Abstract: Described herein are hydroxypyridine HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).

Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASHI, or drug induced liver injury (DILI).

Abstract: The present invention discloses a cell culture method for producing a CTLA-4 fusion protein composition comprising a target % of monomer species of the fusion protein, wherein the cell culture method comprises addition of cysteine in the cell culture medium. The invention further discloses a cell culture process to produce CTLA-4 fusion protein composition with target % of monomer species involving a dual temperature shift with addition of cysteine. Also, the present invention provides a CTLA-4 fusion protein composition comprised of target % of monomer species and/or homodimer species of the CTLA-4 fusion protein.

Abstract: A mobile x-ray device includes a telescopic column including a fixed portion and an telescopic portion vertically moveable relative to the fixed portion, a telescopic arm moveably connected to the upper telescopic portion of the telescopic column, a head assembly for obtaining x-ray images on the telescoping arm, a wire rope connected to the telescopic portion and the telescoping arm for providing the vertical movement of the telescopic portion and telescoping arm, and a counterbalancing mechanism for balancing the weight of the telescopic portion and the telescopic arm during movement thereof. The counterbalancing mechanism includes a block and tackle connected to the wire rope and a compression spring connected to and extending between the fixed portion and the block and tackle for storing potential gravitational energy of the telescopic portion and telescoping arm during either synchronous or non-synchronous movement of the upper telescopic portion and telescoping arm.

Abstract: Aspects of the present disclosure relate to methods, systems, and apparatus for conducting a radical treatment operation on a substrate prior to conducting an annealing operation on the substrate. In one implementation, a method of processing semiconductor substrates includes pre-heating a substrate, and exposing the substrate to species radicals. The exposing of the substrate to the species radicals includes a treatment temperature that is less than 300 degrees Celsius, a treatment pressure that is less than 1.0 Torr, and a treatment time that is within a range of 8.0 minutes to 12.0 minutes. The method includes annealing the substrate after the exposing of the substrate to the species radicals. The annealing includes exposing the substrate to molecules, an anneal temperature that is 300 degrees Celsius or greater, an anneal pressure that is within a range of 500 Torr to 550 Torr, and an anneal time that is less than 4.0 minutes.

Abstract: Aspects of a storage device are provided including improved victim zone selection for zone-based GC in ZNS. The storage device includes a NVM having first, second, and third blocks, and a controller. The controller creates a first superblock including the first blocks, a second superblock including the second blocks, and a third superblock including the third blocks. The controller determines whether a quantity of data overwrites associated with a first zone in the first superblock is larger than a quantity of data overwrites associated with a second zone in the first superblock. From the determination, the controller performs GC for the first zone prior to GC for the second zone, in which data overwrites associated with the first zone in the first superblock and sequential data associated with the first zone in the third superblock are relocated to the second superblock. Thus, storage device performance is improved and WAF reduced.

Abstract: Aspects of a storage device are provided including zone-based GC in a ZNS. The storage device includes a NVM and a controller. The NVM includes first blocks, second blocks, and third blocks. The controller creates a first superblock including the first blocks, a second superblock including the second blocks, and a third superblock including the third blocks. The controller allocates a first sub-drive including the first superblock for storing data overwrites and a second sub-drive including the second and third superblocks for storing sequential data in the NVM. During GC for superblocks respectively including data for a specific zone, the controller relocates written data for this zone from the first and third superblocks to the second superblock while refraining from relocating data associated with other zones from the first superblock to the second superblock. As a result, storage device cost, overprovisioning, and WAF may be reduced.

Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).

Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.

Abstract: In one embodiment, a method includes determining, by a router, a common prefix pool from a transport interface associated with a transport virtual private network (VPN). The method also includes identifying, by the router, a prefix associated with a service VPN and generating, by the router, an IPv6-to-IPv6 Network Address Translation (NAT66) prefix translation using the common prefix pool and the prefix. The NAT66 prefix translation includes a predetermined prefix length. The method further includes automatically installing, by the router, the NAT66 prefix translation into a translation table.

