Abstract: Provided herein, in some embodiments, are compositions and methods for producing a molecular expression map of a biological sample using Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq).

Abstract: Provided herein, in some embodiments, are high-throughput single-cell mRNA profiling methods that include freeze-thaw cycling as the means to release mRNA from cells.

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Abstract: A method for growing nanotubes via flow-regulated microfluidic electrochemical anodization, includes providing a microfluidic device having a fluid inlet; a fluid outlet; and a fluidic microchannel connecting the fluid inlet and outlet, wherein the microchannel includes a Pt cathode and a Ti anode separated by an electrical insulator; providing an electrolyte fluid flow through the microchannel; and providing an electrical current across the anode and cathode sufficient to cause electrochemical anodization growth of TiO2 nanotubes in the microchannel on a surface of the anode.

Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

Abstract: The present disclosure provides systems and methods for producing olefins via an oxidative coupling of methane (OCM) process. The systems and methods may comprise the use of a staged process comprising at least one non-adiabatic section that is in thermal communication with a heat transfer medium and at least one substantially adiabatic section. The systems and methods may also comprise the use of a diluent stream which may improve methane conversion in an OCM reactor and an ethylene/ethane ratio in a post-bed cracking unit. The methods and systems may further comprise injecting oxygen (O2) and a paraffin into a gas stream containing a radical transfer agent to provide a reaction mixture. The reaction mixture may be held in a vessel for a time period greater than an auto-ignition delay time (AIDT), such that the reaction mixture may ignite to liberate heat and convert to a product mixture comprising olefins.

Abstract: A method of forming a composite material includes: a) providing a substrate with fibres, lignin and hemicellulose; b) partially removing the lignin and hemicellulose from the substrate; and c) compressing the remaining substrate to form a compressed substrate. A composite material formed by the method is also provided.

Abstract: A circuit protection assembly has a protection element having a positive temperature coefficient of resistance and consisting of a polymer-based conductive composite material layer tightly clamped and fixed between two metal electrodes and a copper clad laminate having a through hole in a middle thereof, wherein the protection element is provided in the through hole, the copper clad laminate serves as a substrate for the circuit protection assembly and has an adhesive layer on an upper surface and a lower surface thereof, so as to cover the protection element in a space formed by the copper clad laminate and the upper and the lower adhesive layers. The protection element having a positive temperature coefficient of resistance is electrically connected to a protected circuit via a conductive part.

Abstract: The present invention relates to a method for operating a communication apparatus in a network comprising a plurality of communication nodes, upon reception of a message at the communication apparatus, the communication apparatus starting a retransmission delay being selected at random from a retransmission delay interval, said retransmission delay interval being dependent on at least one of a status of the communication apparatus and a property of the received message, the communication apparatus monitors retransmissions of said message by other communication nodes during said retransmission delay and the communication apparatus transmitting a retransmission of said message at the expiry of said retransmission delay if a statistic based on the retransmissions of said message by other communication nodes is below a threshold.

Abstract: A method of establishing a paid connection between multi-platforms, where a transmitting end application is installed in a transmitting end apparatus of a sharing source and a receiving end application is installed in a receiving end apparatus of a sharing target. When establishing a connection, the transmitting end application/receiving end application confirms whether a unique ID of the receiving end apparatus/transmitting end apparatus exists in an exception list, and confirms whether the receiving end application/transmitting end apparatus makes payment based on an operating system used by the transmitting end apparatus/receiving end application, in order to determine establishing a limited or an unlimited connection between the transmitting end apparatus and the receiving end apparatus.

Abstract: A presentation server establishes a network connection with a presentation device and a client device. The presentation server is able to receive frame data transmitted by the presentation device and pointer coordinates transmitted by the client device. Therefore, the presentation server is able to display a virtual pointer on the presentation frame according to the pointer coordinates, so that the participant can operate the pointing device of the client device to control the virtual pointer so as to participate effectively in the presentation and interact with the speaker.

Abstract: The present disclosure relates to an angstrom silver injection for a cancer inhibition, a preparation method and an application. A composition of the angstrom silver injection includes: angstrom-level elementary substance silver powder with a concentration between 0.005 g/L and 0.500 g/L, medicinal anhydrous fructose with a concentration between 0.5 g/L and 1.0 g/L; sterile distilled water with a. concentration between 998.500 g/L and 999.495 g/L. Tumor cell membrane surface has higher negative charge, and the increase of the negative charge on the membrane surface relates to acid mucopolysaccharide, DNA, and side chain charge of protein, especially to the increase or exposure of sialic acid. Angstrom silver and silver ions have positive charge to combine with the protein and nucleic acid molecule with negative charge inside and outside cells for interfering with synthesis of the protein and replication and transcription of the DNA to destroy normal life activity of cancerous cells.

Abstract: The present invention is a method of managing a neighbor table in a communication apparatus. The method includes the steps of the communication apparatus maintaining a neighbor table comprising a plurality of neighboring table entries corresponding to respective neighboring nodes being communication nodes in communication range of the communication apparatus. Upon determination that the neighbor table capacity has reached a threshold, replacing a first neighbor table entry corresponding to a first neighboring node from the neighbor table by a new neighbor table entry corresponding to a new neighboring node based on the determination that the new neighboring node is a communication partner.

Abstract: Provided herein, in some embodiments, are devices, systems and methods for high-throughput single-cell polyomics (e.g., genomic, epigenomic, proteomic and/or phenotypic profile) analyses.

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: A circuit protection assembly has a protection element having a positive temperature coefficient of resistance and consisting of a polymer-based conductive composite material layer tightly clamped and fixed between two metal electrodes and a copper clad laminate having a through hole in a middle thereof, wherein the protection element is provided in the through hole, the copper clad laminate serves as a substrate for the circuit protection assembly and has an adhesive layer on an upper surface and a lower surface thereof, so as to cover the protection element in a space formed by the copper clad laminate and the upper and the lower adhesive layers. The protection element having a positive temperature coefficient of resistance is electrically connected to a protected circuit via a conductive part.

Abstract: This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.

Abstract: An improved hydrogen generation system and method for using the same are provided. The system includes an HDS unit configured to remove sulfur, a first and second pre-reformers configured to pre-reform a process gas and fuel gas, respectively, a first and second heat exchangers configured to dry and heat the pre-reformed fuel gas, respectively, and a reformer configured to produce a syngas and flue gas. The method includes using a process stream selected from the group consisting of air, PSA off-gas, hydrocarbon gas, and combinations thereof to dry the fuel gas and using a process stream selected from the group consisting of the flue gas, the syngas, and combinations thereof to heat the dry fuel gas. The second pre-reformer is a low-pressure pre-reformer, so that the heat contents of the fuel gas is increased through converting heavy hydrocarbons in the fuel gas to CO and H2 by the second pre-reformer.

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Abstract: The present disclosure provides systems and methods for producing olefins via an oxidative coupling of methane (OCM) process. The systems and methods may comprise the use of a staged process comprising at least one non-adiabatic section that is in thermal communication with a heat transfer medium and at least one substantially adiabatic section. The systems and methods may also comprise the use of a diluent stream which may improve methane conversion in an OCM reactor and an ethylene/ethane ratio in a post-bed cracking unit. The methods and systems may further comprise injecting oxygen (O2) and a paraffin into a gas stream containing a radical transfer agent to provide a reaction mixture. The reaction mixture may be held in a vessel for a time period greater than an auto-ignition delay time (AIDT), such that the reaction mixture may ignite to liberate heat and convert to a product mixture comprising olefins.