Patents by Inventor Rong Fan
Rong Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150204864Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.Type: ApplicationFiled: February 23, 2015Publication date: July 23, 2015Applicant: Yale UniversityInventors: Rong Fan, Yao LU, Jonathan Chen
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Publication number: 20150204862Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.Type: ApplicationFiled: December 5, 2014Publication date: July 23, 2015Inventors: Rong Fan, Yao Lu, Jonathan Chen
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Publication number: 20150151964Abstract: A method for decreasing steam methane reformer (SMR) tube temperature is provided. The method can include the steps of introducing a hydrocarbon containing feed to be reformed to a plurality of SMR tubes in the presence of steam under conditions effective to produce hydrogen and carbon monoxide, monitoring the temperature of at least a plurality of the tubes within the SMR during operation, comparing the monitored temperature against a first predetermined value, and introducing an effective amount of water to a reformer tube when the monitored temperature of the reformer tube is at or above the predetermined value, such that the temperature of the reformer tube is reduced.Type: ApplicationFiled: December 4, 2013Publication date: June 4, 2015Applicant: L'Air Liquide Societe Anonyme Pour I'Etude et I'Exploitation des Procedes Georges ClaudeInventors: Taekyu KANG, Rong FAN, Pavol PRANDA, Hwanho KIM, Robert A. GAGLIANO
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Publication number: 20150151266Abstract: An apparatus for decreasing steam methane reformer (SMR) tube temperature is provided. The apparatus can include an SMR furnace, a monitoring system in communication with the SMR furnace and a water source in fluid communication with the SMR furnace. The SMR furnace includes a plurality of SMR tubes disposed within the SMR furnace. The monitoring system is configured to monitor the temperature of at least a plurality of SMR tubes and compare the temperature against a first predetermined value, and the water source is configured to introduce water to an SMR tube that has a temperature above the first predetermined value, such that the temperature of the SMR tube is reduced.Type: ApplicationFiled: December 4, 2013Publication date: June 4, 2015Applicant: L'Aire Liquide Societe Anonyme Pour l'Etude et l'Exploitation des Procedes Georges ClaudeInventors: Taekyu KANG, Rong FAN, Pavol PRANDA, Hwanho KIM, Robert A. GAGLIANO
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Publication number: 20150073161Abstract: A method of ice-crystal wall-breaking extraction of the pomelo peel essencial oil, including: first selecting a fresh pomelo, peeling off the outmost oil cell layer with a peeler, and collecting the cortex that is 1.5-2.5 mm thick; slowly freezing the pomelo peel oil cell layer at ?15° C. to ?30° C. to form ice crystal; breaking the pomelo peel ice crystal with a breaker; thawing the broken ice crystal, and then squeezing with a screw squeezer to obtain a squeezed mixed liquid; adding 3-4% by mass of the table salt to the squeezed mixed liquid, and standing to stratify at reduced pressure, thereby obtaining an oil-water mixture; distilling the mixed liquid at reduced pressure, and collecting the distillate to obtain an oil-water mixture that undergoes natural stratification; discarding the water layer, thereby obtaining the pomelo peel essential oil.Type: ApplicationFiled: December 18, 2012Publication date: March 12, 2015Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGYInventors: Dawen Sun, Xin'an Zeng, Zhong Han, Zhongyue Xu, Rong Fan
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Publication number: 20130343177Abstract: A switching system compatible with ATCA/ATCA 300 architecture and a method for improving switching bandwidth, including: a backplane, a plurality of node boards and at least two hub boards; the node boards are connected with the hub nodes through the backplane; each node board is connected with the at least two hub boards; different data is transmitted on at least two data links between the node boards and the at least two hub boards, and the at least two hub boards cooperate with each other to implement a data switching between the node boards.Type: ApplicationFiled: August 12, 2013Publication date: December 26, 2013Applicant: Huawei Technologies Co., Ltd.Inventors: Feng HONG, Cheng CHEN, Rong FAN
