Abstract: The present invention provides compounds that inhibit cyclin kinase inhibitor p21, such as compounds of formula I. The present invention also provides compositions including compounds of Formula I and a pharmaceutically acceptable excipient. In addition, the present invention provides methods of inhibiting cyclin kinase inhibitor p21 and of treating cancer.

Abstract: A vehicle includes a power inverter module (PIM), a motor/generator unit (MGU), vehicle components, temperature sensors, and a controller. The sensors measure temperatures of a motor winding of the MGU, and temperatures of the multiple phase outputs of the PIM. The second plurality of temperature sensors measures temperatures of the vehicle components. The controller calculates an average temperature of the components, and individually diagnoses each temperature sensor using the average temperature. A control circuit for the vehicle includes the first and second plurality of sensors and the controller. A temperature performance diagnostic method includes using the first plurality to measure a temperature of the motor winding and the phase outputs of the PIM, using the second plurality to measure a temperature of the components, calculating an average temperature of the components, and individually diagnosing the performance of each of the first plurality of sensors using the average temperature.

Abstract: A health monitoring system includes a client device having one or more sensors to take medical or environmental measurements. The client device can interact with a server device to guide the user through the use of a sensor. The state of the sensors is controlled at the server to provide for flexibility of the health monitoring system.

Abstract: Improved systems and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.

Abstract: The present invention relates generally to methods of preventing or treating toxicities of the skin, hair, and/or nails, which are associated with administration of one or more multikinase inhibitors, with light-emitting diode photomodulation treatment, either alone or in combination with other agents.

Abstract: The present invention relates generally to methods of preventing or treating toxicities of the skin, hair, and/or nails, which are associated with administration of one or more epidermal growth factor receptor inhibitors, with light-emitting diode photomodulation treatment, either alone or in combination with other agents.

Abstract: The present invention relates generally to methods of preventing or treating toxicities of the skin, hair, and/or nails, which are associated with administration of one or more vascular endothelial growth factor receptor inhibitors, with light-emitting diode photomodulation treatment, either alone or in combination with other agents.

Abstract: Polymer-clay nanocomposites and methods of making the same are provided. In an embodiment, a polymer-clay nanocomposite comprises a non-metal salt of an ionomer and a nanostructured layered clay. An example of the ionomer is a tetra-octyl ammonium salt of sulfonated polystyrene, and an example of the clay is sodium-montmorillonite.

Abstract: The invention relates to a method and device for printing a substrate. The printable substrate is moved through at least one printing mechanism in order to print a static or non-variable printing image. According to the invention, the printable substrate is moved through at least one printing device, which is coupled in-line to the printing mechanism to individualize the static pattern with at least one dynamic or variable printing image.

Abstract: Improved devices and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.

Abstract: A card-type memorabilia article including a photographic print paper intermediate layer, a urethane top layer, and an ink-receptive laminate. The intermediate layer defines opposing, first and second major surfaces, and displays a photographic image on the first major surface. The urethane top layer is applied over the first major surface. The ink-receptive laminate is applied over the second major surface, with the laminate defining an outer face. The ink-receptive coating protects ink that is written onto the outer face from smudging and smearing. The high quality photographic image is environmentally protected by the urethane layer, whereas the laminate not only protects against water damage, but also receives autographs or other ink-created marking without smudging or smearing.

Abstract: Helical tube evaporators are used to concentrate aqueous extract solutions from the extraction of polyamides based on polyamide 6. A process for preparing polyamides based on polyamide 6 comprises the stages of b) monophasic or biphasic reaction of aqueous extract solutions from the extraction of polyamides based on polyamide 6, which may be enriched with caprolactam, aminocapronitrile, aminocaproic acid or mixtures thereof, in a prereactor at pressures in the range from 5 to 40 bar and temperatures in the range from 150 to 300° C., the gaseous phase formed being removable from the liquid phase in the case of the biphasic reaction, c) discharge of the reaction mixture from stage b) through a helical tube evaporator at a temperature in the range from 220 to 300° C. with pressure reduction to about atmospheric pressure and removal of a gaseous phase to obtain a liquid phase, d) further reaction of the liquid phase from stage c) at temperatures in the range from 240 to 300° C.

Abstract: A method is provided for cold forming center web or webless tapered piston pins in one forming sequence. The method eliminates secondary operations such as but not limited to machining, annealing, coating and secondary forming. The method includes the steps of cutting a metal rod into a substantially cylindrical slug piece, die extruding the slug piece to form a first cavity in the slug piece, optionally die extruding the slug piece to form a second cavity in the slug piece, piercing the slug piece to form the slug piece into a hollow cylindrical piece, die extruding the hollow cylindrical piece at either end to form a hollow cylindrical piece having a taper on an internal surface of the hollow cylindrical piece at either end.

Abstract: The aim of the invention is to simplify the attachment of RFID chips or RFID transponders to packagings. For this purpose, the RFID chips are produced as a single RFID label together with antenna elements that are functionally associated therewith. The chips or transponders can be attached to a packaging by means of corresponding devices during production of the printed material, during a subsequent treatment or finishing process of the printed material, during the preparation of the packaging, during production of the packaging or during filling of the packaging. At the time of attachment, the RFID chips can be tested and initialized. The invention allows to considerably simplify the so far complex processes required to integrate the RFID chips into different types of packaging.

Abstract: The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing.

Abstract: A method for producing a printed product, wherein at least one printing substrate webs are transported through at least one printing form-based printing unit for static printing of at least one printing substrate webs with a printed image which remains unchanged for printed copies of the printed product. In addition, at least one of the statically printed printing substrate webs is printed inline dynamically with the static printing in a region of at least one printing device of the web press without a printing form with access data, e.g., a prize code, which is individualized for at least some printed copies. Here, information content, such as a prize, which extends beyond the printed product can be accessed by the access data for a purchaser of the printed product over an interactive medium, such as the Internet. Access data specific to a target person and/or a target group are printed in the printed copies as individual access data.

Abstract: A method for producing a printed product on a web press, wherein a plurality of printing substrate webs which are to be printed are held ready at a plurality of reel splicers of the web press. The plurality of printing substrate webs are transported respectively through at least one printing form-based printing unit of the web press for the static printing of an image on the plurality of printing substrate webs which does not change for printed copies of the printed product.

Abstract: Semiconductor wafers are processed so as to remove material on one or both sides by means of at least one grinding tool, with coolant supplied into a contact region between the semiconductor wafer and the at least one grinding tool, characterized in that the coolant flow rate is set as a function of a grinding tooth height of the at least one grinding tool and this coolant flow rate is reduced as the grinding tooth height decreases.

Abstract: This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 1.8 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308. A motorized pull-back device 104 is used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

Abstract: There is a variety of media that may be inserted into a reading or writing device, such as CD's, USB drives, floppy disks, memory sticks, and many other devices. Media is inserted into a media reading or writing device that is in communication with a computer or network device. Upon insertion of the media, a number of metadata regarding that media is available to the computer. The trustworthy calculator is typically a plug-in software module that processes each piece of volume metadata and applies a weighed score, resulting in a Trustworthy Factor. A scoring matrix denotes ranges of values of the Trustworthy Factor into a Level of Trust Zone. Based on the Level of Trust Zone, appropriate action handlers may direct the computer to disallow the mounting of the media, may require specific authentication action to take place prior to allowing a mount of the media, or may indicate that the media may be mounted without further authentication.