Abstract: An anchor assembly can include at least one anchor member, such as a pair of anchor members that are configured to be implanted in a target anatomical location in a first configuration, and can subsequently be actuated to an expanded configuration that secures the anchor members in the target anatomy. The anchor assembly can further include a connector member that attaches the pair of anchor members together across a gap so as to approximate the anatomical defect.

Abstract: A bi-directional suture passing instrument configured to approach soft tissues perpendicularly, enables safer and more efficient surgical repairs and minimally invasive techniques to be employed, useful in areas such as annulus repair, meniscal repair, shoulder arthroscopy, hernia repair, laparoscopic repair, and wound closure.

Abstract: A device includes a cartridge containing a filter material. An insert extends through at least a portion of the filter material. The insert has gas sample path with an opening to provide a sample of air that is representative of the saturation of the filter material. A return path may be included in the insert to return sampled gas to the filter material. A gas mask contains a gas sensor and coupled to the cartridge, which may be replaced when saturated.

Abstract: A device for spinal surgery that may be used for tightening a locking cap onto at least a portion of a pedicle screw. The device may include a torque-generating body having a proximal end and an opposing distal end and a drive shaft rotatably driven by the torque-generating body. A proximal end of the drive shaft may be operatively engaged to the distal end of the torque-generating body and an opposing distal end of the drive shaft may engage at least a portion of one of the locking cap and the pedicle screw. An anti-torque device is provided that has an elongated and generally hollow member defining a longitudinal axis. The member has a proximal end and an opposing distal end, where the proximal end of the anti-torque device may be fixed from rotating relative to at least a portion of the torque-generating body and the distal end may be fixed from rotating relative to a spine rod or a pedicle screw.

Abstract: A human wearable mask includes a skirt for directly contacting a human wearer and a sound conduction component on the skirt. The sound conduction component can provide an alert notification within high-noise environments while allowing ambient sounds to be heard over the conduction speakers. The sound conduction component may be used to reproduce audio for firefighters and other users who need radio communications.

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox.

Abstract: Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox.

Abstract: Embodiments relate generally to systems and methods for determining end of service life for a respirator cartridge by comparing the gas levels sensed at two or more sample points within the cartridge. Sample streams may run from the sample points to a gas sensor, wherein a valve may control the flow between the sample streams and the gas sensor.

Abstract: The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases).

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of arboviruses.

Abstract: A guide assembly for facilitating placement of a fixation member within a medullary canal of a radius is provided. According to one embodiment, a guide assembly includes a guide fastener configured to attach to a fixation member and a guide member configured to receive the guide fastener such that the guide member is secured to the fixation member. The guide assembly also includes an interchangeable distal guide member configured to engage and be disengaged from the guide member. The distal guide member defines a plurality of fastener guide openings for guiding respective fasteners through a plurality of fastener openings defined in the fixation member.

Abstract: A guide assembly for facilitating placement of a fixation member within a medullary canal of a radius is provided. According to one embodiment, a guide assembly includes a guide fastener configured to attach to a fixation member and a guide member configured to receive the guide fastener such that the guide member is secured to the fixation member. The guide assembly also includes an interchangeable distal guide member configured to engage and be disengaged from the guide member. The distal guide member defines a plurality of fastener guide openings for guiding respective fasteners through a plurality of fastener openings defined in the fixation member.

Abstract: A method and apparatus including at least one anchor and at least one suture assembly. The anchor comprising a body and a suture capture element formed in the body for attaching at least one suture to the anchor The suture capture element being configured so as to permit the suture to be snared by the capture element after the anchor has been attached to bone. The suture assembly including a first loop and a second loop. The suture assembly being configured to attach to soft tissue or bone with at least one of the first and second loops disposed about the suture capture element of the anchor.

Abstract: The present disclosure relates to a human wearable mask includes a skirt for directly contacting a forehead of a human wearer, a patch with sensors on the skirt to obtain and provide temperature data from the forehead of the human wearer.

Abstract: A flame detector includes an infrared detector and a first window covering the infrared detector. A second window is positioned in front of the first window. The flame detector is adapted to reject light having a wavelength below approximately 2 ?m and to reject light having a wavelength above approximately 6 ?m, allowing detection of flame from multiple sources. In variations, the windows in combination with the infrared detector may provide the rejection or a band pass filter provides the rejection. Still further variations utilize notch filters or a band reject filter to provide notches of light to the infrared detector corresponding to the wavelength of different flame sources to be detected.

Abstract: A system includes a micro-optic array of pixel elements positioned to receive radiation from a flame. A mid-wave infrared (MWIR) detector is positioned to receive mid-wave infrared radiation from the micro-optic array. A filter is provided to pass mid-wave infrared radiation to the MWIR detector. A controller is provided to sequentially select different sets of pixel elements of the micro-optic array to provide mid-wave infrared radiation to the MWIR detector representative of the flame.

Abstract: Embodiments may comprise personal protective equipment with integrated physiological monitoring. Some embodiments may relate specifically to in-ear devices (such as hearing protection and/or communication devices) having one or more physiological sensors for early monitoring for heat related illnesses. Several embodiments may incorporate a temperature sensor and a speaker into such in-ear device.

Abstract: A piston prover apparatus, method and system for accurately measuring the flow rate of a fluid by the measurement of the position of an internal piston. The piston can be integrated with a poppet valve arrangement located within a cylinder in order to permit fluid (e.g., cryogenic fluid) to pass through an orifice passage when the piston is drawn to an upstream position prior to proving the flow. An actuator in association with a motor and an encoder can be located inside the cylinder. The motor drives the piston to the upstream position of the cylinder when a proving run is initiated. Once the piston is released for the proving run, the initial and final positions of the piston can be accurately measured along with the transit time.

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections.