Patents by Inventor Shinya Ishii

Shinya Ishii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11371039
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: June 28, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Takashi Nakai
  • Patent number: 11365469
    Abstract: Provided is a hot-dip aluminized steel sheet with fine-sized spangles produced in a different way from conventional methods, and a method of producing a hot-dip aluminized steel sheet with fine-sized spangles in a different way from conventional methods. The hot-dip aluminized steel sheet includes: a substrate steel sheet; and an aluminum-based coating which is formed by a hot-dip method on the surface of the substrate steel sheet and in which the average B concentration is not less than 0.005 mass % and the sum of the average Ti concentration and the average V concentration is not more than 0.03 mass %.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: June 21, 2022
    Assignees: NIPPON STEEL NISSHIN CO., LTD., NS Wheeling-Nisshin, Inc.
    Inventors: Koutarou Ishii, Shinya Furukawa, Shinichi Koga, Yasunori Hattori, Tetsuhiko Okano, Patrick Edward Pendleton
  • Publication number: 20220187308
    Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 16, 2022
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki IGAWA, Shinya ISHII, Miho FUNAKI, Naoka HIRONIWA, Shun SHIMIZU
  • Patent number: 11359194
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: June 14, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Takashi Nakai
  • Publication number: 20220154741
    Abstract: There is provided a work machine that can limit operation of a work device by MC, and improves the responsiveness of a hydraulic actuator to operation of an operation device by an operator, and ensures operability equivalent to that of a work machine that does not have MC functions, and allows the hydraulic actuator for which the operation device is not being operated to automatically operate in either direction of the operation directions thereof. For this purpose, a drive system includes a selector valve 203a disposed between a secondary port 134a of an operation device 45a and a flow control valve 15a and between a proportional solenoid valve 54a and the flow control valve 15a and a selector valve 203b disposed between a secondary port 134b of the operation device 45a and the flow control valve 15a and between a proportional solenoid valve 54b and the flow control valve 15a.
    Type: Application
    Filed: May 20, 2020
    Publication date: May 19, 2022
    Inventors: Hiroki ISHII, Shinjiro YAMAMOTO, Masamichi ITOU, Yasutaka TSURUGA, Shinya IMURA
  • Publication number: 20220041741
    Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Mika Sakurai, Tetsuo Kojima, Tatsuhiko Tachibana, Hirotake Shiraiwa, Hiroyuki Tsunoda, Yoshinobu Higuchi
  • Patent number: 11243210
    Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: February 8, 2022
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Miho Funaki, Naoka Hironiwa, Shun Shimizu
  • Publication number: 20210289126
    Abstract: An image capture apparatus performs control such that when an approaching to a finder is not made, a touch operation with an area that is less than a first threshold on the touch operation surface is validated, and a touch operation with an area that is not less than the first threshold on the touch operation surface is invalidated, when the approaching to the finder is made, the touch operation with the area that is not less than the first threshold on the touch operation surface is validated even if the touch operation has the area that is not less than the first threshold on the touch operation surface.
