Patents by Inventor Roger Chen

Roger Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250027145
    Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.
    Type: Application
    Filed: March 21, 2024
    Publication date: January 23, 2025
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20250027148
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and insert-ing the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Application
    Filed: July 25, 2024
    Publication date: January 23, 2025
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20250028912
    Abstract: In general, techniques are described for various aspects of accessing datasets. A device comprising a memory configured to store the dataset, and a processor may be configured to perform the techniques. The processor may expose a language sub-surface specifying a natural language containment hierarchy defining a grammar for a natural language as a hierarchical arrangement of a plurality of language sub-surfaces. The processor may receive a query to access the dataset, the query conforming to a portion of the natural language provided by the exposed language sub-surface. The processor may transform the query into one or more statements that conform to a formal syntax associated with the dataset, access, based on the one or more statements, the dataset to obtain a query result, and output the query result.
    Type: Application
    Filed: June 24, 2024
    Publication date: January 23, 2025
    Inventors: Jignesh Patel, Junda Chen, Dylan Paul Bacon, Jiatong Li, Ushmal Ramesh, Rogers Jeffrey Leo John
  • Publication number: 20240377755
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Application
    Filed: July 22, 2024
    Publication date: November 14, 2024
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen
  • Patent number: 12077817
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: September 3, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Randall Davis, Roger Chen
  • Patent number: 12044977
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: July 23, 2024
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen
  • Patent number: 11965210
    Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 23, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20230367229
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Application
    Filed: July 26, 2023
    Publication date: November 16, 2023
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen
  • Publication number: 20230350561
    Abstract: Systems and methods are provided for improved graphical user interfaces. The system enables multiple separate applications, each of which may typically be in their own separate window or tab, to be interacted within a single window, such as a tab of a web browser application. The main window includes smaller sub-windows that can correspond to a distinct application with its own graphical user interface. A large sub-window within the main window is opened for the primary application where the user is currently interacting with a graphical user interface of the primary application. The user then is able to switch between applications (all within the same main window) and applications that are no longer being used can be minimized in smaller sub-windows off to the side of the primary sub-window. The system enables a user to drag and drop an item from one sub-window to another sub-window. Some of the interactions between the windows and data transformations are stored and can be visually presented in a graph.
    Type: Application
    Filed: July 3, 2023
    Publication date: November 2, 2023
    Inventors: Adam Storr, Aditya Dahiya, Andrew Elder, Daniel Cervelli, Joseph Rafidi, Matthew Bango, Parvathy Menon, Roger Chen, Timothy Slatcher, Walker Burgin
  • Patent number: 11733856
    Abstract: Systems and methods are provided for improved graphical user interfaces. The system enables multiple separate applications, each of which may typically be in their own separate window or tab, to be interacted within a single window, such as a tab of a web browser application. The main window includes smaller sub-windows that can correspond to a distinct application with its own graphical user interface. A large sub-window within the main window is opened for the primary application where the user is currently interacting with a graphical user interface of the primary application. The user then is able to switch between applications (all within the same main window) and applications that are no longer being used can be minimized in smaller sub-windows off to the side of the primary sub-window. The system enables a user to drag and drop an item from one sub-window to another sub-window. Some of the interactions between the windows and data transformations are stored and can be visually presented in a graph.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: August 22, 2023
    Assignee: Palantir Technologies Inc.
    Inventors: Adam Storr, Aditya Dahiya, Andrew Elder, Daniel Cervelli, Joseph Rafidi, Matthew Bango, Parvathy Menon, Roger Chen, Timothy Slatcher, Walker Burgin
  • Patent number: 11726408
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: August 15, 2023
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen
  • Patent number: 11608523
    Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: March 21, 2023
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, ROCHE SEQUENCING SOLUTIONS, INC.
    Inventors: Jingyue Ju, Randall Davis, Roger Chen
  • Publication number: 20230074871
    Abstract: A method is disclosed, as well as systems, performed by one or more processors, for interacting with data in a data repository. The method comprises receiving, in a data catalogue environment, a search request relating to one or more items in the data repository and determining an object type associated with the one or more items. Other operations comprise loading an object template in dependence on the determined object type, populating the template with data from the data repository in dependence on the search request to create an object view, and displaying the object view within the data catalogue environment. The data repository comprises a plurality of joined datasets, and wherein the object view comprises one or more links to items in a joined dataset.
    Type: Application
    Filed: November 11, 2022
    Publication date: March 9, 2023
    Inventors: Tony Poor, Alessandro Mingione, Roger Chen, Richard Wu, Sebastian Brueckner
  • Publication number: 20230010193
    Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.
    Type: Application
    Filed: July 1, 2022
    Publication date: January 12, 2023
    Applicants: The Trustees of Columbia University in the City of New York, Roche Sequencing Solutions, Inc.
    Inventors: Carl W. Fuller, Shiv Kumar, Jingyue Ju, Randall Davis, Roger Chen
  • Patent number: 11544325
    Abstract: A method is disclosed, as well as systems, performed by one or more processors, for interacting with data in a data repository. The method comprises receiving, in a data catalogue environment, a search request relating to one or more items in the data repository and determining an object type associated with the one or more items. Other operations comprise loading an object template in dependence on the determined object type, populating the template with data from the data repository in dependence on the search request to create an object view, and displaying the object view within the data catalogue environment. The data repository comprises a plurality of joined datasets, and wherein the object view comprises one or more links to items in a joined dataset.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: January 3, 2023
    Assignee: Palantir Technologies Inc.
    Inventors: Tony Poor, Alessandro Mingione, Roger Chen, Richard Wu, Sebastian Brueckner
  • Patent number: 11505827
    Abstract: Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 22, 2022
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Timothy Geiser, Randall Davis, Roger Chen
  • Publication number: 20220357652
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Application
    Filed: July 27, 2022
    Publication date: November 10, 2022
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen
  • Publication number: 20220331801
    Abstract: A system for processing a sample includes a chamber having at least one inlet and at least one outlet, where the chamber is configured to accommodate flow of the sample from the at least one inlet toward the at least one outlet, and an imager array configured to image the flow of the sample in the chamber, where the imager array includes at least one lensless image sensor configurable opposite at least one light source.
    Type: Application
    Filed: November 24, 2021
    Publication date: October 20, 2022
    Inventors: Leonard SHERMAN, Roger CHEN, Jonathan F. HULL
  • Publication number: 20220333187
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Application
    Filed: March 4, 2022
    Publication date: October 20, 2022
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Randall DAVIS, Roger CHEN
  • Patent number: 11402747
    Abstract: Examples of a multiple-mask multiple-exposure lithographic technique and suitable masks are provided herein. In some examples, a photomask includes a die area and a stitching region disposed adjacent to the die area and along a boundary of the photomask. The stitching region includes a mask feature for forming an integrated circuit feature and an alignment mark for in-chip overlay measurement.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: August 2, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.
    Inventors: Peter Yu, Chih-Tung Hsu, Kevin Wang, Chih-Chia Hu, Roger Chen