Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: A device and system for non-invasively measuring wavelength-dependent changes in optical absorption of brain tissue damaged by CTE, TBI, concussion, repetitive trauma, and/or Lou Gehrig's disease in comparison to signals from healthy normal tissue for a subject in vivo. The brain, tissues, and fluids superficial to the brain are trans-cranially illuminated by light source(s) in low-absorption spectral windows for tissue in the visible and/or near-infrared parts of the spectrum. Optode(s) are disposed at predetermined radial distance(s) from a light output to collect the scattered and/or deflected signal from the surface of the head. The predetermined radial distance from the light output to the optode is correlated with the depth of tissue penetration for the light collected by the optode. A spectrometer and computer analyze the collected light for characteristic optical signatures of the brain tissue damage utilizing the absorbance and/or reflectance and/or transmission spectra generated as a result.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: Methods and apparatus for making autonomous vehicle handover decisions are described. A handover decision involves deciding if an autonomous vehicle should be handed off from one worker to another worker. The methods allow for decisions to be made in real or near real time shortly before an autonomous vehicle changes location. Worker time, if a handover is not implemented, is considered including the amount of worker time involved with the worker moving with the autonomous vehicle to the new location as compared to a new worker meeting the autonomous vehicle at the new location or on the way to the new location. Handover decisions can consider worker distribution and/or order priority. Such factors can be used to weight one or more time based cost values with a cost value representation of the cost if a handover is not implemented vs implementing a handover being compared to make the handover decision.

Abstract: Methods and systems are described herein for determining data shifts using change point detection in time series datasets. The system receives, from a change point modelling system, a first model and a plurality of change points detected within a time series dataset using the first model. The system generates, for each change point, a second corresponding model that fails to detect a corresponding change point and inputs the time series dataset into the first model and into each second corresponding model. The system determines a performance difference between the first model and each second corresponding model and assigns severity metrics to the change points based on the corresponding performance difference. The system selects a subset of change points based on the severity metrics and determines a cause of each change point of the subset of change points.

Abstract: A multi-junction photovoltaic device comprising a layer of metal oxynitride between a first sub-cell and a second sub-cell is disclosed, the first sub-cell having a layer comprising a perovskite light absorber material. In addition, a method of manufacturing said multi junction photovoltaic device is disclosed. The metal oxynitride is preferably titanium oxynitride. Advantageously, the device may be produced in a simple, fast, consistent and inexpensive manner, whilst the properties of the titanium oxynitride layer may be tuned to avoid the occurrence of local shunt paths and to reduce reflection losses.

Abstract: A system that is configured to receive a sequence of task inputs and to perform a machine learning task is described. An RL neural network is configured to: generate, for each task input of the sequence, a respective decision that determines whether to encode the task input or to skip the task input, and provide the respective decision of each task input to the task neural network. The task neural network is configured to: receive the sequence of task inputs, receive, from the RL neural network, for each task input of the sequence, a respective decision, process each of the un-skipped task inputs in the sequence of task inputs to generate a respective accumulated feature for the un-skipped task input, and generate a machine learning task output for the machine learning task based on the last accumulated feature generated for the last un-skipped task input in the sequence.

Abstract: Disclosed are conjugates and methods of identifying ligands for substrates using said conjugates. Also disclosed herein are methods of making the conjugates.

Abstract: An apparatus and process for the activation of catalyst material utilized in ammonia cracking can include an initial use of hydrogen and heat to perform an initial stage of catalyst activation and a subsequent use of ammonia and heat to perform a subsequent state of catalyst activation. The subsequent use of ammonia can be configured so that different catalytic material at different plant elements are activated in a pre-selected sequence to provide activation of the catalytic material utilized in different plant elements. Some embodiments can be configured to avoid excess temperatures that can be detrimental to equipment that can be positioned upstream of a furnace in some embodiments while also avoiding sintering of the catalytic material.

