Abstract: The channel estimation technique employs a set of pilot tones to determine channel state information. Because some of the pilot tones contained in the OFDM symbols may be missing after transmission, the disclosed technique employs a set of known pilot tones to compute an estimate of the channel impulse response, which may exhibit a level of distortion. Non-zero terms of the estimated channel impulse response that fall outside of a prescribed time window are regarded as artifacts of a set of missing or unknown pilot tones. Information relating to the known pilot tones and the artifacts of the unknown pilot tones are employed for mathematically reconstructing and deriving values of the unknown tones. Then, the values of the known pilot tones and the derived values of the unknown pilot tones are employed to recompute the channel impulse response, thereby obtaining the channel estimate with a reduced level of distortion.

Abstract: An integrated filler system to transfer a filler product from a filler product source to a product receptacle is provided. The integrated filler system includes a cylinder housing, a pallet valve disposed within the cylinder housing that contains a product flow aperture, and a piston inserted in a valve bore of the pallet valve. A linear actuator is connected to the piston to selectively actuate a linear travel of the piston within the valve bore. A rotary actuator is connected to the pallet valve to selectively position the product flow aperture to fluidly communicate with either a product input port or a product output port formed in the cylinder housing.

Abstract: A control module is included in a battery charger that is adapted to charge a plurality of battery packs of different types or a power tool that is adapted to be powered by at least one of the battery packs. The control module includes a remote sensing module that communicates remotely with one of the battery packs. The control module also includes a battery pack connection module that determines that the one of the battery packs is in electrical communication with at least one of the battery charger and the power tool. The control module also includes a battery pack identification (ID) module that determines a first type of the battery pack based on remote sensing module signals. The control module also includes a charge control module that determines at least one of a charge setting and a discharge setting for the battery pack based on the first type.

Abstract: A computer implemented method of particular, although not exclusive application to analysing a plurality of molecules which comprises computing a kernel function for each pair of the plurality of molecules, the kernel function being representative of the number of features present in both molecules of the pairs and using the kernel function in a kernel based learning algorithm to model the relationship between the features and a property of the molecules. The method is also applicable to predicting a numerical value representing a characteristic of a molecule and, more generally, modelling instances of data in a database. A particular, although again not exclusive application, is the prediction of toxicity of a molecule.

Abstract: The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. 1(a)). The article is comprised of an outer layer (1) having an inner layer-facing side and an opposite side; an inner layer (3) having an outer layer-facing side and an opposite side, the inner layer (3) joined to the outer layer (1) to form one or more closed material reservoir (2) between the outer layer-facing side of the inner layer (2) and the inner layer-facing side of the outer layer (1); and adhesive (4) covering a first portion of the opposite side of the inner layer (3), wherein the adhesive (4) is a heat activated adhesive that changes color and/or is activated when the article is subjected to elevated temperatures, thereby sealing the transdermal dosage form within the article.

Abstract: The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.

Abstract: In one embodiment, an ammonium removal method can comprise: removing a multivalent cation from a stream comprising ammonium to form a treated stream; converting the ammonium in the stream to ammonia by increasing the pH of the stream; and separating the ammonia from the treated stream to form a separated stream and gaseous ammonia. In another embodiment, an ammonium removal method can comprise: a multivalent cation from a stream comprising ammonium to form a treated stream comprising a total of less than or equal to about 50 ppm by weight of multivalent cations; increasing the pH of the stream to a conversion pH; converting the ammonium to ammonia; and separating the ammonia from the treated stream to form a separated stream and gaseous ammonia.

Abstract: An integrated filler system to transfer a filler product from a filler product source to a product receptacle is provided. The integrated filler system includes a cylinder housing, a pallet valve disposed within the cylinder housing that contains a product flow aperture, and a piston inserted in a valve bore of the pallet valve. A linear actuator is connected to the piston to selectively actuate a linear travel of the piston within the valve bore. A rotary actuator is connected to the pallet valve to selectively position the product flow aperture to fluidly communicate with either a product input port or a product output port formed in the cylinder housing.

Abstract: A connector assembly is disclosed and claimed. The male connector comprises at least one conductive terminal held by a male plug body including a head portion and a gripping portion, the head portion including a plurality of raised elements extending radially outward from the head portion. The female connector comprises at least one mating conductive terminal held by a female plug body including a receiving portion and a gripping portion, the receiving portion adapted to receive the head portion of the male connector and including a plurality of recessed areas adapted to interlock with the raised elements of the head portion. The male plug body is preferably made from a substantially rigid plastic and the female plug body is made from a flexible plastic.

Abstract: An air spring suspension damper assembly includes a first housing and a second housing which telescope relative to each other. An actuating member such as a cable is connected to a height leveling valve contained in one of the housings and attached to the other housing. The actuating member moves a member such as a rotating cam, a rotating valve plate and/or a rotating valve such that changes in the suspension height rotate the member. Rotation of the member selectively opens inlet and exhaust flow paths to control the air pressure in the damper assembly and maintain air suspension height at a predetermined height.

Abstract: The invention comprises a transdermal dosage form comprising an active agent component comprising an active agent and an adverse agent component comprising an adverse agent, wherein the active agent component defines at least one channel extending substantially there through.

Abstract: A connector assembly is disclosed and claimed. The male connector comprises at least one conductive terminal held by a male plug body including a head portion and a gripping portion, the head portion including a plurality of raised elements extending radially outward from the head portion. The female connector comprises at least one mating conductive terminal held by a female plug body including a receiving portion and a gripping portion, the receiving portion adapted to receive the head portion of the male connector and including a plurality of recessed areas adapted to interlock with the raised elements of the head portion. The male plug body is preferably made from a substantially rigid plastic and the female plug body is made from a flexible plastic.

Abstract: A multiple dose delivery device for delivering a medicament into an oral cavity of a patient is provided. The device includes a sachet pack including a plurality of unit doses of a medicament enclosed between a first strip and a second strip. The device further includes a sachet advance mechanism and a mouthpiece. Upon actuation by a user, the sachet advance mechanism, which is engaged with the sachet pack, separates the first strip from the second strip to release one of the plurality of the unit doses from the sachet pack. The mouthpiece includes an opening, and each released unit dose passes through the opening.

Abstract: A system for firing a spark plug is disclosed. The system includes a timing controller configured to send a first timing signal and a second timing signal. The system also includes an ignition transformer having a primary winding and a secondary winding and a spark-plug that is operably associated with the secondary winding. A first switching element is disposed between the timing controller and the primary winding of the ignition transformer. The first switching element controls a supply of power to the primary winding based on the first timing signal. Also, a second switching element is disposed between the timing controller and the primary winding of the ignition transformer. The second switching element controls the supply of power to the primary winding based on the second timing signal. A method for firing a spark plug is also disclosed.

Abstract: The present invention provides a two compartment device (10), and method of use, for the disposal of used transdermal dosage forms (26) and the dispensing of unused transdermal dosage forms (28). The first compartment (12) has a dosage form inlet (16) and a detector (20), and the second compartment (14) has a dosage form outlet (22) in communication with the detector (20). The detector (20) permits the dispensing of an unused transdermal dosage (28) form from the outlet (22).

Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.

Abstract: The invention comprises a transdermal dosage form comprising an active agent component comprising an active agent and an adverse agent component comprising an adverse agent, wherein the active agent component defines at least one channel extending substantially there through.