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Publication number: 20130298011Abstract: A presentation method comprises: a sender device capturing screen frames and transmitting the screen frames to a receiver device; the receiver device receiving the screen frames transmitted by the sender device and outputting the screen frames to a display device for displaying the screen frames; establishing a webpage server in the receiver device; and the receiver device storing the screen frames as web pages. Thereby, the audiences can use the browsers of mobile Internet devices to link with the webpage server and browse the web pages containing the presentation contents.Type: ApplicationFiled: May 3, 2013Publication date: November 7, 2013Applicant: Awind, IncInventors: Kuo-Lung CHANG, Jr-Rong FAN, Ping-Yang TU, Hsing-Yung WANG
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Publication number: 20130224776Abstract: The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PCan065 antibodies. The invention encompasses a method of producing the anti-PCan065 antibodies. Other aspects of the invention are a method of killing an PCan065-expressing cancer cell, comprising contacting the cancer cell with an anti-PCan065 antibody and a method of alleviating or treating an PCan065-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PCan065 antibody to the mammal.Type: ApplicationFiled: May 8, 2012Publication date: August 29, 2013Applicant: DIADEXUS, INC.Inventors: RONG A. FAN, KIRSTIN L. KRALL
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Patent number: 8513245Abstract: This invention relates to a pharmaceutical composition for preventing and curing myocardium ischemia and reducing area of myocardial infarction, its pharmaceutical preparation and applications. The composition includes (a) levocarnitine or its derivatives, and (b) trimetazidine or its medicative salts. The quantity of levocarnitine or its derivatives, and trimetazidine or its medicative salts in the composition is effective amount for treating myocardial ischemia and reducing the area of myocardial infarction.Type: GrantFiled: May 28, 2008Date of Patent: August 20, 2013Assignee: Changzhou Hi-Tech District Multiple Dimension Industry Technology Institute Co., Ltd.Inventors: Shuhua Gu, Changlin Mei, Dingfeng Su, Juan Du, Rong Fan
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Patent number: 8440453Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.Type: GrantFiled: January 3, 2008Date of Patent: May 14, 2013Assignee: The Regents of the University of CaliforniaInventors: Peidong Yang, Rohit Karnik, Kenneth Castelino, Rong Fan, Arun Majumdar
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Patent number: 8354231Abstract: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.Type: GrantFiled: January 4, 2010Date of Patent: January 15, 2013Assignee: Cal. Inst. Tech.Inventors: Gabriel A. Kwong, Ryan C. Bailey, Rong Fan, James R. Heath
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Publication number: 20120299425Abstract: A closed energy combined cycle system and an operation method. This includes a power supply mechanism, for providing a high voltage; a driving device, controlled by the high voltage of the power supply mechanism; and a power generation device, in which the driving device rotates the power generation device to generate power through a transmission shaft, and the power generated by the power generation device supplied to the power supply mechanism and a load, in which the driving device rotates the transmission shaft at a high rotational speed, the transmission shaft rotates the power generation device to generate the power. Power generation efficiency of the power generation device may be enhanced, thereby greatly improving overall efficiency of the system, and resources used by the driving device for rotating the power generation device may be reduced, thereby effectively reducing consumption of earth resources and providing earth environmental protection.Type: ApplicationFiled: May 22, 2012Publication date: November 29, 2012Applicant: SHEN YANG TECHNOLOGIES ENTERPRISE CO., LTD.Inventors: Hui Yen TSAI, Wen-Lon CHENG, Chiu-Rong FAN, Tien CHUANG
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Publication number: 20120299424Abstract: A transmission shaft is disposed between a driving device and at least one driven device. At least one centrifugal device is disposed on the transmission shaft. The centrifugal device generates a centrifugal force and applies an inertia affect formed by the centrifugal force to the transmission shaft, so as to drive the transmission shaft to rotate. Energy generated by the driven device is greater than energy consumed when the driving device drives the driven device, thereby effectively reducing the consumption of earth resources and effectively solving a problem of earth environmental protection.Type: ApplicationFiled: May 22, 2012Publication date: November 29, 2012Applicant: SHEN YANG TECHNOLOGIES ENTERPRISE CO., LTD.Inventors: Hui Yen TSAI, Wen-Lon CHENG, Chiu-Rong FAN, Tien CHUANG
