Abstract: Contemplated antiviral/cancer treatments comprise analysis of neoepitopes from viral DNA that has integrated into the host genome, and design of immunotherapeutic agents against such neoepitopes.

Abstract: A driveline includes a rotor adaptor and a bearing adaptor coupled to opposite ends of a drive shaft. The rotor adaptor includes a first plurality of drive pockets. Each of the first plurality of drive pockets receives a drive ball rotatably held between each of the first plurality of drive pockets and the end of the drive shaft. The bearing adaptor includes a second plurality of drive pockets. Each of the second plurality of drive pockets receives a drive ball rotatably held between each of the second plurality of drive pockets and the opposite end of the drive shaft. Each of the plurality of drive balls includes a flat surface and each of the first plurality of drive pockets and the second plurality of drive pockets includes a flat thrust face. The flat surface receives a rotational force from the flat thrust face in response to rotating the rotor adaptor.

Abstract: The invention provides a method of validating the therapeutic composition that is prepared for immunotherapy of a tumor or cancer. The method includes, triggering of an immune response to a neoepitope of a subject's tumor by: a) obtaining neoepitope sequence data from the tumor of a subject; b) obtaining immune competent cells; c) using the neoepitope sequence data to generate a neoepitope presentation system; d) triggering an immune response by contacting the immune competent cells with the neoepitope presentation system; and e) quantifying the triggering of the immune response from the contacted immune competent cells.

Abstract: Described is a computer-implemented method which comprises receiving a plurality of images captured by at least one user device, wherein each image is associated with one of a corresponding plurality of geographic locations; determining a path between the plurality of geographic locations; determining a confidence indicator representative of whether the determined path corresponds to a demarked path, wherein determining the confidence indicator comprises determining a time of capture of each of the plurality of images; identifying the path as corresponding to a demarked route, based on the confidence indicator; and marking the plurality of images for display as a demarked route.

Abstract: Methods and apparatuses are described herein. In an example embodiment, a glass-break detector is provided. Glass-break detector includes a speaker and a microphone in sound communication with the glass and is configured to perform an echo signature procedure to generate a baseline echo signature. The echo signature procedure includes: causing the speaker to transmit an ultrasonic signal onto the surface of the glass, causing the microphone to measure sound wave amplitudes on the surface of the glass, and generating an echo signature based on the sound wave amplitudes. Glass-break detector is configured to repeat the echo signature procedure to generate a test echo signature and detect a break in the glass based at least on the baseline echo signature and the test echo signature.

Abstract: An example dispensing spout for solid items includes a first body tube portion and a second body tube portion. The first body tube portion may comprise a slide portion. The second body tube portion may comprise a connection portion for connecting the dispensing spout onto a dispenser. The slide portion may comprise a slide surface extending from an open dispensing end to a distal slide end. Solid items dispensed by the dispenser may pass through the body tube before sliding down the slide portion. The solid items fall off of the distal slide end, for example, into a collecting tray.

Abstract: Disclosed autonomous mobile robot systems can be used to safely and efficiently navigate through a facility while avoiding objects in the path of the autonomous mobile robot during completion of a task. Specifically, a first bounded area based on first sensor data may be generated around an autonomous mobile robot where the first sensor data is used to identify objects in a travel path for the autonomous mobile robot and determine a speed for navigating the facility. A second bounded area of a size less than the first bounded area may be generated around the autonomous mobile robot based on speed information from propulsion components of the autonomous mobile robot. A new travel path and new speed information may be generated based on identifying an object in the travel path, dimensional measurements of a space around the object, and a current size of the second bounded area.

Abstract: An inventory management system can include a fleet of mobile drive units. The mobile drive units can detect, using a sensor, calibration data associated with a calibration fixture. The calibration of the sensors can be updated based on the calibration data. The calibration data for the fleet of mobile drive units can be used determine a correction factor. The correction factor can be applied to the fleet of mobile drive units to further update the calibration of the sensors.

