Abstract: A directed-energy irradiating apparatus invention includes a switch which selects one of an FEL apparatus and an HPM apparatus to be supplied with microwave based on external environmental data. A target is destroyed even in a situation that a destruction effect by a FEL beam cannot be expected, while maintaining the destruction ability for the target by the FEL beam.

Abstract: A directed-energy irradiating apparatus includes an FEL apparatus 20 and an HPM apparatus 30. The FEL apparatus 20 accelerates free electrons by using microwave supplied from a microwave source to irradiate an FEL beam and outputs remaining microwave. The HPM apparatus irradiates an HPM beam generated based on the remaining microwave outputted from the FEL apparatus. It is possible to destroy a target even in a situation that a destruction effect by the FEL beam cannot expected, while maintaining the destruction ability of the FEL beam.

Abstract: An X-ray generating device (10) is provided with an electron gun (12) that generates an electron beam, a linear accelerator (14) that accelerates, by means of microwaves, the electron beam generated by the electron gun (12), an X-ray target (16) that generates X-rays by being irradiated with the electron beam accelerated by the linear accelerator (14), a microwave generating device that generates microwaves to be introduced into the linear accelerator (14), and a pulse modulator that controls the microwave generating device so as to change the power of the microwaves. Because the linear accelerator (14) includes a plurality of buncher cavities (40), even if there are electrons that are shifted out of the acceleration phase when the power of the microwaves is decreased, these electrons can be accelerated in the acceleration phase of the next time period; therefore, a decrease in the intensity of an electron beam to be emitted is suppressed even if the power of the microwaves is decreased.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: A display unit is controlled to increase luminance of a white pixel of a display apparatus in a case where an image capturing apparatus is in an image capturing mode as compared with a case where the image capturing apparatus is in a reproduction mode.

Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

Abstract: A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

Abstract: A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

Abstract: A content sharing system and content importance level judging method are provided. The content sharing system provides an importance level of arbitrary content is individually judged with respect to users and a notice message valuable for a user is appropriately notified to a client or the outside tool. Further, an access user is able to set the disclosure level of access record of a user accessed the content. In the content sharing system, an importance level of content of multimedia data on a server shared with clients of a plurality of users is judged, in which the importance level of the content with respect to each user is individually calculated by interpreting existing data or a user environment, the client condition is judged, a notice rule setting is changed in accordance with the client condition or an instruction from the client, and a notice message is issued to an appropriate address based on the calculated importance level and a notice rule of the content.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: A method for converting frames that can display smooth moving images is provided. A memory (16) to which image data of frames in the NTSC format is written is provided. A memory controller (14) for retrieving image data of an odd field and an even field from the memory (16) every odd field period and even field period in the frame period of the PAL format is provided. An interpolating circuit (76) is provided. The interpolating circuit (76) mixes the image data of the odd field retrieved by the memory controller (14) and image data of a next odd field at a predetermined ratio to output as image data of an odd field in the frame period of the PAL format, and mixes the retrieved image data of the even field and image data of a next even field at a predetermined ratio to output as image data of an even field in the frame period of the PAL format. A coefficient-generating circuit (73) for changing the mixing ratios in the interpolating circuit (76) every field period of the PAL format is provided.

Abstract: Disclosed herein is a display control apparatus which may include an image conversion unit, a display unit, a point specifying unit, and a visual-point position setting unit.

Abstract: An optically pumped disk type solid state laser oscillator includes: a cylindrical shape thin film laser gain medium having a through-hole; a ring mirror whose surface is opposing to a side surface of the thin film laser gain medium; a conical mirror arranged in the through-hole and reflects a light from the ring mirror to a direction perpendicular to the thin film laser gain medium where an output mirror is arranged. The ring mirror, the conical mirror and the output mirror compose a resonator for oscillating a laser beam to be outputted from the output mirror.

Abstract: An information processing apparatus is provided which allows a user to easily and intuitively manipulate information in a 3-dimensional virtual space. In the information processing apparatus, a main controller sets a first coordinate system in a real space on the basis of information associated with a real object and further sets a second coordinate system in a 3-dimensional virtual space corresponding to the real space on the basis of the first coordinate system. If a user places an input device at a particular position and angle in the first coordinate system with reference to the real object, the main controller places an object in the 3-dimensional virtual space at a place and angle in the second coordinate system corresponding to the place and angle of the input device in the first coordinate system, and the main controller displays an image of the object placed in the 3-dimensional virtual space on a display.