Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: The present specification discloses compositions comprising one or more monoterpene compounds and HA polymers as well as methods and uses of such compositions for treating a soft tissue condition of an individual and/or cellular senescence in a skin region of an individual.

Abstract: A framework for developing a customized therapeutic or cosmetic formulation, and application thereof, that is a specific to an individual, and to the skin condition individual suffers from, for treatment thereof. This framework incorporates input data that together represents clinical data, genomic data, and ingredient data, and applies this information to a neural network to improve simulations of treatments by associating variables extracted from relevant data points relative to the patient and skin condition, and integrating comparisons with both in vivo measurements and conditions experienced by and treated for in similar patients over time. This application of artificial intelligence may be utilized in any medical setting, is not limited to treating dermatological or skin-related ailments.

Abstract: Employing methodologies and systems to detect damage initiation and growth inside a composite material (matrix cracking, delamination, fiber break, fiber pullout, etc.) wherein damage produces high-frequency acoustic emission (AE) waves that are transported to recording sensors along with relatively lower frequency waves representing the flexural deformation of the impacted composite structure.

Abstract: A computer implemented method of determining a fact matching a user requirement, comprising the steps of providing an ontology and a semantic database, and controlling a computer processor to perform the steps of accepting a query defining a template for a statement regarding a fact, identifying matching patterns in the semantic database, and outputting either a matching statement or information supporting the user to locate corresponding information, characterised in that a formula is provided defining a maximum semantic distance that a class or instance may be broadened to, and in identifying patterns, for each instance/class having a non-zero divergence value, one or more broader classes is accordingly treated as a match. This enables the user to identify facts that would otherwise be difficult to identify, and enables the user to identify relevant facts of a type or category which the user might not have thought to look specifically for.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: Detection, identification, and monitoring of various composite-damage types such as impact damage, delaminations, etc. using angle-beam coupled guided waves and methods and systems that permit excitation with angle-beam techniques of certain composite-material guided-wave modes that cannot be excited in isotropic metals with angle-beam methods.

Abstract: An electrically operable clipper has a body portion and a head portion, wherein the head portion includes a movable cutter and a fixed comb. The clipper includes an internally located electric motor operable to move the movable cutter. The clipper further includes an operating switch movable between an off position, an operating position and a reset position, wherein the reset position operates a motor reset module of the clipper.

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.

Abstract: A method may include receiving a domain name system (DNS) query at a network device, where the DNS query may be associated with a traffic flow identified for rerouting through an alternative path utilizing an alternative network device instead of a default path. The method may also include rewriting the DNS query such that the DNS query is routed through the alternative network device along the alternative path and to a DNS server associated with the alternative path. The method may additionally include receiving a DNS response from the DNS server, where a resource identified in the DNS response may be based on the DNS query coming through the alternative network device.

Abstract: A method may include receiving a domain name system (DNS) query at a network device, where the DNS query may be associated with a traffic flow identified for rerouting through an alternative path utilizing an alternative network device instead of a default path. The method may also include rewriting the DNS query such that the DNS query is routed through the alternative network device along the alternative path and to a DNS server associated with the alternative path. The method may additionally include receiving a DNS response from the DNS server, where a resource identified in the DNS response may be based on the DNS query coming through the alternative network device.

Abstract: Information from a variety of different sources may be used to enrich information about an object retrieved from a computing device/instance associated with a computing network (or web service provider). The additional information from the different sources provides to a user a more comprehensive set of information that may not be easily found (or even available) via sources associated with the computing network. As such, the additional information is beneficial in assisting users in making decisions regarding the purchase, licensing, and use of different objects (e.g. software, hardware, web services) associated with the computing network.

Abstract: The invention involves a method of producing 11-Hydroxy-THC by first creating a mixture of oil and cannabis material. This mixture is subjected to a simultaneous process of high pressurization and heat. Ideally the cannabis chosen is from a kief created by freezing a cannabis plant part and vibrating/screening the frozen cannabis plant part.

Abstract: A payee (300A) sends a financial document (335) such as an invoice to a payer (1A) via a payment adviser service (2001, 3001). The payer (1A) sends a financial document (45) such as an advice of payment to the payment adviser service (2001, 3001) and instructions for payment (80) to a payment clearance system (100). The payment clearance system sends to the payee (300A) information on where to access the financial document (45) by including it in the payee's bank statement (315).

Abstract: The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.

Abstract: An electrically operable clipper having a body portion and a head portion, wherein the head portion includes a movable cutter and a fixed comb. The clipper includes an internally located electric motor operable to move the movable cutter. The electric motor is provided with a first and second air moving structure operable to move air over and through the electric motor, in use.

Abstract: An electrically operable clipper has a body portion and a head portion, wherein the head portion includes a movable cutter and a fixed comb. The clipper includes an internally located electric motor operable to move the movable cutter. The clipper further includes an operating switch movable between an off position, an operating position and a reset position, wherein the reset position operates a motor reset module of the clipper.

Abstract: A payee (300A) sends a financial document (335) such as an invoice to a payer (1A) via a payment adviser service (2001, 3001). The payer (1A) sends a financial document (45) such as an advice of payment to the payment adviser service (2001, 3001) and instructions for payment (80) to a payment clearance system (100). The payment clearance system sends to the payee (300A) information on where to access the financial document (45) by including it in the payee's bank statement (315).

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies, wherein the disease is facioscapulohumeral muscular dystrophy (FSHD). It also relates to use of such compounds, or to methods of use of such compounds.