robert M. Moriarty, Simon Mbua Ngale Efange
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20120238537
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: June 1, 2012
    Publication date: September 20, 2012
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Synthetic bile acid compositions and methods
    Patent number: 8242294
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: August 14, 2012
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • Iminosugar compounds with antiflavirus activity
    Patent number: 8097728
    Abstract: An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, R6 is at least one of alkyl or branched alkyl, heteroalkyl or aryl, R6? is a bridging group selected from at least one of bicycle[2.2.1]heptyl, bicycle[3.2.1]octyl, oxa analogs, admonyl and cubyl, n?=2-10, n?=1-10, enantiomers and stereoisomers of said compounds and physiologically acceptable salts or solvates of said compounds, enantiomer or stereoisomer.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: January 17, 2012
    Assignees: Philadelphia Health & Education Corporation, The Board Of Trustees Of The University of Illinois
    Inventors: Baohua Gu, Timothy M. Block, Robert M. Moriarty, Mahendra N. Deshpande, Rajendra C. Shah
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20110224448
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: May 25, 2011
    Publication date: September 15, 2011
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Preparation of bile acids and intermediates thereof
    Patent number: 7994351
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: August 9, 2011
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20110152552
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: January 20, 2011
    Publication date: June 23, 2011
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • Preparation of bile acids and intermediates thereof
    Patent number: 7902387
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: March 8, 2011
    Assignee: Kythera Biopharmaceuticals, Inc.
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
  • SYNTHETIC BILE ACID COMPOSITIONS AND METHODS
    Publication number: 20100160276
    Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
    Type: Application
    Filed: August 13, 2009
    Publication date: June 24, 2010
    Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
  • PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
    Publication number: 20100145083
    Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
    Type: Application
    Filed: November 6, 2009
    Publication date: June 10, 2010
    Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, JR., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo