Abstract: The present invention relates generally to a method of prognosing the survival of a patient with a breast neoplasm, more particularly a patient with a breast neoplasm which is estrogen receptor-/progesterone receptor-/HER-2-(“triple-negative”). The method of the present invention more particularly provides a method for prognosing breast cancer patient survival, in particular risk of metastatic spread, by screening for IRF9 expression. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating patients with a triple-negative breast neoplasm, in particular those patients with triple-negative breast neoplasia which is characterised by a poor survival prognosis, still more particularly a high risk of metastatic spread, by upregulating type I IFN levels.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: Provided is a travel head support garment comprising a torso covering configured to cover at least a portion of a wearer's torso, in use, and having a head engager configured to selectively engage a wearer's head. Further included are at least one strap connected to the head engager and running down the wearer's torso, and a seating pad fastened with the strap and deployable between a storage position, in which the seating pad is stored within the torso covering, and a deployed position, in which the seating pad extends below the wearer's torso so that a wearer is able to sit on the seating pad so that the weight of the wearer on the seating pad supports the wearer's head via the strap 22, against gravity to alleviate loading of at least one muscle in the wearer's neck to unobtrusively support the wearer's head without conscious effort by the wearer.

Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: Provided herein are system, methods and computer program products for identifying duplicate records stored in a database system, comprising: generating a plurality of encrypted match indexes for each of a plurality of records stored in the database system, each of the plurality of encrypted match indexes encrypts a value of each encryption enabled field of a respective one of the plurality of records defined by at least one match rule, creating a cluster of records comprising at least one set containing at least two records of the plurality of records, the at least two records having respective encrypted match indexes corresponding to the at least one match rule, causing identification of duplicate records in the at least one set according to detection of records of the at least one set having respective match indexes matching the at least one match rule, and outputting an indication of the identified duplicate records.

Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: Disclosed herein are system, method, and computer program product embodiments for detecting duplicates with exact and fuzzy matching on encrypted match indexes using an encryption key in a cloud computing platform. An embodiment operates by determining a match rule index value upon reception of a new record. The embodiment encrypts the match index rule value using the customer's encryption key and a deterministic encryption method and stores the encrypted match rule index value. Duplicate detection may be later performed by using the same deterministic encryption method to determine a cypher text for a candidate entry and comparing the ciphertext to the stored encrypted match indexes.

Abstract: A method and system of designing control logic for an avionics system, the method and system including receiving a function requirement defining a desired control logic for the desired control system, designing, by a user in a user interface (UI) of a toolset, the desired control logic comprising an arrangement of predefined library blocks to enable the functional requirement in the desired control system, and generating, by the toolset, a data file representative of the desired control logic to enable the functional requirement during run-time operation in the avionics system.

Abstract: Colloidal silver particles are incorporated into emulsions and other compositions that find use, for example, as pharmaceutical and dermatological serums, creams, lotions and ointments.

Abstract: The baseball/softball hitting training device includes a base, a frame body, and a ball suspension system. The ball suspension system is supported by the frame body. The frame body includes a vertical stem portion and an offset portion. An upwardly-projecting arm of the vertical stem and a downwardly-projecting arm of the offset portion define a vertical axis between them. The ball suspension system is supported between the upwardly-projecting arm and downwardly-projecting arm, with the ball held vertically intermedially via a tether in alignment with the vertical axis and positioned to allow the player to practice hitting. In some aspects, a height-adjustment mechanism and/or additional coupling assemblies are also disclosed. The tethered-ball training device can optionally be converted to a tee-ball training device.

Abstract: Disclosed herein are system, method, and computer program product embodiments for detecting duplicates with exact and fuzzy matching on encrypted match indexes using an encryption key in a cloud computing platform. An embodiment operates by determining a match rule index value upon reception of a new record. The embodiment encrypts the match index rule value using the customer's encryption key and a deterministic encryption method and stores the encrypted match rule index value. Duplicate detection may be later performed by using the same deterministic encryption method to determine a cypher text for a candidate entry and comparing the ciphertext to the stored encrypted match indexes.

Abstract: The baseball/softball hitting training device includes a base, a frame body, and a ball suspension system. The ball suspension system is supported by the frame body. The frame body includes a vertical stem portion and an offset portion. An upwardly-projecting arm of the vertical stem and a downwardly-projecting arm of the offset portion define a vertical axis between them. The ball suspension system is supported between the upwardly-projecting arm and downwardly-projecting arm, with the ball held vertically intermedially via a tether in alignment with the vertical axis and positioned to allow the player to practice hitting. In some aspects, a height-adjustment mechanism and/or coupling assemblies are also disclosed. The tethered-ball training device can optionally be converted to a tee-ball training device.

Abstract: Methods, systems, and devices for distributed caching of encrypted encryption keys are described. Some multi-tenant database systems may support encryption of data records. To efficiently handle multiple encryption keys across multiple application servers, the database system may store the encryption keys in a distributed cache accessible by each of the application servers. To securely cache the encryption keys, the database system may encrypt (e.g., wrap) each data encryption key (DEK) using a second encryption key (e.g., a key encryption key (KEK)). The database system may store the DEKs and KEKs in separate caches to further protect the encryption keys. For example, while the encrypted DEKs may be stored in the distributed cache, the KEKs may be stored locally on application servers. The database system may further support “bring your own key” (BYOK) functionality, where a user may upload a tenant secret or tenant-specific encryption key to the database.

Abstract: Methods, systems, and devices for distributed caching of encrypted encryption keys are described. Some multi-tenant database systems may support encryption of data records. To efficiently handle multiple encryption keys across multiple application servers, the database system may store the encryption keys in a distributed cache accessible by each of the application servers. To securely cache the encryption keys, the database system may encrypt (e.g., wrap) each data encryption key (DEK) using a second encryption key (e.g., a key encryption key (KEK)). The database system may store the DEKs and KEKs in separate caches to further protect the encryption keys. For example, while the encrypted DEKs may be stored in the distributed cache, the KEKs may be stored locally on application servers. The database system may further support “bring your own key” (BYOK) functionality, where a user may upload a tenant secret or tenant-specific encryption key to the database.

Abstract: Colloidal silver particles and cannabinoids are incorporated into emulsions and other compositions that find use, for example, as pharmaceutical and dermatological serums, creams, lotions and ointments.

Abstract: A cooling arrangement for a turbine engine includes a cooling source and first and second structures. A ceramic-based composite cooling tube fluidly provides a fluid connection between the first and second structures. The cooling tube is configured to transfer a cooling fluid from the cooling source to the second structure.

Abstract: The baseball/softball hitting training device includes a base, a frame body, and a ball suspension system. The ball suspension system is supported by the frame body. The frame body includes a vertical stem portion and an offset portion. An upwardly-projecting arm of the vertical stem and a downwardly-projecting arm of the offset portion define a vertical axis between them. The ball suspension system is supported between the upwardly-projecting arm and downwardly-projecting arm, with the ball held vertically intermedially via a tether in alignment with the vertical axis and positioned to allow the player to practice hitting. In some aspects, a height-adjustment mechanism and/or coupling assemblies are also disclosed. The tethered-ball training device can optionally be converted to a tee-ball training device.