Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HC dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: A method of controllably coating a fiber preform has been developed. The method includes infiltrating a fiber preform with a first solvent to form a solvent-filled preform. After the infiltration, a slurry is applied to one or more outer surfaces of the solvent-filled preform to form a slurry coating thereon. The slurry coating comprises particulate solids dispersed in a second solvent having a vapor pressure higher than that of the first solvent. The slurry coating and the solvent-filled preform are dried. During drying, the second solvent evaporates from the slurry coating before the first solvent evaporates from the solvent-filled preform. The slurry coating dries to form a porous surface coating comprising the particulate solids on the one or more outer surfaces of the solvent-filled preform. The drying of the solvent-filled preform continues after formation of the porous surface coating to remove the first solvent.

Abstract: A porous fiber preform enclosed within a mold may be melt infiltrated by pouring a molten material through an inlet of the mold, the porous fiber preform comprising ceramic fibers. A ceramic matrix composite component comprising the ceramic fibers may be formed by solidifying the molten material that is in the mold and in the porous fiber preform.

Abstract: A method of making a fiber preform for ceramic matrix composite (CMC) fabrication that utilizes a fugitive binder and a machining step is described. The method includes, according to one embodiment, laying up a plurality of plies to form a stack, where each ply comprises an arrangement of fibers. The stack is infiltrated with a polymer at an elevated temperature to form an infiltrated stack that is cooled to form a rigid preform. The rigid fiber preform is machined to have a predetermined shape, such that a machined fiber preform is formed. A composite assembly including the machined fiber preform is formed and then the composite assembly is heated at a sufficient temperature to pyrolyze the polymer. Thus, a porous preform of a predetermined geometry is formed for further processing into a CMC.

Abstract: An apparatus for coating specimens includes a reaction chamber and a plurality of reaction modules in the reaction chamber for containing specimens to be coated, where each reaction module includes a module inlet and a module outlet. A plurality of conduits are configured to be in fluid communication with at least one gas source external to the reaction chamber, and each of the conduits terminates in one of the reaction modules for delivery of gaseous reagents to the specimens to be coated. The module outlets are in fluid communication with the reaction chamber for expulsion of gaseous reaction products from the reaction modules.

Abstract: Described technologies support selectively tracing a process's execution, with some extra tracing done beyond the code the developer wanted traced, but with significantly reduced computational cost, by reducing the number of trace enablement and disablement operations. A trace controller uses a tracing disablement distance variable whose values indicate the computational distance from trace disablement. A distance variable modifier automatically moves the distance variable closer to a stop-tracing value as the process executes. A create task function is modified to include the setting of an indicator that a newly created task is to be traced if a current task or thread is being traced. An execute task function is modified to request the tracing of the newly created task when it is executed based on the indicator, thereby enabling selective tracing that operates across process boundaries and traces asynchronous code execution.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. The blades each fit within slots formed in the rotor disk to couple the blades to the rotor disk. Platform segments are arranged about each of the blades.

Abstract: A blade assembly for use in a gas turbine engine. The blade assembly includes a blade, a platform distinct from the blade and configured to extend around the blade, and a pin that couples the platform with the blade.

Abstract: An asynchronous method is implemented in a manner that reduces the amount of runtime overhead needed to execute the asynchronous method. The data elements needed to suspend an asynchronous method to await completion of an asynchronous operation, to resume the asynchronous method at a resumption point, and to provide a completion status of the caller of the asynchronous method are consolidated into one or two reusable objects. An asynchronous method may be associated with a distinct object pool of reusable objects. The size of a pool and the total size of all pools can be configured statically or dynamically based on runtime conditions.

Abstract: A method of making a fiber preform for ceramic matrix composite (CMC) fabrication comprises laminating an arrangement of fibers between polymer sheets comprising an organic polymer, which may function as a fugitive binder during fabrication, to form a flexible prepreg sheet. A plurality of the flexible prepreg sheets are laid up in a predetermined geometry to form a stack, and the stack is heated to soften the organic polymer and bond together the flexible prepreg sheets into a bonded prepreg structure. Upon cooling of the bonded prepreg structure, a rigid preform is formed. The rigid preform is heated at a sufficient temperature to pyrolyze the organic polymer. Thus, a porous preform that may undergo further processing into a CMC is formed.

