Abstract: A voltage controlled delay line (VCDL). The VCDL includes one or more cells. Each of the one or more cells includes two or more inputs and an output. Each of the one or more cells is configured to provide a delay as well as an interpolation function and a multiplexer function. The VCDL may be used to provide delay in a delay locked loop (DLL).

Abstract: A driver circuit. In one embodiment, the driver circuit includes a plurality of pull-up circuits and a plurality of pull-down circuits. The driver circuit also includes control logic that is coupled to activate/deactivate the pull-up and pull-down circuits. The driver circuit may perform emphasized signal transmissions having a voltage swing of a first magnitude or de-emphasized signal transmissions having a voltage swing of a second magnitude, wherein the first magnitude is greater than the second magnitude. The control logic is further configured to activate and/or deactivate pull-up and/or pull-down circuits such that the driver circuit output impedance in the emphasized mode is substantially equal to the output impedance in the de-emphasized mode.

Abstract: A voltage controlled delay line (VCDL). The VCDL includes one or more cells. Each of the one or more cells includes two or more inputs and an output. Each of the one or more cells is configured to provide a delay as well as an interpolation function and a multiplexer function. The VCDL may be used to provide delay in a delay locked loop (DLL).

Abstract: The invention is related to an oral immediate release formulation of Benzazepin-1-acetic acid derivatives comprising a) said active substance in an amount of up to 65% of the total weight of the formulation; b) at least 10% w/w an alkaline compound or a mixture of alkaline compounds; c) between 0.1 and 10% of one or more surfactants, and d) optionally comprises auxiliary materials an amount of between 1% and 45% of the total weight of the formulation.

Abstract: Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.

Abstract: The invention provides a method and apparatus for performing selective hypothermia to the brain and spinal cord for injury protection without the need for systemic cooling. A flexible catheter is inserted into the cerebral lateral ventricle or spinal subdural space. The catheter has three lumens with a heat transfer element. Two lumens of the catheter circulate a coolant and communicate at the distal heat transfer element for transfer of heat from the cerebrospinal fluid. The third lumen of the catheter allows for drainage of the cerebrospinal fluid. In another embodiment, the catheter has two lumens that circulate the coolant and communicate at the distal heat tranfer element. In another embodiment, a larger surface area cooling template is placed in the subdural space of the brain or the subdural/epidural space of the spine. The template has a conduit that circulates a coolant through the lumen of the template thereby cooling the surrounding brain or spinal cord.

Abstract: Spinal column stabilization method and devices are described. The devices comprise of a plate, bone screws, a distractor/compressor, and locking screws. Variations in the locking screws and plates provide for fixed or variable angle screw placement. Several variations of the bone and locking screws with capabilities of expansion of the bone screw head as well as the tips are disclosed. The bone screws, prior to placement of the locking screws, have a smaller diameter than the bone screw holes of the plate, which allows their placement prior to the plate, and therefore, the capability of also being used as compression and/or distraction screws. The locking screws expand the bone screw head securing it to the plate and also prevent screw back out.

Abstract: Fixation devices for stabilization and fusion of the lamina after laminoplasty are described. The device comprises of a plate with several holes that receive bone fasteners. The plate is curved at the ends to contour to the vertebral structure and has a spacer in the middle to engage the displaced lamina in a fixed position. Several fixation devices for dynamically stabilizing the lamina after either the open door, double door or expansive laminoplasty technique are provided.

Abstract: Fixation devices and methods for stabilization of the lamina after laminoplasty are described. The device comprises of a plate with several holes that receive bone fasteners. The plate is curved at the ends to contour to the vertebral structure and has appendages to engage the displaced lamina in a fixed position. Alternatively, the plate has a bone fusion spacer in the middle to engage and fuse the lamina in the displaced position. Several methods of dynamically stabilizing the lamina after either the open door, double door or expansive laminoplasty technique are provided.

Abstract: Fixation devices for stabilization and fusion of the lamina after laminoplasty are described. The device comprises of a plate with several holes that receive bone fasteners. The plate is curved at the ends to contour to the vertebral structure and has a spacer in the middle to engage the displaced lamina in a fixed position. Several fixation devices for dynamically stabilizing the lamina after either the open door, double door or expansive laminoplasty technique are provided.

Abstract: Pyrazole-thiazole compounds that modulate and/or inhibit the activity of cyclin-dependent kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating cyclin-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: The invention provides a method and apparatus for performing selective hypothermia to the brain and spinal cord for injury protection without the need for systemic cooling. A flexible catheter is inserted into the cerebral lateral ventricle or spinal subdural space. The catheter has three lumens with a heat transfer element. Two lumens of the catheter circulate a coolant and communicate at the distal heat transfer element for transfer of heat from the cerebrospinal fluid. The third lumen of the catheter allows for drainage of the cerebrospinal fluid. In another embodiment, the catheter has two lumens that circulate the coolant and communicate at the distal heat tranfer element. In another embodiment, a larger surface area cooling template is placed in the subdural space of the brain or the subdural/epidural space of the spine. The template has a conduit that circulates a coolant through the lumen of the template thereby cooling the surrounding brain or spinal cord.

Abstract: Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: Pyrazole-thiazole compounds that modulate and/or inhibit the activity of cyclin-dependent kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating cyclin-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: A two-component, heat reactive patch particularly useful for sealing gage and drain holes in automobile bodies which comprises an ionomer component and an olefinic/elastomeric component. The ionomer component contains an ionomeric copolymer of ethylene and an .alpha.,.beta.-ethylenically-unsaturated C.sub.3 -C.sub.8 carboxylic acid, a metallic coagent and a filler and, optionally, a non-ionomeric copolymer of ethylene. The olefinic/elastomeric component contains an uncrosslinked elastomer, a multifunctional acrylic monomer, and a free-radical curing agent.