Abstract: A method of configuring a blade of a drill bit includes determining a first desired depth of cut for a first radial swath associated with a bit face of a drill bit. The first radial swath is associated with a first area of the bit face. The method further includes identifying a first plurality of cutting elements located on the bit face. Each of the cutting elements includes at least a portion located within the first radial swath. The method additionally includes configuring a first blade surface of a blade. The first blade surface is located within the first radial swath and configured based on the first desired depth of cut for the first radial swath. The blade surface is also configured based on each portion of the first plurality of cutting elements located within the first radial swath.

Abstract: Teachings of the disclosure are directed to a reamer and/or bit interaction model system and method. The method may include receiving performance data regarding a cutting structure, and calculating a characteristic curve, using the performance data. The characteristic curve may be weight-based and/or torque-based. The method may also include storing the characteristic curve. In particular embodiments, the characteristic curve may include either weight on cutting structure or torque on the cutting structure, as a function of the rate of penetration.

Abstract: A method of configuring a depth of cut controller (DOCC) of a drill bit includes determining a first desired depth of cut for a first radial swath associated with a bit face of a drill bit. The first radial swath is associated with a first area of the bit face. The method further includes identifying a first plurality of cutting elements located on the bit face that each include at least a portion located within the first radial swath. The method additionally includes configuring a first depth of cut controller (DOCC) for placement on the bit face within the first radial swath. The first depth of cut controller is configured based on the first desired depth of cut for the first radial swath and each portion of the first plurality of cutting elements located within the first radial swath.

Abstract: A roller cone drill bit may include optimally designed bearing structures and cutting structures. The roller cone drill bit may include three cone assemblies rotatably mounted on respective spindles via respective bearing structures. Each cone assembly may have a respective cutting structure with a minimal moment center located along each respective axis of rotation. Each respective bearing structure has a center point located proximate each respective minimal moment center.

Abstract: In accordance with some embodiments of the present disclosure, a downhole drilling tool comprises a bit body, a blade on an exterior portion of the bit body, and a gage pad on the blade. The gage pad includes a ball retainer and a ball located in the ball retainer such that an exposed portion of the ball is positioned to contact a wellbore and rotate in response to frictional engagement with the wellbore.

Abstract: A multi-layer downhole drilling tool designed for drilling a wellbore including a plurality of formations is disclosed. The drilling tool includes a bit body and a plurality of primary blades and secondary blades with respective leading surfaces on exterior portions of the bit body. The drilling tool further includes a plurality of first layer cutting elements and second layer cutting elements located on the leading surfaces of the primary blades and secondary blades, respectively. Each second layer cutting element is under exposed with respect to the corresponding first layer cutting element. The amount of under-exposure is selected according to each second layer cutting element having an initial critical depth of cut greater than an actual depth of cut for a first drilling distance and a critical depth of cut equal to zero at a target drilling depth.

Abstract: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I): More particularly, it relates to said anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

Abstract: The present invention provides a compound, namely (+)-3?-Angeloyloxy-4?-keto-3?,4?-dihydroseselin (Pd-Ib) derived from Bupleurum malconense as the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.

Abstract: In accordance with some embodiments of the present disclosure, a method of configuring depth of cut controllers (DOCCs) of a drill bit comprises determining a primary depth of cut for a first radial swath. The first radial swath is associated with a first area of the bit face. The method further comprises configuring a primary DOCC for placement on the bit face within the first radial swath based on the primary depth of cut. In addition, the method comprises determining a back-up depth of cut for a second radial swath. The second radial swath is associated with a second area of the bit face that overlaps the first area of the bit face associated with the first radial swath. The method further comprises configuring a back-up DOCC for placement on the bit face within the second radial swath based on the back-up depth of cut.