Abstract: An asynchronous method is implemented in a manner that reduces the amount of runtime overhead needed to execute the asynchronous method. The data elements needed to suspend an asynchronous method to await completion of an asynchronous operation, to resume the asynchronous method at a resumption point, and to provide a completion status of the caller of the asynchronous method are consolidated into one or two reusable objects. An asynchronous method may be associated with a distinct object pool of reusable objects. The size of a pool and the total size of all pools can be configured statically or dynamically based on runtime conditions.

Abstract: A method of making a ceramic fiber tow and the system regarding the same may be included. The method may include commingling a plurality of ceramic fibers with a fugitive fiber to form a single ceramic fiber tow. The fugitive fiber may be positioned between at least two ceramic fibers included in the single ceramic fiber tow. The method may further include forming a porous ceramic preform including at least the single ceramic fiber tow. The method may further include removing the fugitive fiber from the ceramic fiber tow leaving a space between at least two ceramic fibers of the single ceramic fiber tow. The method may further include replacing the spaces between ceramic fibers included in the ceramic fiber tows with a ceramic matrix.

Abstract: Described are systems and methods for dynamically generating advertisements for presentation in an application executing on a user device, such as an application executing on a smart phone or tablet of a user. An ad server system provides various ad templates, each of which include one or more tokens at different locations within the ad templates. The same token may be included in multiple different ad templates at the same of different locations. Based on user profile and/or conditions at the time of ad presentation, an appropriate template is selected and used to dynamically generate the ad.

Abstract: Described are systems and methods for dynamically generating advertisements for presentation in an application executing on a user device, such as an application executing on a smart phone or tablet of a user. An ad server system provides various ad templates, each of which include one or more tokens at different locations within the ad templates. The same token may be included in multiple different ad templates at the same of different locations. Based on user profile and/or conditions at the time of ad presentation, an appropriate template is selected and used to dynamically generate the ad.

Abstract: A system for performing audio-enhanced, simulated ultrasound examinations may generally include an ultrasound simulation device having at least one processor and associated memory. The memory may store pre-recorded audio-enhanced ultrasound data for at least one internal organ. The audio-enhanced ultrasound data may include a moving ultrasound image of the at least one internal organ along with synced audio data associated with auscultatory sounds generated by the at least one internal organ depicted within the moving ultrasound image. In addition, the system may include a display and a speaker coupled to the ultrasound simulation device. The display may be configured to display the moving ultrasound image as a trainee is performing the simulated ultrasound examination. The speaker may be configured to broadcast the synced audio data simultaneously with the display of the moving ultrasound image.

Abstract: Disclosed is a method and apparatus for an environmental control system in which a genetic learning algorithm creates scenes and scene triggers and in which a fitness function scores the scenes through end-user interaction.

Abstract: A system for performing audio-enhanced, simulated ultrasound examinations may generally include an ultrasound simulation device having at least one processor and associated memory. The memory may store pre-recorded audio-enhanced ultrasound data for at least one internal organ. The audio-enhanced ultrasound data may include a moving ultrasound image of the at least one internal organ along with synced audio data associated with auscultatory sounds generated by the at least one internal organ depicted within the moving ultrasound image. In addition, the system may include a display and a speaker coupled to the ultrasound simulation device. The display may be configured to display the moving ultrasound image as a trainee is performing the simulated ultrasound examination. The speaker may be configured to broadcast the synced audio data simultaneously with the display of the moving ultrasound image.

Abstract: A ceramic matrix composite (CMC) is formed by infiltrating a metal or alloy into a fiber preform in a reactor or furnace that is separated into multiple discrete temperature zones. The gradual cooling of the CMC is controlled, such that upon solidification, a narrow, planar, solidification front is created which allows the expanding metal or alloy to move into a hotter section of the fiber preform, opposed to the surface of the CMC. A discrete solidification front is established that moves through the ceramic matrix composite (CMC) as the composite cools.

Abstract: A ceramic matrix composite includes continuous silicon carbide fibers in a ceramic matrix comprising silicon carbide and a MAX phase compound having a chemical composition Mn+1AXn, where M is a transition metal selected from the group consisting of: Ti, V, Cr, Sc, Zr, Nb, Mo, Hf, and Ta; A is a group-A element selected from the group consisting of: Al, Si, P, S, Ga, Ge, As, Cd, In, Sn, Tl and Pb; and X is carbon or nitrogen, with n being an integer from 1 to 3.

Abstract: Processes and methods for making biobased acrylic acid products including acrylic acid, acrylic acid oligomers, acrylic acid esters, acrylic acid polymers and articles from renewable carbon resources are described herein.