Abstract: In some aspects, a non-transitory computer readable medium is disclosed that has an application stored thereon that when executed by a processor of an electronic device causes the processor to perform a process. The process can include receiving motion data from a motion sensor, the motion data being indicative of motion by a user while wearing the motion sensor. The process can also include transmitting the motion data to a server, receiving from the server a time that the motion data indicates a foot of the user experienced a loading force which risked adversely impacting an existing foot ulcer or causing a new foot ulcer, determining a geographic location of the motion sensor at the time that the foot experienced the loading force, displaying the time and the geographic location, and requesting that the user identify an activity engaged in by the user at the time and the geographic location.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: A transistor stack can include a combination of floating and body tied devices. Improved performance of the RF amplifier can be obtained by using a single body tied device as the input transistor of the stack, or as the output transistor of the stack, while other transistors of the stack are floating transistors. Transient response of the RF amplifier can be improved by using all body tied devices in the stack.

Abstract: A half-bridge driver circuit periodically repeats switching cycles by closing a first FET via a first drive signal, detecting an instant when a current flowing through the first FET reaches a threshold and then opening the first FET and closing a second FET via a second drive signal. An error amplifier generates a control voltage by comparing a feedback signal with a reference signal, and a variable current generator generates a first current as a function of the control voltage. The error amplifier includes a proportional-integral controller, and a slope compensation circuit that generates a second current as a ramp signal. The threshold is generated by subtracting the second current from the first current. In response to detecting the instant, the second current is sampled and a signal indicative of the threshold is generated by subtracting the sampled second current from the first current.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: Fusion polypeptides are disclosed which are substrates for Kutzneria albida transglutaminase. The fusion polypeptides comprise one or more FKBP chaperone(s) and a target polypeptide. Each of these elements is separated from the neighboring element by a linker amino acid sequence. It was found that inserting glutamic acid containing transglutaminase recognition motifs into the linker amino acid chains is advantageous. Subsequent labeling reactions catalyzed by the transglutaminase surprisingly provide labeled fusion polypeptides have superior properties when compared with chemically random-labeled fusion polypeptides of similar design. Assays and kits are provided for in vitro detection of target antibodies in samples.

Abstract: A method for determining a measurement setting for measuring a parameter of interest from a target structure on a substrate. The method includes: obtaining first position difference data describing a difference between a position of a first representative target structure position and a position of one or more first features relating to product structure; obtaining optical metrology data relating to optical measurements of the target structure and further relating to a plurality of different measurement settings; and determining the measurement setting from the first position difference data and the optical metrology data such that a measured feature position value obtained from an optical measurement of the target structure using the determined measurement setting is better correlated to a position of the one or more first features.

Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.

Abstract: Systems and methods for importing documents are described. An input image is received and preprocessed. OCR and/or page segmentation and chapter detection are performed. Special-case processing is performed for lists, tables, free text, and other categories. Anaphora analysis, stemming, lemmatization, and relationship detection are performed. A genealogical tree is generated, augmented, or merged based on the extracted entities and relationships.

Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus includes a first interface and a second interface. The first interface is configured to obtain a control message. The control message instructs the first apparatus to transmit a first data frame concurrently with a second data frame from a second apparatus in a first mode. Alternatively, the control message instructs the first apparatus to transmit the first data frame at a different time than the second data frame from the second apparatus in a second mode. The second interface is configured to output the first data frame for transmission concurrently with the second data frame in the first mode, or at the different time than the second data frame in the second mode, according to the control message.

Abstract: With the present inventive concept there is provided a system comprising: a test card receiver configured to receive a test card, wherein the test card comprises a sample portion having a first side and a second side opposite the first side, wherein the sample portion of the test card is configured to hold a sample for PCR; a temperature adjuster configured to adjust a temperature of the sample portion of the test card over a plurality of temperature cycles, wherein each temperature cycle is between a first temperature and a second temperature different than the first temperature, wherein the temperature adjuster comprises a surface configured to be in contact with the first side of the sample portion of the test card; wherein the test card receiver comprises a spring member configured to push the sample portion of the test card towards the surface of the temperature adjuster; and a monitoring arrangement configured to monitor the sample portion of the test card over the plurality of temperature cycles, the m