Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HC dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: This application relates to solid forms of an S1P-receptor modulator, which are useful in the treatment of diseases or disorders associated with activity of S1P, including CNS disorders.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.

Abstract: A method of altering a surface of a ceramic matrix composite to aid in nodule removal is described. A fiber preform comprising a framework of ceramic fibers is heated to a temperature at or above a melting temperature of silicon. During the heating, the fiber preform is infiltrated with a molten material comprising silicon. After the infiltration, the fiber preform is cooled, and the infiltrated fiber preform is exposed to a gas comprising nitrogen during cooling. Silicon nitride may be formed by a reaction of free (unreacted) silicon at or near the surface of the infiltrated fiber preform with the nitrogen. Thus, a ceramic matrix composite having a surface configured for easy nodule removal is formed. Any silicon nodules formed on the surface during cooling may be removed without machining or heat treatment.

Abstract: A carrying bag with a water resistant Velcro® outer case and an activated carbon inner liner provides an odor proof capability. The Velcro® outer surface provides for user selected placement of one or more removable patch attachments. The invention described here reduces the need to purchase alternative backpacks due to endless user configuration of possible looks. The carry bag may include one or more carry handles and one or more shoulder straps.

Abstract: A computer system is provided comprising one or more processors, one or more memories and one or more programs stored in one or more of the memories for execution by one or more of the processors, the system updating a database that links organizations with intellectual property rights to create associations between related organizations, and being programmed to carry out the process of: performing a search, using an internet search engine, for a first entry from the database containing data indicative of the name of an organization associated with one or more rights to produce a first set of web page results for the first entry; performing a search, using an internet search engine, for a second entry from the database containing data indicative of the name of an organization associated with one or more rights to produce a second set of web page results for the second entry; comparing the first set of results and the second set of results to identify matches between the first set of results and the second set

Abstract: Described are systems and methods for dynamically generating advertisements for presentation in an application executing on a user device, such as an application executing on a smart phone or tablet of a user. An ad server system provides various ad templates, each of which include one or more tokens at different locations within the ad templates. The same token may be included in multiple different ad templates at the same of different locations. Based on user profile and/or conditions at the time of ad presentation, an appropriate template is selected and used to dynamically generate the ad.

Abstract: A method of making a fiber preform for ceramic matrix composite (CMC) fabrication comprises laminating an arrangement of fibers between polymer sheets comprising an organic polymer, which may function as a fugitive binder during fabrication, to form a flexible prepreg sheet. A plurality of the flexible prepreg sheets are laid up in a predetermined geometry to form a stack, and the stack is heated to soften the organic polymer and bond together the flexible prepreg sheets into a bonded prepreg structure. Upon cooling of the bonded prepreg structure, a rigid preform is formed. The rigid preform is heated at a sufficient temperature to pyrolyze the organic polymer. Thus, a porous preform that may undergo further processing into a CMC is formed.

Abstract: A blade assembly for use in a gas turbine engine. The blade assembly includes a blade, a platform distinct from the blade and configured to extend around the blade, and a pin that couples the platform with the blade.

Abstract: A method of controllably coating a fiber preform has been developed. The method includes infiltrating a fiber preform with a first solvent to form a solvent-filled preform. After the infiltration, a slurry is applied to one or more outer surfaces of the solvent-filled preform to form a slurry coating thereon. The slurry coating comprises particulate solids dispersed in a second solvent having a vapor pressure higher than that of the first solvent. The slurry coating and the solvent-filled preform are dried. During drying, the second solvent evaporates from the slurry coating before the first solvent evaporates from the solvent-filled preform. The slurry coating dries to form a porous surface coating comprising the particulate solids on the one or more outer surfaces of the solvent-filled preform. The drying of the solvent-filled preform continues after formation of the porous surface coating to remove the first solvent.

Abstract: Described technologies support selectively tracing a process's execution, with some extra tracing done beyond the code the developer wanted traced, but with significantly reduced computational cost, by reducing the number of trace enablement and disablement operations. A trace controller uses a tracing disablement distance variable whose values indicate the computational distance from trace disablement. A distance variable modifier automatically moves the distance variable closer to a stop-tracing value as the process executes. A create task function is modified to include the setting of an indicator that a newly created task is to be traced if a current task or thread is being traced. An execute task function is modified to request the tracing of the newly created task when it is executed based on the indicator, thereby enabling selective tracing that operates across process boundaries and traces asynchronous code execution.

Abstract: An apparatus for coating specimens includes a reaction chamber and a plurality of reaction modules in the reaction chamber for containing specimens to be coated, where each reaction module includes a module inlet and a module outlet. A plurality of conduits are configured to be in fluid communication with at least one gas source external to the reaction chamber, and each of the conduits terminates in one of the reaction modules for delivery of gaseous reagents to the specimens to be coated. The module outlets are in fluid communication with the reaction chamber for expulsion of gaseous reaction products from the reaction modules.

Abstract: The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.

Abstract: A single asynchronous enumerable object is generated that contains the data and methods needed to iterate through an enumerable asynchronously. The asynchronous enumerable object contains the code for traversing the enumerable one step at a time and the operations needed to suspend an iteration to await completion of an asynchronous operation and to resume the iteration upon completion of the asynchronous operation. The allocation of a single object to perform all of these tasks reduces the memory consumption needed to execute an asynchronous enumeration.

Abstract: A carrying bag with a water resistant Velcro® outer case and an activated carbon inner liner provides an odor proof capability. The Velcro® outer surface provides for user selected placement of one or more removable patch attachments. The invention described here reduces the need to purchase alternative backpacks due to endless user configuration of possible looks. The carry bag may include one or more carry handles and one or more shoulder straps.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. The blades each fit within slots formed in the rotor disk to couple the blades to the rotor disk. Platform segments are arranged about each of the blades.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, two branch segments extending from each end of the central segment, and an extension segment extending from each of the four branch segments, to collectively form four unenclosed cell openings that are each semi-hexagonal in shape. Some embodiments include four reinforcement segments with each one extending into a respective cell opening, four voids with each one extending through respective adjacent branch and extension segments, an underbody gap formed under the central segment for refractory interlinking between cell openings, and/or a single stud-welding stud for the mounting feature.