Abstract: The present disclosure relates to an industrial device including a PCD element located in a recess of the industrial device. The PCD element and recess may contain an aligned mechanical lock. The device may also include a brazing material located along at least a portion of an interface between the PCD element and the recess. In a more specific embodiment, the industrial device may be an earth-boring drill bit, such as a fixed cutter drill bit, and the PCD element may be PCD cutter. In specific embodiments, the mechanical lock may include at least one ridge located at an end of the PCD element and in an end wall of the recess, at least one ridge located along a side of the PCD element and in a side wall of the recess, or at least an upper wall of the recess.

Abstract: There is provided an aqueous composite coating solution comprising a polymer matrix, a metal oxide immobilized onto an inorganic filler and optionally an additional UV absorber. The coating solution can be used to prepare barrier coatings shielding the substrate from UV radiation, moisture and oxygen. There is also provided a process for making such aqueous using titanium dioxide immobilized on clay in the composite materials. Protective layers obtained from coating using the composite polymer solutions are also provided.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity,

Abstract: Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.

Abstract: A method and apparatus for determining the effectiveness of bearing seals in s roller cone drill bit. The bit includes a sensor in optical communication with the bearing lubricant. The sensor includes a light source, an optical filter, and an optical detector arranged so that light interacts with the lubricant, is filtered, and detected, wherein the detected light is indicative of the amount of contaminant within the lubricant. The optical filter is preferably an integrated computing element that filters preselected orthogonal components from the light.

Abstract: There is provided a conductive fibrous material comprising a plurality of carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The carbonaceous fibers may be fused at fiber-to-fiber contact points by a polymer. The process of making the conductive fibrous material comprises mixing a phenolic polymer with a second polymer to form a polymer solution, preparing phenolic fibers having nano- or micro-scale diameters by electrospinning the polymer solution, and subsequent carbonization of the obtained phenolic fibers, thereby generating carbonaceous fibers, wherein each carbonaceous fiber is fused to at least one other fiber. The conductive fibrous material may be useful in electrode materials for energy storage devices.

Abstract: A rotary drill bit with cutting elements operable to control depth of cut and rate of penetration during formation of a wellbore are provided. Respective sets of secondary cutting elements and primary cutting elements may also be disposed on exterior portions of a rotary drill bit. A number of blades may extend from exterior portions of the drill bit with a number of cutting elements disposed on exterior portions of each blade. Each cutting element may include a substrate with a cutting surface disposed thereon. A respective protector may extend from the cutting surface of one or more cutting elements to limit depth of penetration of the associated cutting element into adjacent portions of a downhole formation and/or to control rate of penetration of an associated rotary drill bit.

Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.

Abstract: A method of preparing a fiber-reinforced polymer composite is provided. The method includes (a) providing a swollen clay material; (b) chemically modifying a surface of the swollen clay material with an organosilane to form a silane-modified clay material; (c) intercalating the silane-modified clay material with a binder to form an intercalated clay material; and (d) melt compounding the intercalated clay material with a mixture comprising a polymer and fiber to form the fiber-reinforced polymer composite. A fiber-reinforced polymer composite is also provided.

Abstract: The present invention provides a compound, namely (+)-3?-Angeloyloxy-4?-keto-3?, 4?-dihydroseselin (Pd-Ib) derived from Bupleurum malconense as the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.

Abstract: Downhole drilling tools designed and manufactured to minimize or reduce imbalance forces and wear by disposing cutting elements in cutter groups and cutter sets in a level of force balance and by placing impact and/or wear resistant cutters on blades subject to high impact forces and/or large loadings. Manufacturing costs may be reduced by placing inexpensive cutters on blades not subject to high impact forces and/or loadings. Some embodiments comprise designing downhole tools with combinations of thicker blades to receive high impact forces and/or loadings with thinner blades. Some embodiments comprise designing downhole drilling tools with optimized fluid-flow properties. Designing methods may comprise performing simulations on a designed tool, evaluating respective forces acting on cutters during simulated engagement with a downhole (uniform and transitional) and/or evaluating wear on cutters and bit, and/or CFD simulations to evaluate fluid-flow optimization on a tool.