    Type: Application
    Filed: March 9, 2021
    Publication date: September 16, 2021
    Inventor: Shinya Ishii
  • Patent number: 11022839
    Abstract: A display apparatus according to the present invention, includes: a light-emitting unit of which light emission brightness is controllable; a display panel configured to transmit light from the light-emitting unit and display an image; an operation unit configured to receive an operation for instructing a mode to be set, out of a plurality of modes including a first mode in which a first image including an input image and not including a graphic image is displayed and a second mode in which a second image including the input image and the graphic image is displayed; and a control unit configured to perform brightness control for controlling the light emission brightness of the light-emitting unit so that an upper-limit display brightness in the second mode is lower than an upper-limit display brightness in the first mode.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: June 1, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventor: Shinya Ishii
  • Publication number: 20210079379
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki IGAWA, Shinya ISHII, Atsuhiko MAEDA, Takashi NAKAI
  • Publication number: 20210079378
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki IGAWA, Shinya ISHII, Atsuhiko MAEDA, Takashi NAKAI
  • Patent number: 10741131
    Abstract: A display apparatus according to the present invention, includes: a display unit configured to display an image based on display image data generated from input image data; a control unit configured to control emission brightness of a light source of the display unit; and a detecting unit configured to detect a user operation for specifying a position in the image, wherein the control unit controls the emission brightness of the light source of the display unit in accordance with a gradation value of the input image data corresponding to the position specified by the user operation, to emission brightness that is lower than set emission brightness or to emission brightness that is higher than the set emission brightness.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: August 11, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Shinya Ishii, Joji Kamahara
  • Publication number: 20200231688
    Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
    Type: Application
    Filed: April 2, 2020
    Publication date: July 23, 2020
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Mika Sakurai, Tetsuo Kojima, Tatsuhiko Tachibana, Hirotake Shiraiwa, Hiroyuki Tsunoda, Yoshinobu Higuchi
  • Patent number: 10719922
    Abstract: An image processing apparatus includes a setting unit configured to set at least one of a plurality of display modes including a first display mode and a second display mode, and a processing unit configured to perform first gradation conversion processing on input image data when the first display mode is set, and to perform second gradation conversion processing on the input image data when the second display mode is set, wherein the second gradation conversion processing improves a gradation of a part of a gradation range of the input image data to a further extent than the first gradation conversion processing. Upon reception of an instruction for displaying an enlarged image of a part of an image region of the input image data in a state where the first display mode is set, the first display mode is canceled and the second display mode is set.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: July 21, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventor: Shinya Ishii
  • Patent number: 10662245
    Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: May 26, 2020
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Mika Sakurai, Tetsuo Kojima, Tatsuhiko Tachibana, Hirotake Shiraiwa, Hiroyuki Tsunoda, Yoshinobu Higuchi
  • Patent number: 10578455
    Abstract: A device for providing electric-moving-body information is provided with a calculation unit for calculating, upon receiving a departure point and state of charge (SOC) of an electric vehicle, a plurality of reachable points capable of being reached if an electric vehicle departs from a destination after reaching the destination from the departure point and a display data generation unit for generating display data for displaying a reachable range display screen that makes it possible to visually recognize the plurality of reachable points. Information that is more useful for determining actions that can be taken after arriving at a destination is provided to an electric-moving-body user.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 3, 2020
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Tetsuya Adachi, Shinya Ishii, Nobuyuki Owari, Hidekazu Ono, Hiroyuki Kozawa
  • Publication number: 20200048627
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Application
    Filed: March 22, 2019
    Publication date: February 13, 2020
    Inventors: Tomoyuki IGAWA, Shinya ISHII, Atsuhiko MAEDA, Takashi NAKAI
  • Patent number: 10501737
    Abstract: The present invention provides a method for preparing a bacteriophage displaying an antigen-binding molecule, comprising the step of contacting a helper phage capable of expressing a first polypeptide with a bacterium capable of expressing a second polypeptide, wherein the first polypeptide and the second polypeptide associate with each other to form the antigen-binding molecule.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: December 10, 2019
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventor: Shinya Ishii
  • Patent number: 10472623
    Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: November 12, 2019
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Atsuhiko Maeda, Takashi Nakai
  • Publication number: 20190086725
    Abstract: A display apparatus according to the present invention, includes: a light-emitting unit of which light emission brightness is controllable; a display panel configured to transmit light from the light-emitting unit and display an image; an operation unit configured to receive an operation for instructing a mode to be set, out of a plurality of modes including a first mode in which a first image including an input image and not including a graphic image is displayed and a second mode in which a second image including the input image and the graphic image is displayed; and a control unit configured to perform brightness control for controlling the light emission brightness of the light-emitting unit so that an upper-limit display brightness in the second mode is lower than an upper-limit display brightness in the first mode.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 21, 2019
    Inventor: Shinya Ishii