Abstract: The present disclosure provides polymorphs of 3-(2,3,5,6-tetrafluoro-3?-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid, and methods of making such polymorphs. The present disclosure further provides pharmaceutical compositions and kits comprising polymorphs of the invention, and methods of treating, preventing, or ameliorating a disease or condition comprising administering a polymorph of the invention.

Abstract: The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.

Abstract: The invention relates to a solid dosage form comprising a core-shell structure comprising two or more different active agents, wherein the core-shell structure comprises (1) a core comprising a first matrix formulation, the first matrix formulation comprising at least one active agent selected from the group of an active agent (A) and an active agent (B); and (2) a shell encasing the core and comprising a second matrix formulation, wherein the weight ratio of the first matrix formulation to the second matrix formulation is from about 1:10 to about 4:1. In certain embodiments, the solid dosage forms of the invention are in oral solid extended release dosage forms, which provide an extended release of at least a portion of at least one active agent included therein.

Abstract: The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.

Abstract: A technology is described for a wide-band radio frequency amplifier using cross-over diplexers. A first port is configured to receive RF signals in a wide-band RF spectrum. A cross-over diplexer splitter is coupled to the first port. The cross-over diplexer splitter is configured to filter the RF signals in the wide-band RF spectrum into a low frequency (LF) signal having an LF pass-band and a high frequency (HF) signal having an HF pass-band with the LF pass-band crossing the HF pass-band at a cross-over frequency. An HF RF amplifier is configured to amplify the HF signal to form an amplified HF signal. An LF RF amplifier configured to amplify the LF signal to form an amplified LF signal. A cross-over diplexer combiner is configured to combine the amplified HF signal and the amplified LF signal and output amplified RF signals in the wide-band RF spectrum.

Abstract: A device may queue a thread for execution by a thread pool, including configuring an ambient context with a cancellation token. Based on a call of a synchronous method by the thread, the device may determine that the thread uses a green threads model and identify the cancellation token from the ambient context. Based on the thread using the green threads model, the device may call an asynchronous method that uses an asynchronous operation to perform a task of the synchronous method, including passing the asynchronous method the cancellation token. Based on identifying a state change of the cancellation token, the device may terminate the asynchronous operation.

Abstract: Utilizing role types that extend underlying types. Within a program definition, a computer system identifies a statement assigning an object of an underlying type to a role type that extends the underlying type. The underlying type implements a first interface, and the role type implements a second interface. Based on the role type extending the underlying type, the computer system assigns the object of the underlying type to the role type. Based on assigning the object of the underlying type to the role type, the role type is usable to interact with the object of the underlying type using both the first interface and the second interface.

Abstract: The present disclosure provides polymorphs of 3-(2,3,5,6-tetrafluoro-3?-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid, and methods of making such polymorphs. The present disclosure further provides pharmaceutical compositions and kits comprising polymorphs of the invention, and methods of treating, preventing, or ameliorating a disease or condition comprising administering a polymorph of the invention.

Abstract: The disclosure provides a method of treating interstitial cystitis/bladder pain syndrome in a human subject in need of such treatment, comprising administering to the human subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. In certain embodiments, the method comprises administering the compound of formula (IA).

Abstract: The invention relates to a solid dosage form comprising a core-shell structure comprising two or more different active agents, wherein the core-shell structure comprises (1) a core comprising a first matrix formulation, the first matrix formulation comprising at least one active agent selected from the group of an active agent (A) and an active agent (B); and (2) a shell encasing the core and comprising a second matrix formulation, wherein the weight ratio of the first matrix formulation to the second matrix formulation is from about 1:10 to about 4:1. In certain embodiments, the solid dosage forms of the invention are in oral solid extended release dosage forms, which provide an extended release of at least a portion of at least one active agent included therein.

Abstract: Techniques are described herein that are capable of constructing a finite automaton using regular expression derivatives to simulate behavior of a backtracking engine. The behavior indicates an order in which paths in an input regular expression are to be evaluated by the backtracking engine. The finite automaton is constructed to include a graph that includes a root node that represents the input regular expression. Regular expressions are derived such that each derived regular expression is a regular expression derivative of the input regular expression or of another derived regular expression. Priorities are assigned to alternations in the derived regular expressions to correspond to priorities indicated by the behavior. Nodes that represent the respective derived regular expressions and transitions between respective pairs of nodes are caused to be included in the graph. Priorities, which correspond to the order, are assigned to respective branches of the graph.

Abstract: Improved compilers recognize interception declarations in source code, and emit code that replaces invocations of specified artifacts with invocations of specified interceptors instead. Source generators proactively modify program behavior in arbitrary desired ways without introducing hidden security violations and without requiring edits by the program's developers. Interception declarations are visible in source code and development tools. In some cases, different invocations of a particular method at respective locations are intercepted by different replacement methods. Replacement methods have identical signatures, or are otherwise compatible. Some interceptors specify optional parameters. Method calls, field accesses, and property calls may be intercepted. Work to modify program behavior is moved in the program lifecycle from runtime to compile time, thus improving runtime performance and eliminating JIT compilation security risks.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.

Abstract: A single asynchronous enumerable object is generated that contains the data and methods needed to iterate through an enumerable asynchronously. The asynchronous enumerable object contains the code for traversing the enumerable one step at a time and the operations needed to suspend an iteration to await completion of an asynchronous operation and to resume the iteration upon completion of the asynchronous operation. The allocation of a single object to perform all of these tasks reduces the memory consumption needed to execute an asynchronous enumeration.

Abstract: Techniques are described herein that are capable of constructing a finite automaton using regular expression derivatives to simulate behavior of a backtracking engine. The behavior indicates an order in which paths in an input regular expression are to be evaluated by the backtracking engine. The finite automaton is constructed to include a graph that includes a root node that represents the input regular expression. Regular expressions are derived such that each derived regular expression is a regular expression derivative of the input regular expression or of another derived regular expression. Priorities are assigned to alternations in the derived regular expressions to correspond to priorities indicated by the behavior. Nodes that represent the respective derived regular expressions and transitions between respective pairs of nodes are caused to be included in the graph. Priorities, which correspond to the order, are assigned to respective branches of the graph.

Abstract: Utilizing role types that extend underlying types. Within a program definition, a computer system identifies a statement assigning an object of an underlying type to a role type that extends the underlying type. The underlying type implements a first interface, and the role type implements a second interface. Based on the role type extending the underlying type, the computer system assigns the object of the underlying type to the role type. Based on assigning the object of the underlying type to the role type, the role type is usable to interact with the object of the underlying type using both the first interface and the second interface.

Abstract: A turbine shroud assembly for a gas turbine engine includes a shroud wall extending circumferentially partway around a central reference axis to define a gas path of the gas turbine engine. An attachment feature extends radially from the shroud wall. A foam is located at least on the shroud wall.

Abstract: A system and method for recommending demand-supply agent pairs for transactions uses a deep neural network on data of demand agents to produce a demand agent vector, which is used to select supply agents based on their likelihood of future transaction and to find k nearest neighbor demand agents for each of the demand agents. The candidate supply agents and the k nearest neighbor demand agents are then combined to produce candidate demand-supply agent pairs, which are used to find recommended demand-supply agent pairs by applying modeling using machine learning.