Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a handle and treatment tip that has both an energy delivery element and a cooling mechanism. The handle may be a two-handed handle allowing control even while rotating and maneuvering the treatment around the genital opening. The apparatus or system may also include an integrated controller, which may confirm tissue contact without applying RF energy, based only on the temperature of the applicator and the time since the last application of energy from the applicator.

Abstract: Disclosed herein are system, method, and computer program product embodiments for detecting duplicates with exact and fuzzy matching on encrypted match indexes using an encryption key in a cloud computing platform. An embodiment operates by determining a match rule index value upon reception of a new record. The embodiment encrypts the match index rule value using the customer's encryption key and a deterministic encryption method and stores the encrypted match rule index value. Duplicate detection may be later performed by using the same deterministic encryption method to determine a cypher text for a candidate entry and comparing the ciphertext to the stored encrypted match indexes.

Abstract: The present invention relates generally to a method of diagnosing, prognosing or monitoring the development or progress of metastatic cancer, more particularly bone metastatic cancer. The method of the present invention more particularly provides a method for detecting metastatic cancer, or a predisposition thereto, by screening for the differential expression of a panel of genes which comprise an IRF7 binding site. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating metastatic cancer, in particular bone metastatic cancer. More particularly, the present invention provides a means of therapeutically or prophylactically treating metastatic cancer by upregulating type I IFN levels.

Abstract: A pressure sensor includes a first plate (102), a second plate (104) and a foam (106) disposed between the first and second plate. The foam is a polyurethane foam having an average cell size of about 50 to 250 urn and a density of between 5 to 30 lbs/ft3.

Abstract: The present invention relates generally to a method of diagnosing, prognosing or monitoring the development or progress of metastatic cancer, more particularly bone metastatic cancer. The method of the present invention more particularly provides a method for detecting metastatic cancer, or a predisposition thereto, by screening for the differential expression of a panel of genes which comprise an IRF7 binding site. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating metastatic cancer, in particular bone metastatic cancer. More particularly, the present invention provides a means of therapeutically or prophylactically treating metastatic cancer by upregulating type I IFN levels.

Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: Methods, systems, and devices for distributed caching of encrypted encryption keys are described. Some multi-tenant database systems may support encryption of data records. To efficiently handle multiple encryption keys across multiple application servers, the database system may store the encryption keys in a distributed cache accessible by each of the application servers. To securely cache the encryption keys, the database system may encrypt (e.g., wrap) each data encryption key (DEK) using a second encryption key (e.g., a key encryption key (KEK)). The database system may store the DEKs and KEKs in separate caches to further protect the encryption keys. For example, while the encrypted DEKs may be stored in the distributed cache, the KEKs may be stored locally on application servers. The database system may further support “bring your own key” (BYOK) functionality, where a user may upload a tenant secret or tenant-specific encryption key to the database.

Abstract: The present invention relates generally to a method of detecting a risk of the progression of a pre-invasive neoplasia of the glandular epithelium. More particularly, the present invention provides a method of detecting a risk of the progression from a pre-invasive breast neoplasia by screening for the level of expression of Stefin A in the myoepithelial cells. The method of the present invention is useful in a range of applications including, but not limited to, assessing a neoplastic condition, monitoring the progression of such a condition, predicting the likelihood of a subject progressing to a more advance disease state or informing decisions in relation to the design of treatment schedules.

Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: The baseball/softball hitting training device includes a base, a frame body, and a ball suspension system. The ball suspension system is supported by the frame body. The frame body includes a vertical stem portion and an offset portion. An upwardly-projecting arm of the vertical stem and a downwardly-projecting arm of the offset portion define a vertical axis between them. The ball suspension system is supported between the upwardly-projecting arm and downwardly-projecting arm, with the ball held vertically intermedially via a tether in alignment with the vertical axis and positioned to allow the player to practice hitting. Height-adjustment mechanisms are also disclosed. The tethered-ball training device can optionally be converted to a tee-ball training device.

Abstract: The present invention relates generally to a method of prognosing the survival of a patient with a breast neoplasm, more particularly a patient with a breast neoplasm which is estrogen receptor-/progesterone receptor-/HER-2-(“triple-negative”). The method of the present invention more particularly provides a method for prognosing breast cancer patient survival, in particular risk of metastatic spread, by screening for IRF9 expression. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating patients with a triple-negative breast neoplasm, in particular those patients with triple-negative breast neoplasia which is characterised by a poor survival prognosis, still more particularly a high risk of metastatic spread, by upregulating type I IFN levels.

Abstract: Colloidal silver particles are incorporated into emulsions and other compositions that find use, for example, as pharmaceutical and dermatological serums, creams, lotions and ointments.

Abstract: A magneto-dielectric material operable between a minimum frequency and a maximum frequency, having: a plurality of layers that alternate between a dielectric material and a ferromagnetic material, lowermost and uppermost layers of the plurality of layers each being a dielectric material; each layer of the plurality of ferromagnetic material layers having a thickness equal to or greater than 1/15th a skin depth of the respective ferromagnetic material at the maximum frequency, and equal to or less than ?th the skin depth of the respective ferromagnetic material at the maximum frequency; each layer of the plurality of dielectric material layers having a thickness and a dielectric constant that provides a dielectric withstand voltage across the respective thickness of equal to or greater than 150 Volts peak and equal to or less than 1,500 Volts peak; and, the plurality of layers having an overall thickness equal to or less than one wavelength of the minimum frequency in the plurality of layers.

Abstract: Disclosed herein is a composite metamaterial comprising a polymer foam layer having one or both of a low dielectric constant of less than or equal to 2 and a low magnetic constant of less than or equal to 1, both determined at a frequency of 100 Hz and a temperature of 23° C.; wherein the polymer foam layer comprises a first surface, a second surface, and a plurality of vias that each independently at least partially extend from one or both of the first surface and the second surface into the polymer foam layer; and a via material having one or both of a high dielectric constant greater than the low dielectric constant and a high magnetic constant greater than the low magnetic constant disposed in and filling the plurality of vias.

Abstract: A wheelchair lifting system for transferring a wheelchair into and out of a vehicle includes a wheelchair that has a pair of rear wheels. A strap is provided and the strap may be manipulated. The strap is selectively extended through the spokes on each of the wheels. The strap engages the rim on each of the wheels to facilitate the wheelchair to be transferred into and out of a vehicle.

Abstract: The fitted sheet fits more easily around a mattress since it is fastened and cinched around the mattress. The fitted sheet includes a sheet with four sides and four corners with a cord fitted along each of the four sides of the sheet such that is can move. The cord is cinched with a tensioning mechanism which to applies tension to the cord. A zipper placed on one corner of the sheet is complete the fit.