Abstract: A method comprises extracting first task data from a first data source corresponding to a first application and second task data from a second data source corresponding to a second application, and comparing the first task data to the second task data using one or more natural language processing techniques. In the method, one or more matching tasks between the first task data and the second task data are identified based at least in part on the comparing. Code of at least one of the first application and the second application is analyzed to determine whether the code of at least one of the first application and the second application implements the one or more matching tasks.

Abstract: The present invention discloses a method of cell culture for producing a fusion glycoprotein composition comprising a target glycosylation profile. More particularly, the invention provides a process to produce a glycoprotein composition from mammalian cell culture, wherein the composition comprises a target total sialylated and or di- and tri-sialylated N-glycan variant.

Abstract: A method and apparatus for forming a semiconductor device are provided. The method includes thermally treating a substrate having one or more silicon nanosheets formed thereon. Thermally treating the substrate includes positioning the substrate in a processing volume of a first processing chamber, the substrate having one or more silicon nanosheets formed thereon. Thermally treating the substrate further includes heating the substrate to a first temperature of more than about 250 degrees Celsius, generating hydrogen radicals using a remote plasma source fluidly coupled with the processing volume, and maintaining the substrate at the first temperature while concurrently exposing the one or more silicon nanosheets to the generated hydrogen radicals. The generated hydrogen radicals remove residual germanium from the one or more silicon nanosheets.

Abstract: Aspects of the present disclosure relate to methods, systems, and apparatus for conducting a radical treatment operation on a substrate prior to conducting an annealing operation on the substrate. In one implementation, a method of processing semiconductor substrates includes pre-heating a substrate, and exposing the substrate to species radicals. The exposing of the substrate to the species radicals includes a treatment temperature that is less than 300 degrees Celsius, a treatment pressure that is less than 1.0 Torr, and a treatment time that is within a range of 8.0 minutes to 12.0 minutes. The method includes annealing the substrate after the exposing of the substrate to the species radicals. The annealing includes exposing the substrate to molecules, an anneal temperature that is 300 degrees Celsius or greater, an anneal pressure that is within a range of 500 Torr to 550 Torr, and an anneal time that is less than 4.0 minutes.

Abstract: In one embodiment, a method includes determining, by a router, a common prefix pool from a transport interface associated with a transport virtual private network (VPN). The method also includes identifying, by the router, a prefix associated with a service VPN and generating, by the router, an IPv6-to-IPv6 Network Address Translation (NAT66) prefix translation using the common prefix pool and the prefix. The NAT66 prefix translation includes a predetermined prefix length. The method further includes automatically installing, by the router, the NAT66 prefix translation into a translation table.

Abstract: A method for automatically providing virtual support is provided. The method may include determining a level of experience associated with the end-user and members of a support personnel for a computer application. The method may further include, in response to detecting one or more first actions on the computer application, automatically generating and providing support instructions based on virtual support documentation to an end-user based on the one or more first actions and based on the level of experience associated with the end-user. The method may further include, in response to detecting one or more second actions on the computer application, automatically determining a match between a member of the support personnel and the end-user based on the level of experience associated with the end-user and the member of support personnel.

Abstract: During a garbage collection process of a data storage device, superblocks may be filled with dummy data, which may decrease device performance. Embodiments described herein provide systems, methods, and computer readable media for varying a size of a superblock to reduce or eliminate dummy data in a data storage device including a plurality of superblocks. Each of the plurality of superblocks including a plurality of die blocks.

Abstract: During a garbage collection process of a data storage device, superblocks may be filled with dummy data, which may decrease device performance. Embodiments described herein provide systems, methods, and computer readable media for varying a size of a superblock to reduce or eliminate dummy data in a data storage device including a plurality of superblocks. Each of the plurality of superblocks including a plurality of die blocks.

Abstract: Disambiguating question answering responses by receiving voice command data associated with a first user, determining a first user identity according to the first user voice command data, determining a first user activity context according to the first user voice command data, determining a first response for the first user, receiving voice command data associated with a second user, determining a second user identity according to the second user voice command data, determining a second user activity context according to the second user voice command data, determining a second response for the second user, determining a predicted ambiguity between the first response and the second response, altering the first response according to the predicted ambiguity, and providing the first response and the second response.

Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).