Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: A pressure sensor includes a first plate (102), a second plate (104) and a foam (106) disposed between the first and second plate. The foam is a polyurethane foam having an average cell size of about 50 to 250 urn and a density of between 5 to 30 lbs/ft3.

Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: A gas turbine engine includes a combustor having a fuel nozzle assembly for delivering fuel to a combustion chamber. A sensor is at least partially housed within the fuel nozzle assembly for sensing a parameter associated with the delivery of fuel to the combustion chamber. In one example, the sensor is an optical sensor coupled to an optical decoder for ascertaining the parameter. A trim valve is in communication with the fuel nozzle assembly. A controller is in communication with the sensor and is programmed to actuate the trim valve to adjust the amount of fuel delivered through the fuel nozzle assembly in response to the parameter. In one example, an end of the optical sensor is arranged near a fuel exit of the fuel nozzle assembly. The controller actuates the trim valve for the fuel nozzle assembly to achieve a desired air/fuel ratio and/or balance the fuel delivery of the fuel nozzle assembly relative to another fuel nozzle assembly within the gas turbine engine's combustor system.

Abstract: A dielectric substrate comprises a resin composition impregnated with non-woven fibrous mat material having a thickness of 5 mils (127 micrometers), wherein the fibrous mat material comprises fibers, having a diameter of 1 nm to 10 ?m, that have been extruded through one or more openings to produce fibers that have been collected in the form of a fibrous non-woven mat, and wherein the fibers exhibit a multi-directional orientation in the non-woven mat material. The dielectric substrate is useful in circuit materials, circuits, and multi-layer circuits, economical to make, and has excellent electrical and mechanical properties.

Abstract: The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.

Abstract: A cooling arrangement for a turbine engine includes a cooling source and first and second structures. A ceramic-based composite cooling tube fluidly provides a fluid connection between the first and second structures. The cooling tube is configured to transfer a cooling fluid from the cooling source to the second structure.

Abstract: Examples of database systems, apparatus, methods and computer program products are disclosed for causing automated system events to be performed in response to environmental sensing. In some implementations, a database system can receive environmental data and location data from a computing device capable of reading environmental data using an environmental sensor. The sensor is situated at a geographic location identified by the location data. An occurrence of an environmental condition can be determined using the environmental data. A database record in a database can be created or updated to identify the environmental data and/or the environmental condition. A system event to perform can then be determined based on the creating or updating of the database record.

Abstract: The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterized by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.

Abstract: A system and method to optimize the yield of a restaurant having perishable inventory is described. Through a card company, a restaurant can market incentives to make reservations during an off-peak time to enrolled card members. Offer marketing is based on stated customer preferences, and conducted via, for example, a website, email, or text message. Reservations are made, for example, via a centralized booking service. The incentive is fulfilled to the card member in a coupon-less manner. The card company receives a commission from the participating restaurant for every such sale.

Abstract: The invention relates to a mechanism that can be integrated with silicon facial prostheses used to recapitulate a natural facial appearance through biomimetic actuation. The prosthetic eye comprises a servo motor, microcontroller, battery, rotational shaft, and customized stainless steel tarsus. The tarsus mimics the natural eyelid and reinforces the silicon lid for rotational blink motion. A stainless steel clip holds the device together and polyurethane foam encases the device to allow proper fitting in the orbital cavity. The present invention fits within a model orbital cavity and the generated blink motion is tunable to match the position profile of an in vivo blink.

Abstract: A dielectric substrate comprises a resin composition impregnated with non-woven fibrous mat material having a thickness of 5 mils (127 micrometers), wherein the fibrous mat material comprises fibers, having a diameter of 1 nm to 10 ?m, that have been extruded through one or more openings to produce fibers that have been collected in the form of a fibrous non-woven mat, and wherein the fibers exhibit a multi-directional orientation in the non-woven mat material. The dielectric substrate is useful in circuit materials, circuits, and multi-layer circuits, economical to make, and has excellent electrical and mechanical properties.

Abstract: The present invention relates generally to a method of diagnosing, prognosing or monitoring the development or progress of metastatic cancer, more particularly bone metastatic cancer. The method of the present invention more particularly provides a method for detecting metastatic cancer, or a predisposition thereto, by screening for the differential expression of a panel of genes which comprise an IRF7 binding site. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating metastatic cancer, in particular bone metastatic cancer. More particularly, the present invention provides a means of therapeutically or prophylactically treating metastatic cancer by upregulating type I IFN levels.

Abstract: Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the DDR2 gene. Further, a distinct subgroup of BRAF-mutated melanomas have somatic mutations in the DDR2 gene as well. Applications of this finding to routine diagnostics include the molecular stratification of melanoma, and the tissue identification of targetable DDR2 kinase mutations in routine formalin-fixed paraffin-embedded sections. Described herein are methods, compositions and kits related to the discovery that DDR2 mutations may be markers for melanoma generally, and BRAF-mediated melanoma in particular, opening up the possibility of dual therapy for melanoma by targeting both DDR2 and BRAF.

Abstract: The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterized by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.

Abstract: Recurring loan payments (e.g., mortgage payments) through a transaction card account is disclosed. Information is received at a transaction account system from a loan company system corresponding to an application received at the loan company system from a requester for a loan involving automatic debits to a transaction card account. A determination is made as to whether the requestor is eligible for the loan to be associated with a transaction card account. If not, the customer receives a communication of rejection. If eligible, a determination is made whether the transaction account system has stored therein a transaction card account of the requestor. If no, a transaction card account is opened for the requestor and associated with the loan. If yes, the loan payment is associated with the transaction card account bill.

Abstract: This invention relates to methods for the transformation of plants from the genus Allium, and transformed plants produced according to the method. Specifically, this invention relates to direct transformation of Allium leaf tissue using Agrobacterium mediated transformation, and plants regenerated from the transformed leaf tissue. In various aspects, the invention relates to a method of obtaining a transformed Allium leaf tissue and methods of obtaining a transformed Allium plant by regenerating the transformed leaf tissue.