Abstract: Autonomous mobile robots (AMRs) having adaptive safety systems may operate individually or as part of a convoy. During individual operations, an AMR may determine a safety zone and stop responsive to detecting an object within the safety zone. During convoy operations, an AMR may selectively mute a portion of the safety zone and allow a forward AMR of a convoy within the portion of the safety zone. In this manner, the adaptive safety systems may enable convoy operations of multiple AMRs with relatively greater density and greater speed, thereby improving speed and efficiency of AMR operations without negatively impacting safety.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: Techniques for data management are described. A monotonically increasing time source that indicates an elapsed time since a reference event may be activated. Multiple snapshots of a computing object may be generated in accordance with a schedule for backing up the computing object, where the schedule may include a retention duration for retaining snapshots. Based on generating the snapshots, timestamps for the snapshots may be stored, where the timestamps may indicate respective values of the monotonically increasing time source. As part of an expiration job, a reference value of the monotonically increasing time source may be identified based on the retention duration and a current value indicated by the monotonically increasing time source. Also, a snapshot of the snapshots may be expired based on a timestamp of the snapshot corresponding to a value of the monotonically increasing time source that is less than the reference value.

Abstract: A method is provided for vaporized hydrogen peroxide cleaning of a chamber. The method includes altering a temperature of air in the chamber from an initial temperature to a sterilization temperature over a first time period. The method also includes injecting vaporized hydrogen peroxide into air in the chamber to alter a relative humidity of hydrogen peroxide vapor in the chamber to a sterilization level over the first time period. The method also includes maintaining the temperature at the sterilization temperature and the relative humidity at the sterilization level over a second time period. The method also includes reducing the relative humidity from the sterilization level to a safe level over a third time period. In one embodiment, the method is provided for vaporized hydrogen peroxide cleaning of an interior chamber of an incubation container. In other embodiments, the incubation chamber featured in the method is provided.

Abstract: A system comprises an imaging device for imaging within a body of a patient. The imaging device comprises a flexible elongate member and an imaging assembly disposed at a distal portion of the flexible elongate member. The imaging assembly comprises an array of imaging elements and a plurality of electronic components configured to perform an electrical function associated with imaging within the body of the patient using the array of imaging elements. Each of the plurality of electronic components is radiopaque such that the plurality of electronic components comprises a radiopaque pattern at the distal portion of the flexible elongate member. A method of imaging within a patient body comprises receiving a radiographic image representative of an ultrasound imaging device positioned within the patient body and determining an orientation of the ultrasound imaging device using a radiopaque pattern of a plurality of electronic components in the radiographic image.

Abstract: A corrosion resistant bimetal includes a part and one or more sacrificial anodes. The part includes a metal component that is susceptible to corrosion. The sacrificial anodes consists of an attachment to the part through a metallic bond between the metal component and the sacrificial anode to form a crystalline solid that includes the sacrificial anode and the metal component of the part.

Abstract: The present invention relates to sensors and methods for detecting bacterial proteases in a sample. In particular, the present invention relates to sensors and methods for detecting Pseudomonas spp. protease activity in a sample. The sensors and methods may be used to detect or predict spoilage of a dairy product. The invention also relates to methods for preparing samples for protease assays.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: Described is a computer-implemented method which comprises receiving a plurality of images captured by at least one user device, wherein each image is associated with one of a corresponding plurality of geographic locations; determining a path between the plurality of geographic locations; determining a confidence indicator representative of whether the determined path corresponds to a demarked path, wherein determining the confidence indicator comprises determining a time of capture of each of the plurality of images; identifying the path as corresponding to a demarked route, based on the confidence indicator; and marking the plurality of images for display as a demarked route.

Abstract: Techniques for data management are described. A monotonically increasing time source that indicates an elapsed time since a reference event may be activated. Multiple snapshots of a computing object may be generated in accordance with a schedule for backing up the computing object, where the schedule may include a retention duration for retaining snapshots. Based on generating the snapshots, timestamps for the snapshots may be stored, where the timestamps may indicate respective values of the monotonically increasing time source. As part of an expiration job, a reference value of the monotonically increasing time source may be identified based on the retention duration and a current value indicated by the monotonically increasing time source. Also, a snapshot of the snapshots may be expired based on a timestamp of the snapshot corresponding to a value of the monotonically increasing time source that is less than the reference value.