Abstract: The present disclosure relates to a packaging structure and a method for forming the same. The packaging structure includes a frame, a chip, a pin structure, and a second molding layer. The frame includes a first molding layer and a base island running through the first molding layer along a first direction. The frame has an upper surface and a lower surface disposed opposed along the first direction. The chip is disposed on the lower surface of the frame and electrically connected to the base island. The pin structure is disposed on the lower surface of the frame and includes a plurality of pin rings nested in sequence, each of which includes a plurality of pins disposed around an outer circumference of the chip. The pins are electrically connected to the chip. The second molding layer covers the lower surface of the frame, the chip, and the pin structure.

Abstract: Disclosed are a display substrate and a preparation method therefor, and a display apparatus. The display substrate includes a fanout region, the fanout region includes a first transition region, an isolation dam region, and a second transition region. The fanout region includes a gate metal layer and a source-drain metal layer, the gate metal layer includes any one or more of following: a first gate metal layer, a second gate metal layer, and a third gate metal layer. The gate metal layer is provided with a power supply connection line, the source-drain metal layer is provided with a first power supply line, the first power supply line is disposed in the first transition region and the second transition region, a first power supply line of the first transition region and a first power supply line of the second transition region are interconnected through the power supply connection line.

Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

Abstract: A multi-level direct current converter, a voltage control method for a flying capacitor, and a control apparatus are provided. The multi-level direct current converter includes a controller, a flying capacitor, two switching transistor groups, and an inductor. The method for controlling a flying capacitor includes: in response to that an absolute value of a difference between a sampling voltage and a reference voltage of the flying capacitor is greater than a first threshold, adjusting a duty cycle difference between first switching transistors in two switching transistor groups or a phase difference between carriers of first switching transistors in two switching transistor groups based on a magnitude of an inductor current. According to this application, a voltage of the flying capacitor can be controlled, to improve operation stability of the multi-level direct current converter.

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: An optical device includes a range finding module. The range finding module includes a first light condenser unit, a light emitting unit and a light receiving unit. The first light condenser unit defines an optical axis and a hole disposed along the optical axis. The first light condenser unit, the light emitting unit and the light receiving unit are sequentially arranged along the optical axis. The light is emitted by the light emitting unit, passes through the hole, reaches an object, is reflected by the object, is converged by the first light condenser unit and is received by the light receiving unit to generate an electrical signal.

Abstract: A display panel includes a display area and a peripheral area at least partially surrounding the display area. Along a first direction, the display area includes a first display area and a second display area located on both sides of the first display area. The display panel further includes a plurality of pads located in the peripheral area; a plurality of data lines located in the display area and extending along a second direction, where the plurality of data lines include a plurality of first data lines located in the first display area and a plurality of second data lines located in the second display area; and a plurality of transition lines located in the display area and electrically connected to the plurality of second data lines and the plurality of pads.

Abstract: Disclosed are a display substrate and a display apparatus, the display substrate includes a display region and a non-display region, the display substrate includes a base substrate and a circuit structure layer disposed on the base substrate, the circuit structure layer includes multiple pixel circuits arranged in an array and located in the display region and multiple drive circuits located in the non-display region.

Abstract: Provided herein are compositions and methods for high resolution spatial transcriptomic and epigenomic co-profiling of a biological sample.

Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: Provided herein are compositions and methods for producing a high resolution spatial epigenomic map of a biological sample.

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.