Abstract: In a method for managing compensatory transactions between vehicles, a compensation engine determines relative priorities of the first and second vehicles. The compensation engine determines compensation between the first and second vehicles based on the relative priorities of the first and second vehicles. Following the determination of compensation, the compensation engine executes a transfer of compensation between the first and second vehicles.

Abstract: A device for transferring a pressurized fluid from a stationary source into a rotating spindle shaft includes a stationary housing including an internal socket having a socket wall and a rotatable shaft extending into the socket. The shaft includes an outer surface and a shaft bore having inlet and outlet ends. The device includes a washer positioned over the shaft and including a first flat side surface and a second side surface having at least a portion angled with respect to the first flat side surface in operative contact with the socket wall. The device includes a bushing positioned over the shaft and including a bore having an inner surface spaced apart from the outer surface of the shaft by a gap. The bushing includes a first end surface proximate the inlet end and a second end surface in operative contact with the first flat side surface of the washer.

Abstract: A distributed, online machine learning system is presented. Contemplated systems include many private data servers, each having local private data. Researchers can request that relevant private data servers train implementations of machine learning algorithms on their local private data without requiring de-identification of the private data or without exposing the private data to unauthorized computing systems. The private data servers also generate synthetic or proxy data according to the data distributions of the actual data. The servers then use the proxy data to train proxy models. When the proxy models are sufficiently similar to the trained actual models, the proxy data, proxy model parameters, or other learned knowledge can be transmitted to one or more non-private computing devices. The learned knowledge from many private data servers can then be aggregated into one or more trained global models without exposing private data.

Abstract: Systems and methods are presented that allow for determination and prediction of payload toxicity in therapeutic viruses. Disclosed herein are methods of determining payload toxicity of an expressed polypeptide in a cell, comprising: generating or procuring a plurality of expression vectors, each containing a different recombinant nucleic acid sequence that encodes a corresponding recombinant polypeptide; expressing the recombinant nucleic acid sequence in a plurality of host cells while culturing the host cells; sequencing the plurality of expression vectors after culturing the host cells; and correlating at least portions of the recombinant nucleic acid sequence with a toxicity measure.

Abstract: Contemplated compositions and methods are directed to cancer neoepitopes and uses of such neoepitopes, especially to generate synthetic antibodies against neoepitopes that may then be employed in the manufacture of a therapeutic agent. Preferred therapeutic agents will comprise a synthetic antibody against a neoepitope, and most preferably in combination with a cellular or non-cellular component for use as a diagnostic or therapeutic agent.

Abstract: A method is provided for vaporized hydrogen peroxide cleaning of a chamber. The method includes altering a temperature of air in the chamber from an initial temperature to a sterilization temperature over a first time period. The method also includes injecting vaporized hydrogen peroxide into air in the chamber to alter a relative humidity of hydrogen peroxide vapor in the chamber to a sterilization level over the first time period. The method also includes maintaining the temperature at the sterilization temperature and the relative humidity at the sterilization level over a second time period. The method also includes reducing the relative humidity from the sterilization level to a safe level over a third time period. In one embodiment, the method is provided for vaporized hydrogen peroxide cleaning of an interior chamber of an incubation container. In other embodiments, the incubation chamber featured in the method is provided.

Abstract: Techniques are described for a computing system to synchronize project data between media applications. A method includes (a) operating a first project adapter module to convert a first media project generated by a first media application from a first project format into a generalized project format, thereby generating a generalized project; (b) operating a synchronization service to manage a set of contextual rules; (c) operating a second project adapter module to convert, with reference to the set of contextual rules, the generalized project into a second project format used by a second media application, thereby generating a second media project; and (d) viewing the second media project using the second media application. A system, apparatus, and computer program product for performing this method and similar methods are also described.