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Patent number: 8280214Abstract: Nanoribbons and nanowires having diameters less than the wavelength of light are used in the formation and operation of optical circuits and devices. Such nanostructures function as subwavelength optical waveguides which form a fundamental building block for optical integration. The extraordinary length, flexibility and strength of these structures enable their manipulation on surfaces, including the precise positioning and optical linking of nanoribbon/wire waveguides and other nanoribbon/wire elements to form optical networks and devices. In addition, such structures provide for waveguiding in liquids, enabling them to further be used in other applications such as optical probes and sensors.Type: GrantFiled: November 13, 2006Date of Patent: October 2, 2012Assignee: The Regents of the University of CaliforniaInventors: Peidong Yang, Matt Law, Donald J. Sirbuly, Justin C. Johnson, Richard Saykally, Rong Fan, Andrea Tao
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Publication number: 20120171778Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.Type: ApplicationFiled: January 3, 2008Publication date: July 5, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Peidong Yang, Rohit Karnik, Kenneth Castelino, Rong Fan, Arun Majumdar
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Publication number: 20120135912Abstract: The invention provides novel 2D-VCAM-1 variant polypeptides and conjugates thereof that bind human VLA4. The invention also provides related polynucleotides, compositions, vectors, host cells, and methods.Type: ApplicationFiled: May 10, 2011Publication date: May 31, 2012Applicant: PERSEID THERAPEUTICS LLCInventors: MADAN M. PAIDHUNGAT, AMULYA NANISETTI, THOMAS BOUQUIN, KIM VILBOUR ANDERSEN, STEVEN J. CHAPIN, CLAUS KREBBER, RONG A. FAN, DANIEL MALASHOCK, AMY BRIDEAU-ANDERSEN, ERIK KARRER, BRUCE DEVENS, STEVEN H. BASS
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Patent number: 8173434Abstract: The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PCan065 antibodies. The invention encompasses a method of producing the anti-PCan065 antibodies. Other aspects of the invention are a method of killing an PCan065-expressing cancer cell, comprising contacting the cancer cell with an anti-PCan065 antibody and a method of alleviating or treating an PCan065-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PCan065 antibody to the mammal.Type: GrantFiled: October 14, 2010Date of Patent: May 8, 2012Assignee: Diadexus, Inc.Inventors: Rong A. Fan, Kirstin L. Krall
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Patent number: 8093628Abstract: Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches.Type: GrantFiled: February 7, 2008Date of Patent: January 10, 2012Assignee: The Regents of the University of CaliforniaInventors: Peidong Yang, Rongrui He, Joshua Goldberger, Rong Fan, Yiying Wu, Deyu Li, Arun Majumdar
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Publication number: 20110233512Abstract: Vertical integrated field effect transistor circuits and methods are described which are fabricated from Silicon, Germanium, or a combination Silicon and Germanium based on nanowires grown in place on the substrate. By way of example, vertical integrated transistors are formed from one or more nanowires which have been insulated, had a gate deposited thereon, and to which a drain is coupled to the exposed tips of one or more of the nanowires. The nanowires are preferably grown over a surface or according to a desired pattern in response to dispersing metal nanoclusters over the desired portions of the substrate. In one preferred implementation, SiCl4 is utilized as a gas phase precursor during the nanowire growth process. In place nanowire growth is also taught in conjunction with structures, such as trenches, while bridging forms of nanowires are also described.Type: ApplicationFiled: January 16, 2008Publication date: September 29, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Peidong Yang, Joshua Goldberger, Allon Hochbaum, Rong Fan, Rongrui He
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Patent number: 8022361Abstract: Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.Type: GrantFiled: October 28, 2008Date of Patent: September 20, 2011Assignee: The Regents of the University of CaliforniaInventors: Daojing Wang, Peidong Yang, Woong Kim, Rong Fan