Abstract: Disclosed are a display substrate and a display apparatus, the display substrate includes a display region and a non-display region, the display substrate includes a base substrate and a circuit structure layer disposed on the base substrate, the circuit structure layer includes multiple pixel circuits arranged in an array and located in the display region and multiple drive circuits located in the non-display region.

Abstract: A display panel includes a display area and a peripheral area at least partially surrounding the display area. Along a first direction, the display area includes a first display area and a second display area located on both sides of the first display area. The display panel further includes a plurality of pads located in the peripheral area; a plurality of data lines located in the display area and extending along a second direction, where the plurality of data lines include a plurality of first data lines located in the first display area and a plurality of second data lines located in the second display area; and a plurality of transition lines located in the display area and electrically connected to the plurality of second data lines and the plurality of pads.

Abstract: Provided herein are compositions and methods for high resolution spatial transcriptomic and epigenomic co-profiling of a biological sample.

Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: Provided herein are compositions and methods for producing a high resolution spatial epigenomic map of a biological sample.

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.

Abstract: The present invention provides systems and methods for single-cell RNA sequencing. Embodiments of the methods of the present invention include the steps of: aligning a microwell array on top of a dielectrophoresis (DEP) single-cell-trapping nanowell array; loading a plurality of cells into the nanowell; applying electricity to the nanowell array to trap a quanta of cells equal to a quanta of electrode pairs in at least one nanowell of the nanowell array; discontinuing electricity to the nanowell array in order to transfer the loaded cells from the nanowells to the microwells; loading a plurality of barcoded beads into the microwells so that a single bead occupies each cell-loaded microwell; capturing RNA from the cells and retrieving the RNA-loaded beads; and, sequencing the captured RNA.

Abstract: The present invention discloses a determination method for a preferred habitat of fish and a terminal device, wherein the method comprises: acquiring parameter information of a water environment in which target fish is located, and establishing a 3D water environment model by utilizing the parameter information of the water environment; determining an ecological function of the target fish and constructing a bio-simulation model on the 3D water environment model by combining the ecological function; acquiring a movement locus of the target fish in the bio-simulation model and determining potential habitats of the target fish according to the movement locus; and determining the preferred habitat of the target fish from the potential habitats by utilizing a preference learning model based on a density accumulation method.

Abstract: The present disclosure relates generally to systems and methods for screening sample preparation conditions and, more specifically, high throughput screening of tissue sample preparation conditions.

Abstract: The present invention discloses a determination method for a preferred habitat of fish and a terminal device, wherein the method comprises: acquiring parameter information of a water environment in which target fish is located, and establishing a 3D water environment model by utilizing the parameter information of the water environment; determining an ecological function of the target fish and constructing a bio-simulation model on the 3D water environment model by combining the ecological function; acquiring a movement locus of the target fish in the bio-simulation model and determining potential habitats of the target fish according to the movement locus; and determining the preferred habitat of the target fish from the potential habitats by utilizing a preference learning model based on a density accumulation method.

Abstract: The present invention provides a QFN packaging structure and QFN packaging method. By providing the insulating layer on the outer side of the leads of the QFN packaging structure, a short circuit between the leads and the electromagnetic shielding layer can be prevented. In addition, the grounding lead is exposed from the insulating layer, such that the electromagnetic shielding layer is grounded via the grounding lead, thereby realizing the electromagnetic shielding design of the QFN packaging structure.

Abstract: An optical device includes a range finding module. The range finding module includes a first light condenser unit, a light emitting unit and a light receiving unit. The first light condenser unit defines an optical axis and a hole disposed along the optical axis. The first light condenser unit, the light emitting unit and the light receiving unit are sequentially arranged along the optical axis. The light is emitted by the light emitting unit, passes through the hole, reaches an object, is reflected by the object, is converged by the first light condenser unit and is received by the light receiving unit to generate an electrical signal.