Abstract: The present disclosure relates to a method for extracting lithium from a lithium-containing material. For example, the method can comprise leaching a roasted lithium-containing material under conditions suitable to obtain an aqueous composition comprising a lithium compound such as lithium sulfate and/or lithium bisulfate. The aqueous composition comprising lithium sulfate and/or lithium bisulfate can optionally be used, for example, in a method for preparing lithium hydroxide comprising an electromembrane process. The roasted lithium-containing material can be prepared, for example by a method which uses an aqueous composition comprising optionally lithium sulfate and/or lithium bisulfate which can be obtained from a method for preparing lithium hydroxide comprising an electromembrane process such as a two-compartment monopolar or bipolar electrolysis process.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: Certain universal neoepitopes and cancer specific neoepitopes and methods therefore are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.

Abstract: Described is a computer-implemented method which comprises receiving a plurality of images captured by at least one user device, wherein each image is associated with one of a corresponding plurality of geographic locations; determining a path between the plurality of geographic locations; determining a confidence indicator representative of whether the determined path corresponds to a demarked path, wherein determining the confidence indicator comprises determining a time of capture of each of the plurality of images; identifying the path as corresponding to a demarked route, based on the confidence indicator; and marking the plurality of images for display as a demarked route.

Abstract: The present invention relates to the desulfurisation of lead-containing waste. In particular, the present invention relates to a method in which lead-containing waste is desulfurised to form a desulfurised lead-containing waste material which is suitable for recycling into lead or leady oxide. The method is particularly suitable for desulfurising lead-acid battery paste.

Abstract: A distributed, online machine learning system is presented. Contemplated systems include many private data servers, each having local private data. Researchers can request that relevant private data servers train implementations of machine learning algorithms on their local private data without requiring de-identification of the private data or without exposing the private data to unauthorized computing systems. The private data servers also generate synthetic or proxy data according to the data distributions of the actual data. The servers then use the proxy data to train proxy models. When the proxy models are sufficiently similar to the trained actual models, the proxy data, proxy model parameters, or other learned knowledge can be transmitted to one or more non-private computing devices. The learned knowledge from many private data servers can then be aggregated into one or more trained global models without exposing private data.

Abstract: Therapeutic T cells can be prepared from a population of TILs (tumor infiltrating lymphocytes) using tumor and patient-specific neoantigens expressed in antigen presenting cells to select for tumor reactive T cells. Selected tumor reactive T cells are then expanded and administered to the patient.

Abstract: Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.

Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.

Abstract: Contemplated compositions and methods are directed to cancer neoepitopes and uses of such neoepitopes, especially to generate synthetic antibodies against neoepitopes that may then be employed in the manufacture of a therapeutic agent. Preferred therapeutic agents will comprise a synthetic antibody against a neoepitope, and most preferably in combination with a cellular or non-cellular component for use as a diagnostic or therapeutic agent.

Abstract: Aspects of the disclosure relate to visualization of lateral movements of an intruder on a network by connecting to computers and/or resources under investigation. A first computer is identified for investigation. Logs regarding incoming and outgoing connections to the computer are extracted and can be prefiltered based on specific IDs or other criteria. Maps of incoming and outgoing connections are stored in memory along with event information. Each subsequent computer to which the computer connected or resource accessed is identified. The map is updated based on logs from that computer or resource. A graphical image showing each applicable host, its connections, the chronology, and/or contextual information is generated and displayed. Individual hosts and other displayed data can be user-selectable to drill down and/or provide additional information. The process can repeat until all hosts, from patient zero to all endpoints, have been identified and rendered.

Abstract: There are provided methods for preparing lithium carbonate. For example, such methods can comprise reacting an aqueous composition comprising lithium hydroxide with CO2 by sparging the CO2 the said composition, thereby obtaining a precipitate comprising the lithium carbonate. The methods can also comprise inserting at least a portion of the precipitate into a clarifier and obtaining a supernatant comprising lithium bicarbonate and a solid comprising the lithium carbonate, separating the solid from the supernatant; and heating the supernatant at a desired temperature so as to at least partially convert the lithium bicarbonate into lithium carbonate.