Abstract: Embodiments may comprise personal protective equipment with integrated physiological monitoring. Some embodiments may relate specifically to in-ear devices (such as hearing protection and/or communication devices) having one or more physiological sensors for early monitoring for heat related illnesses. Several embodiments may incorporate a temperature sensor and a speaker into such in-ear device.

Abstract: A piston prover apparatus, method and system for accurately measuring the flow rate of a fluid by the measurement of the position of an internal piston. The piston can be integrated with a poppet valve arrangement located within a cylinder in order to permit fluid (e.g., cryogenic fluid) to pass through an orifice passage when the piston is drawn to an upstream position prior to proving the flow. An actuator in association with a motor and an encoder can be located inside the cylinder. The motor drives the piston to the upstream position of the cylinder when a proving run is initiated. Once the piston is released for the proving run, the initial and final positions of the piston can be accurately measured along with the transit time.

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections.

Abstract: A piston prover apparatus, method and system for accurately measuring the flow rate of a fluid by the measurement of the position of an internal piston. The piston can be integrated with a poppet valve arrangement located within a cylinder in order to permit fluid (e.g., cryogenic fluid) to pass through an orifice passage when the piston is drawn to an upstream position prior to proving the flow. An actuator in association with a motor and an encoder can be located inside the cylinder. The motor drives the piston to the upstream position of the cylinder when a proving run is initiated. Once the piston is released for the proving run, the initial and final positions of the piston can be accurately measured along with the transit time.

Abstract: A small volume prover apparatus and method for precisely measuring the flow rate of a fluid via a cylindrical component such as a flow tube. A precision bore cylinder and a piston can be configured with a valve arrangement in order to permit fluid to pass through an annular passage when the piston travels from one position to an opposite position. An accelerometer sensor can be mounted to the piston for continuously detecting the velocity of the piston traveling in the pipe by integrating acceleration data with respect to time data. The volumetric flow rate can be automatically calculated by multiplying the velocity with respect to the area of the flow tube.

Abstract: A device includes a cartridge containing a filter material. An insert extends through at least a portion of the filter material. The insert has gas sample path with an opening to provide a sample of air that is representative of the saturation of the filter material. A return path may be included in the insert to return sampled gas to the filter material. A gas mask contains a gas sensor and coupled to the cartridge, which may be replaced when saturated.

Abstract: The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases).

Abstract: The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.

Abstract: The invention provides methods, compositions, and kits for the inhibition of members of the Rho GTPase family. Specifically, the invention provides methods, compositions and kits for the inhibition of RhoA and/or RhoC transcriptional signalling. The invention finds use in treatment of Rho-mediated disease states (e.g., tumor metastasis, inflammation, inflammatory disease), Rho-mediated biological conditions, and in cell signaling research.

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of arboviruses.

Abstract: An insertion instrument is configured to eject at least one anchor body into respective target locations, and subsequently apply a predetermined tensile force at least one actuation member of the at least one anchor member so as to actuate the at least one anchor body from a first configuration to a second expanded configuration. The insertion instrument can include a tension assembly that applies the predetermined tensile force to the at least one actuation member. The predetermined tensile force can be defined by a distance of travel, a predetermined failure force of a fuse, or a combination of distance of travel and a predetermined failure force of a fuse.

Abstract: An insertion instrument is configured to eject a pair of anchor bodies across an anatomical gap so as to approximate the gap. The insertion instrument can include a single cannula that retains the pair of anchor bodies in a stacked relationship, or a pair of adjacent cannulas that each retain respective anchor bodies. The insertion instrument can be actuated so as to eject the anchor bodies into respective target anatomical locations.

Abstract: An anchor assembly can include at least one anchor member, such as a pair of anchor members that are configured to be implanted in a target anatomical location in a first configuration, and can subsequently be actuated to an expanded configuration that secures the anchor members in the target anatomy. The anchor assembly can further include a connector member that attaches the pair of anchor members together across a gap so as to approximate the anatomical defect.

Abstract: A bi-directional suture passing instrument configured to approach soft tissues perpendicularly, enables safer and more efficient surgical repairs and minimally invasive techniques to be employed, useful in areas such as annulus repair, meniscal repair, shoulder arthroscopy, hernia repair, laproscopic repair, and wound closure.

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections.

Abstract: A controller including a controller input coupled to an engine magneto for monitoring tractor engine operation by monitoring a change in magneto signal thereby determining if the engine is running. A power output circuit coupled to an output from the controller draws current from a tractor battery for powering an auxiliary component when the tractor engine is running and disrupts power to the auxiliary component when the tractor engine is not running to conserve battery life.

Abstract: The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.

Abstract: By providing a shaver receiving and supporting housing which is constructed for enabling cleaning fluid to be delivered directly to the interior of a shaver in a highly efficient manner, a fully integrated shaving cleaning system is realized which is capable of providing automated cleaning of the shaver in an efficient and effective manner. In accordance with the present invention, the cleaning fluid if forced through portals formed in the shaver for enabling the fluid to be forcibly delivered directly into the hair pocket of the shaver, thereby enabling the surfaces of the hair pocket, the cutting foils, and the cutting blades to be completely and thoroughly cleaned, with the fluid draining out of the shaver through the cutting foils. In addition, the present invention is constructed for thoroughly and completely cleaning both rotary shavers and foil shavers.

Abstract: A guide assembly for facilitating placement of a fixation member within a medullary canal of a radius is provided. According to one embodiment, a guide assembly includes a guide fastener configured to attach to a fixation member and a guide member configured to receive the guide fastener such that the guide member is secured to the fixation member. The guide assembly also includes an interchangeable distal guide member configured to engage and be disengaged from the guide member. The distal guide member defines a plurality of fastener guide openings for guiding respective fasteners through a plurality of fastener openings defined in the fixation member.

Abstract: A controller including a controller input coupled to an engine magneto for monitoring tractor engine operation by monitoring a change in magneto signal thereby determining if the engine is running. A power output circuit coupled to an output from the controller draws current from a tractor battery for powering an auxiliary component when the tractor engine is running and disrupts power to the auxiliary component when the tractor engine is not running to conserve battery life.