Abstract: Disclosed herein are methods of identifying homologous recombination deficiency (HRD) in omics data, comprising generating a mutational spectrum from omics data; and using the mutational spectrum in a trained model to identify HRD. Further disclosed herein are methods of treating a tumor that has HRD score indicating significant HRD events, comprising: obtaining omics data from a tumor sample and generating a mutational spectrum from omics data; using the mutational spectrum in a trained model to identify HRD in the omics data from the tumor sample; identifying the cancer as likely responsive to treatment with a PARP inhibitor upon determination of HRD; and administering a PARP inhibitor treatment for the tumor upon determination of a high HRD score.

Abstract: The present disclosure relates to a method for treating an electromembrane process aqueous composition comprising sodium and/or potassium sulfate, said process comprising removing water from said electromembrane process aqueous composition under conditions suitable for substantially selectively precipitating sodium and/or potassium sulfate monohydrate.

Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

Abstract: Disclosed are various embodiments for optimizing robot utilization in autonomous mobile robots by accounting for the battery charge state when assigning missions to be performed by the autonomous mobile robots in a material handling facility. In particular, mission data associated with one or more missions and robot data including a battery charge state associated with one or more robots can be analyzed to determine a robot mission assignment that accounts for battery state charge in order to maximize robot utilization and productivity of material handling tasks.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: There are provided processes comprising submitting an aqueous composition comprising lithium sulphate and/or bisulfate to an electrolysis or an electrodialysis for converting at least a portion of said sulphate into lithium hydroxide. During electrolysis or electrodialysis, the aqueous composition is at least substantially maintained at a pH having a value of about 1 to about 4; and converting said lithium hydroxide into lithium carbonate.

Abstract: A corrosion resistant bimetal includes a part and one or more sacrificial anodes. The part includes a metal component that is susceptible to corrosion. The sacrificial anodes consists of an attachment to the part through a metallic bond between the metal component and the sacrificial anode to form a crystalline solid that includes the sacrificial anode and the metal component of the part.

Abstract: There are provided methods for preparing lithium carbonate. For example, such methods can comprise reacting an aqueous composition comprising lithium hydroxide with CO2 by sparging the CO2 the said composition, thereby obtaining a precipitate comprising the lithium carbonate. The methods can also comprise inserting at least a portion of the precipitate into a clarifier and obtaining a supernatant comprising lithium bicarbonate and a solid comprising the lithium carbonate, separating the solid from the supernatant; and heating the supernatant at a desired temperature so as to at least partially convert the lithium bicarbonate into lithium carbonate.

Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

Abstract: Techniques for data management are described. A monotonically increasing time source that indicates an elapsed time since a reference event may be activated. Multiple snapshots of a computing object may be generated in accordance with a schedule for backing up the computing object, where the schedule may include a retention duration for retaining snapshots. Based on generating the snapshots, timestamps for the snapshots may be stored, where the timestamps may indicate respective values of the monotonically increasing time source. As part of an expiration job, a reference value of the monotonically increasing time source may be identified based on the retention duration and a current value indicated by the monotonically increasing time source. Also, a snapshot of the snapshots may be expired based on a timestamp of the snapshot corresponding to a value of the monotonically increasing time source that is less than the reference value.

Abstract: A link assembly (3) for an agricultural ground engaging chain (1) including a plurality of link assemblies, the link assembly including: a first component (7) having a first clamping portion (21) and a first link portion (13) for linking with a link portion of an adjacent link assembly; a second component (9) having a second clamping portion (27) and a second link portion (15) for linking with a link portion of an adjacent link assembly; a harrow member (5) has a first side (17) and an opposite second side (19); at least one resilient spring plate (22) wherein the resilient spring plate is elastically deformable, and at least one fastening element (11). The resilient spring plate urges the first and second components (7, 9) to retain the components of the link assembly together.

Abstract: Systems and methods are presented that allow for predicting treatment response of a tumor to a checkpoint inhibitor. In one exemplary aspect, the treatment response is directly associated with a relatively high number of patient- and tumor-specific immunologically visible neoepitopes. Specific mutational patterns in the nucleic acid encoding the neoepitope may be further indicative of treatment response.

Abstract: Contemplated cancer treatments comprise recursive analysis of patient-, cancer-, and location-specific neoepitopes from various biopsy sites of a patient after treatment or between successive rounds of immunotherapy and/or chemotherapy to inform further immunotherapy. Recursive analysis preferably includes various neoepitope attributes to so identify treatment relevant neoepitopes.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: An autonomous robot system to enable flexible, safe, efficient, and automated movement of goods and materials in a dynamic environment including one or more dynamic objects (e.g., humans). The autonomous robot system includes a modular autonomous ground vehicle (AGV) including a vehicle management system having a safety management system. The safety management system includes one or more safety management controllers to perform safety functions to enable the modular AGV to operate safely and efficiently alongside humans in a dynamic environment (e.g., a warehouse or fulfillment facility).

Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Abstract: A dispensing apparatus (1) for delivering droplets of fluids such as liquids having a low viscosity or being soft gels onto poultry hatchlings that are present in movably mounted hatchling trays (19) comprising at least one reservoir (18), at least one pumping unit (9), connected to at least one reservoir (18), with at least one manifold (8) connected to at least one pumping unit (9), as well as a control unit. The apparatus comprises a plurality of optionally adjustable fluid atomizers (6) being connected by flexible connecting means (7) to at least one manifold (8), whereby the fluid atomizers (6) are detachably and/or slidably connected on at least one mounting rail (5), and that optionally different types of fluid atomizers (6) are distributed onto the mounting rail (5). Additionally, a method for delivering fluid droplets onto poultry hatchlings present in moving hatchling trays (19) is described.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array (302) of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit (304) adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate (375) adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: A distributed, online machine learning system is presented. Contemplated systems include many private data servers, each having local private data. Researchers can request that relevant private data servers train implementations of machine learning algorithms on their local private data without requiring de-identification of the private data or without exposing the private data to unauthorized computing systems. The private data servers also generate synthetic or proxy data according to the data distributions of the actual data. The servers then use the proxy data to train proxy models. When the proxy models are sufficiently similar to the trained actual models, the proxy data, proxy model parameters, or other learned knowledge can be transmitted to one or more non-private computing devices. The learned knowledge from many private data servers can then be aggregated into one or more trained global models without exposing private data.