Abstract: A display apparatus according to the present invention, includes: a light-emitting unit of which light emission brightness is controllable; a display panel configured to transmit light from the light-emitting unit and display an image; an operation unit configured to receive an operation for instructing a mode to be set, out of a plurality of modes including a first mode in which a first image including an input image and not including a graphic image is displayed and a second mode in which a second image including the input image and the graphic image is displayed; and a control unit configured to perform brightness control for controlling the light emission brightness of the light-emitting unit so that an upper-limit display brightness in the second mode is lower than an upper-limit display brightness in the first mode.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: A display apparatus according to the present invention, includes: a display unit configured to display an image based on display image data generated from input image data; a control unit configured to control emission brightness of a light source of the display unit; and a detecting unit configured to detect a user operation for specifying a position in the image, wherein the control unit controls the emission brightness of the light source of the display unit in accordance with a gradation value of the input image data corresponding to the position specified by the user operation, to emission brightness that is lower than set emission brightness or to emission brightness that is higher than the set emission brightness.

Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: An image processing apparatus includes a setting unit configured to set at least one of a plurality of display modes including a first display mode and a second display mode, and a processing unit configured to perform first gradation conversion processing on input image data when the first display mode is set, and to perform second gradation conversion processing on the input image data when the second display mode is set, wherein the second gradation conversion processing improves a gradation of a part of a gradation range of the input image data to a further extent than the first gradation conversion processing. Upon reception of an instruction for displaying an enlarged image of a part of an image region of the input image data in a state where the first display mode is set, the first display mode is canceled and the second display mode is set.

Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: A device for providing electric-moving-body information is provided with a calculation unit for calculating, upon receiving a departure point and state of charge (SOC) of an electric vehicle, a plurality of reachable points capable of being reached if an electric vehicle departs from a destination after reaching the destination from the departure point and a display data generation unit for generating display data for displaying a reachable range display screen that makes it possible to visually recognize the plurality of reachable points. Information that is more useful for determining actions that can be taken after arriving at a destination is provided to an electric-moving-body user.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: The present invention provides a method for preparing a bacteriophage displaying an antigen-binding molecule, comprising the step of contacting a helper phage capable of expressing a first polypeptide with a bacterium capable of expressing a second polypeptide, wherein the first polypeptide and the second polypeptide associate with each other to form the antigen-binding molecule.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: A display apparatus according to the present invention, includes: a light-emitting unit of which light emission brightness is controllable; a display panel configured to transmit light from the light-emitting unit and display an image; an operation unit configured to receive an operation for instructing a mode to be set, out of a plurality of modes including a first mode in which a first image including an input image and not including a graphic image is displayed and a second mode in which a second image including the input image and the graphic image is displayed; and a control unit configured to perform brightness control for controlling the light emission brightness of the light-emitting unit so that an upper-limit display brightness in the second mode is lower than an upper-limit display brightness in the first mode.

Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.

Abstract: A device for providing electric-moving-body information is provided with a calculation unit for calculating, upon receiving a departure point and state of charge (SOC) of an electric vehicle, a plurality of reachable points capable of being reached if an electric vehicle departs from a destination after reaching the destination from the departure point and a display data generation unit for generating display data for displaying a reachable range display screen that makes it possible to visually recognize the plurality of reachable points. Information that is more useful for determining actions that can be taken after arriving at a destination is provided to an electric-moving-body user.

Abstract: A display apparatus according to the present invention, includes: a display unit configured to display an image based on display image data generated from input image data; a control unit configured to control emission brightness of a light source of the display unit; and a detecting unit configured to detect a user operation for specifying a position in the image, wherein the control unit controls the emission brightness of the light source of the display unit in accordance with a gradation value of the input image data corresponding to the position specified by the user operation, to emission brightness that is lower than set emission brightness or to emission brightness that is higher than the set emission brightness.

Abstract: The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

Abstract: A display unit is controlled to increase luminance of a white pixel of a display apparatus in a case where an image capturing apparatus is in an image capturing mode as compared with a case where the image capturing apparatus is in a reproduction mode.

Abstract: Disclosed is a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each other, wherein an antigen-binding domain in each of the antigen-binding molecules comprises at least one amino acid residue that changes the antigen-binding activity of the antigen-binding molecule depending on ion concentration conditions. Also disclosed are a composition comprising a plurality of polynucleotide molecules each encoding the antigen-binding molecules, a composition comprising a plurality of vectors each comprising the polynucleotide molecules, a method for selecting the antigen-binding molecules, a method for isolating the polynucleotide molecules, a method for producing the antigen-binding molecules, and a pharmaceutical composition comprising any of the antigen-binding molecules.

Abstract: An image processing apparatus includes a setting unit configured to set at least one of a plurality of display modes including a first display mode and a second display mode, and a processing unit configured to perform first gradation conversion processing on input image data when the first display mode is set, and to perform second gradation conversion processing on the input image data when the second display mode is set, wherein the second gradation conversion processing improves a gradation of a part of a gradation range of the input image data to a further extent than the first gradation conversion processing. Upon reception of an instruction for displaying an enlarged image of a part of an image region of the input image data in a state where the first display mode is set, the first display mode is canceled and the second display mode is set.