Abstract: The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism.A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

Abstract: Disclosed are (1) an optical resin composition comprising Component A: a thiourethane prepolymer compound prepared by reacting a polythiol compound having at least 3 functional groups and an intramolecular sulfide bond, with a polyisocyanate compound in a molar ratio of --SH to --NCO ranging from 3.0 to 7.0; Component B: at least one (meth) acrylate compound having at least 2 functional groups; and Component C: a compound radically polymerizable with Components A and B, in 10 to 50% by weight, 35 to 70% by weight, and 5 to 30% by weight, respectively; (2) a preparation process for an optical resin by photopolymerization; (3) an optical resin; and (4) a prepolymer suitable for Component A. The composition is a novel, rapidly polymerizable composition for an optical resin. Furthermore, a resin prepared by curing the composition not only has a high refractive index and a high Abbe number, but also is excellent in transparency and optical homogeneity.

Abstract: Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): ##STR1## wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a --CONH-- group or a group represented by the formula --CR.sup.6 .dbd.CR.sup.7 -- in which R.sup.6 and R.sup.7 represents H, a lower alkyl group or the like, D represents an arylene group, a heteroarylene group or the like, n1 stands for 0 or 1, M represents, for example, a hydroxyl group or a lower alkoxy group; or a physiologically acceptable salt thereof. As a retinoic-related compound replacing retinoic acid, it permits the provision of a preventive and/or therapeutic for various diseases.

Abstract: Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

Abstract: A sulfur-containing O-(meth)acrylate compound of the following formula (1) is useful as a starting material for a resin composition used in optical applications such as a lens; ##STR1## wherein R represents hydrogen atom or methyl group; 1 represents an integer from 1 to 3; B is ##STR2## n is 1 or 2, m is 1, 2 or 3 and A is selected from certain arylene, aralkylene, thioether, dithioether or thiopheneylene radicals.

Abstract: A pen cap having at least two engaging portions (59f, 59r) specifically adapted to engage a receiving-side engaging portion (51f) formed on the mouthpiece-side end (7) of a hollow barrel and a receiving-side engaging portion (51r) formed on the tail-plug-side end of the hollow barrel (9), respectively. The engaging portions on the cap are at different locations along the cap's longitudinal axis. Furthermore, the engaging portions on the cap have their engaging surfaces disposed radially outward at different distances relative to the cap's longitudinal axis.

Abstract: The multiplex writing implement includes: a cylindrical portion formed in the rear of the elliptical cylinder portion of the middle barrel; a rotary shaft which is disposed in the bore of the cylindrical portion so as to rotate in a range of about 180.degree.

Abstract: Disclosed are: (1) an optical resin composition comprising Component A: a thiourethane prepolymer compound prepared by reacting a polythiol compound having at least 3 functional groups and an intramolecular sulfide bond, with a polyisocyanate compound in a molar ratio of --SH to --NCO ranging from 3.0 to 7.0 Component B: at least one (meth)acrylate compound having at least 2 functional groups; and Component C: a compound radically polymerizable with Components A and B, in 10 to 50% by weight, 35 to 70% by weight, and 5 to 30% by weight, respectively; (2) a preparation process for an optical resin by photopolymerization; (3) an optical resin; and (4) a prepolymer suitable for Component A. The composition is a novel, rapidly polymerizable composition for an optical resin. Furthermore, a resin prepared by curing the composition not only has a high refractive index and a high Abbe number, but also is excellent in transparency and optical homogeneity.

Abstract: A multiplex writing implement of the invention has a multiple number of writing elements, including at least one ball-point pen element which is filled up with a thixotropic water-soluble or low-viscosity oil-based ball-point ink. The ink reserving portion of the ink reservoir of the ball-point pen element is non-flexible and has a relatively large cross-section. A portion for jointing the point assembly with the ink reserving portion is formed so that the element can readily be deflected transversely with respect to the axial direction. The writing tip portions of these writing elements can selectively be projected from and retracted into the barrel front. This multiplex writing implement is able to create line traces with thick line density without causing any blobbing of ink or ink starving. It is also possible to prevent accidental ink leakage. That is, ink can be prevented from staining the barrel cylinder, user's hands, clothes etc.

