Abstract: The present disclosure relates to a method of forming a metallic layer having pores extending therethrough, the method comprising the steps of: (a) contacting a cathode substrate with an electrolyte solution comprising at least one cation; reducing the cation to deposit the metallic layer on a surface of the cathode substrate; and (c) generating a plurality of non-conductive regions on the cathode substrate surface during reducing step (b); wherein the deposition of the metallic layer is substantially prevented on the non-conductive regions on the cathode substrate surface to thereby form pores extending through the deposited metallic layer. The present disclosure further provides a metallic porous membrane fabricated by the disclosed process.

Abstract: In one embodiment, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation at an opto-analytical device coupled to the drilling tool. The method also includes determining a drilling characteristic based on the received electromagnetic radiation, and detecting an event associated with drilling the wellbore based on the determined drilling characteristic.

Abstract: In one embodiments, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation using an opto-analytical device coupled to the drilling tool. The method also includes detecting a characteristic of cuttings associated with drilling the wellbore based on the received electromagnetic radiation.

Abstract: In one embodiment, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation using an opto-analytical device coupled to the drilling tool. The method also includes detecting a temperature associated with drilling the wellbore based on the received electromagnetic radiation.

Abstract: Disclosed are improved cutters for fixed-cutter rotating drill bits. One cutter includes a substrate defining a slot therein and being configured to be coupled to a middle portion of a blade of the drill bit, and a cutting element secured within the slot and having at least a portion of the cutting element extending out of the slot, the cutting element further having a first face and a second face, wherein portions of the first and second faces are supported by the substrate within the slot.

Abstract: In one embodiment, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation using an opto-analytical device coupled to the drilling tool. The method also includes detecting vibrations associated with drilling the wellbore based on the received electromagnetic radiation.

Abstract: In one embodiments, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation using an opto-analytical device 1000 coupled to the drilling tool. The method also includes determining torsion associated with drilling the wellbore based on the received electromagnetic radiation.

Abstract: Downhole drilling tools designed and manufactured to minimize or reduce imbalance forces and wear by disposing cutting elements in cutter groups and cutter sets in a level of force balance and by placing impact and/or wear resistant cutters on blades subject to high impact forces and/or large loadings. Manufacturing costs may be reduced by placing inexpensive cutters on blades not subject to high impact forces and/or loadings. Some embodiments comprise designing downhole tools with combinations of thicker blades to receive high impact forces and/or loadings with thinner blades. Some embodiments comprise designing downhole drilling tools with optimized fluid-flow properties. Designing methods may comprise performing simulations on a designed tool, evaluating respective forces acting on cutters during simulated engagement with a downhole (uniform and transitional) and/or evaluating wear on cutters and bit, and/or CFD simulations to evaluate fluid-flow optimization on a tool.

Abstract: The present invention provides composition for treating cancer comprising polyprenylated acylphloroglucinol (PPAP) compound. The present invention also provides a composition comprising Guttiferone K for treating esophageal cancer and liver cancer. The present invention further provides a method of using said compound for inhibiting cancer metastasis.

Abstract: In one embodiment, a downhole drilling tool configured to engage a formation to form a wellbore includes one or more channels formed in a bit body, the channels configured to direct electromagnetic radiation. The downhole drilling tool also includes an opto-analytical device integrated with the downhole drilling tool, the opto-analytical device configured to receive electromagnetic radiation directed through the one or more channels and detect a drilling characteristic based on the received electromagnetic radiation.

Abstract: In one embodiment, a method includes drilling a wellbore in a formation with a drilling tool. The method further includes receiving electromagnetic radiation using an opto-analytical device coupled to the drilling tool. The method also includes determining a distance between a portion of the drilling tool and the formation based on the received electromagnetic radiation.

Abstract: Teachings of the disclosure are directed to a reamer and/or bit interaction model system and method. The method may include receiving performance data regarding a cutting structure, and calculating a characteristic curve, using the performance data. The characteristic curve may be weight-based and/or torque-based. The method may also include storing the characteristic curve. In particular embodiments, the characteristic curve may include either weight on cutting structure or torque on the cutting structure, as a function of the rate of penetration.

Abstract: A drill bit using track-set depth of cut control elements to provide improved stability is disclosed. A drill bit for drilling a wellbore includes a bit body with a rotational axis extending therethrough. The drill bit further includes a plurality of blades disposed on exterior portions of the bit body. The drill bit includes a first group of track set depth of cut controllers (DOCCs) disposed on exterior portions of a first set of the plurality of blades. The first group of track set DOCCs configured to be placed within a first radial swath of a bit face of the drill bit and configured to provide a first critical depth of cut (CDOC).

Abstract: According to some embodiments of the present disclosure, a method for configuring a drill bit comprises determining a number of blades of a drill bit. If the number of blades of the drill bit equals five, the method further comprises disposing each of a plurality of depth of cut controllers (DOCCs) on one of the blades of the drill bit such that each group of three radially consecutive DOCCs of the plurality of DOCCs is substantially force balanced. If the number of blades of the drill bit is greater than five, the method further comprises disposing each of the plurality of DOCCs on one of the blades of the drill bit such that each group of four radially consecutive DOCCs of the plurality of DOCCs is substantially force balanced.

Abstract: A multi-layer downhole drilling tool designed for drilling a wellbore including a plurality of formations is disclosed. The drilling tool includes a bit body including a rotational axis extending therethrough. A plurality of blades are disposed on exterior portions of the bit body. A plurality of primary cutting elements and a plurality of back-up cutting elements are disposed on exterior portions of the plurality of blades. The back-up cutting elements are track set with corresponding primary cutting elements, and each back-up cutting element is disposed on a different blade than the corresponding primary cutting element.

Abstract: A multi-layer downhole drilling tool designed for directional and horizontal drilling is disclosed. The drilling tool includes a bit body including a rotational axis extending therethrough. A plurality of primary blades are disposed on exterior portions of the bit body and a plurality of secondary blades are disposed on exterior portions of the bit body between the primary blades. The drilling tool further includes a plurality of first-layer cutting elements disposed on exterior portions of the primary blades and a plurality of second-layer cutting elements disposed on exterior portions of the secondary blades. The second-layer cutting elements are track set with the first-layer cutting elements in an opposite track set configuration.

Abstract: Various downhole drilling tools designed and manufactured at least in part on evaluating respective forces acting on respective groups and sets of cutting elements during simulated engagement with the downhole end of a wellbore and drilling from a first downhole formation into a second downhole formation. Simulating forces acting on each cutting element as the cutting element contacts a downhole formation may be used to force balance downhole drilling tools during transition drilling or non-uniform downhole drilling conditions. Multilevel force balanced downhole drilling tools may be designed using five respective simulations, cutter group level, neighbor cutter group level, cutter set level, group of N (N=3 or N=4) consecutive cutters level and all cutters level. Various cutter layout procedures and algorithms may also be used to design multilevel force balanced downhole drilling tools which may drill faster with higher lateral stability, especially during downhole transiting drilling conditions.

Abstract: Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.

Abstract: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound. More particularly, it relates to an anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

Abstract: This invention is related to compounds isolated from various Garcinia species and method of treating cancer. The present invention provides composition for treating cancer comprising polyprenylated acylphloroglucinol (PPAP) compound. The present invention also provides a composition comprising Guttiferone K for treating esophageal cancer.