Abstract: A communication system comprising a plurality of network elements and a monitoring apparatus for centrally monitoring and controlling these network elements. Each of the network elements has a plurality of CPU's and a flash memory for accommodating programs to be performed by the CPU's. The monitoring apparatus includes a database, a management unit and a transfer unit. The database retains a plurality of programs for each of the CPU's in each network element, and generic issues defined uniquely corresponding to combinations of versions of programs to be executed by each CPU. When the version of any program is changed, the management unit selects the program to be transferred in accordance with the applicable generic issue. The transfer unit transfers the program thus selected to the monitoring apparatus.

Abstract: A composite writing instrument comprising a writing instrument mechanism having a plurality of refills and a rod-like delivery mechanism, the composite writing instrument comprising middle shaft provided between a front shaft and a rear shaft, return springs having one end terminated at the middle shaft to urge the refills, respectively, backward; sliding cams mounted at rear portions of the refills and terminated at the other ends of the return springs to be urged backward, a cam body having at a front portion a cam operating portion which presses the rear end of either of the sliding cams to selectively advance the refills; a guide tube rotatably engaging the cam body and having a guide groove in the axial direction; a slider formed in the guide tube holding a rod-like article and being slidable in the axial direction along the guide groove of the guide tube, the cam body being provided with an engaging portion which engages the middle shaft so as to be slidable in the direction of the front shaft and be ro

Abstract: Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.

Abstract: In a servomechanism which includes a motor and performs positioning control and velocity control, based on a response of the motor when a step command is supplied in a condition where a load is applied to the motor, the value of the load is estimated, and the servo-gain of the servomechanism is automatically set in accordance with the estimated load value. Load inertia of the servomechanism is automatically calculated, an optimum gain is automatically set based on the calculation result, and a test operation is performed, so that a time period required for the adjustment can be shortened.

Abstract: Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.

Abstract: A composition for optical materials is herein disclosed which comprises the following two components (a) and (b):(a) a component containing at least one of poly isocyanates represented by the formula (1) ##STR1## wherein A is an alkanediyl group or an alkanetetrayl group which may contain a sulfur atom, or a dithianetetrayl group, and the alkanediyl group or the alkanetetrayl group may be substituted by a phenyl group; B is a methylene chain represented by .paren open-st.CH.sub.2 .paren close-st..sub.m (m is an integer of 1 to 4) which may contain a sulfur atom, and B's may be the same or different; and n is an integer of 2 or 4, and(b) a component containing at least one of polythiols having two or more mercapto groups. The composition is useful to provide optical products such as plastic lenses, filters, substrates for recording media and optical fibers which have a very high refractive index and which are excellent in heat resistance.

Abstract: Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

Abstract: A ball-point pen capable of preventing back leakage of ink when the pen is used to write with the ball-point tip above the ink reservoir. The pen has a ball-point tip (15); an ink reservoir (17) and a joint (19) connecting the ink reservoir with the tip for delivering ink to the tip. The joint has a tip-side bore (37a) and reservoir-side bore (33a) connected by a communicating hole (45), for allowing ink to pass from the reservoir-side bore to the tip-side bore. The communicating hole (45) is composed of a large-diameter portion (45b) and a small-diameter portion (45s) connected to the tip-side bore and the reservoir-side bore, respectively, and is eccentric to both bores. A ball 49 having a greater diameter than the bore diameter of the small-diameter portion is disposed to be freely movably in at least a part of a space formed between the rear end of the tip and the large diameter portion when the tip is fitted into the tip-side bore.

Abstract: A ballpoint pen for use with ink having thixotropic (shear viscosity decreasing properties) and a joint for regulating the flow of the ink to the pen's tip through an entrance in the tip. The joint includes a valve chamber which is disposed in an approximately middle portion of the joint with respect to the axial direction thereof for holding a ball therein with play and has a ball seat in the rear part thereof, a cavity in front of the valve chamber and a conduit communicating with an ink reservoir.

Abstract: A composition for a urethane-base plastic lens, comprising:(a) at least one ester compound selected from the group consisting of isocyanate compounds, isothiocyanate compounds and isocyanato-containing isothiocyanate compounds,(b) at least one active hydrogen compound selected from the group consisting of hydroxyl compounds, mercapto compounds and mercapto-containing hydroxyl compounds,(c) a tertiary amine, and(d) a Lewis acid;a plastic lens obtained by heating and curing the composition, and a process for the production of the plastic lens. The composition has a long pot life and can produce an optically uniform plastic lens in a short time.

Abstract: Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.