Abstract: This application relates to solid forms of an S1P-receptor modulator, which are useful in the treatment of diseases or disorders associated with activity of S1P, including CNS disorders.

Abstract: A turbine vane assembly adapted for use in a gas turbine engine includes a support and a turbine vane arranged around the support. The support is made of metallic materials. The turbine vane is made of ceramic matrix composite materials to insulate the metallic materials of the support.

Abstract: A method of altering a surface of a ceramic matrix composite to aid in nodule removal is described. A fiber preform comprising a framework of ceramic fibers is heated to a temperature at or above a melting temperature of silicon. During the heating, the fiber preform is infiltrated with a molten material comprising silicon. After the infiltration, the fiber preform is cooled, and the infiltrated fiber preform is exposed to a gas comprising nitrogen during cooling. Silicon nitride may be formed by a reaction of free (unreacted) silicon at or near the surface of the infiltrated fiber preform with the nitrogen. Thus, a ceramic matrix composite having a surface configured for easy nodule removal is formed. Any silicon nodules formed on the surface during cooling may be removed without machining or heat treatment.

Abstract: The present disclosure provides polymorphs of 3-(2,3,5,6-tetrafluoro-3?-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid, and methods of making such polymorphs. The present disclosure further provides pharmaceutical compositions and kits comprising polymorphs of the invention, and methods of treating, preventing, or ameliorating a disease or condition comprising administering a polymorph of the invention.

Abstract: An airfoil assembly for a gas turbine engine includes an airfoil extending radially relative to a central reference axis. A spar is located within the airfoil and spaced from the airfoil at all radial locations along the airfoil such that a gap is maintained between the airfoil and the spar. A foam is located between the airfoil and the spar.

Abstract: The present application discloses methods, systems, and computer program products for automatically generating source code implementing a regular expression. A regular expression that is defined within source code of an application project is identified. The source code uses a higher-level programming language. Based on identifying the regular expression, a source code implementation of the regular expression is automatically generated using the higher-level programming language, and the source code implementation of the regular expression is integrated into the application project. After integrating the source code implementation of the regular expression into the application project, the source code implementation of the regular expression is compiled into lower-level code and the lower-level code is emitted into an application executable when building the application project, or the source code implementation of the regular expression is interpreted when executing the application project.

Abstract: A turbine shroud assembly for a gas turbine engine includes a shroud wall extending circumferentially partway around a central reference axis to define a gas path of the gas turbine engine. An attachment feature extends radially from the shroud wall. A foam is located at least on the shroud wall.

Abstract: An airfoil assembly for a gas turbine engine includes an airfoil extending radially relative to a central reference axis. A spar is located within the airfoil and spaced from the airfoil at all radial locations along the airfoil such that a gap is maintained between the airfoil and the spar. A foam is located between the airfoil and the spar.

Abstract: The present application discloses methods, systems, and computer program products for automatically generating source code implementing a regular expression. A regular expression that is defined within source code of an application project is identified. The source code uses a higher-level programming language. Based on identifying the regular expression, a source code implementation of the regular expression is automatically generated using the higher-level programming language, and the source code implementation of the regular expression is integrated into the application project. After integrating the source code implementation of the regular expression into the application project, the source code implementation of the regular expression is compiled into lower-level code and the lower-level code is emitted into an application executable when building the application project, or the source code implementation of the regular expression is interpreted when executing the application project.

Abstract: The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

Abstract: A turbine vane assembly adapted for use in a gas turbine engine includes a support and a turbine vane arranged around the support. The support is made of metallic materials. The turbine vane is made of ceramic matrix composite materials to insulate the metallic materials of the support.

Abstract: A computing device including a processor configured to receive source code including a plurality of source code modules. The processor may generate executable code from the source code and assign two or more reload indicators to two or more executable code modules. The processor may execute the executable code. During execution of the executable code, the processor may receive a source code update and generate an executable code update from the source code and the source code update. The processor may apply the executable code update to the executable code to generate updated executable code. The processor may generate a reload ordering of two or more reload operations corresponding to the reload indicators. As specified by the reload ordering, the processor may perform the two or more reload operations at the two or more respective executable code modules. The processor may execute the updated executable code.

Abstract: An asynchronous method is implemented in a manner that reduces the amount of runtime overhead needed to execute the asynchronous method. The data elements needed to suspend an asynchronous method to await completion of an asynchronous operation, to resume the asynchronous method at a resumption point, and to provide a completion status of the caller of the asynchronous method are consolidated into one or two reusable objects. An asynchronous method may be associated with a distinct object pool of reusable objects. The size of a pool and the total size of all pools can be configured statically or dynamically based on runtime conditions.

Abstract: Refractory anchoring devices include a main body and a mounting feature for mounting to a thermal vessel. The main body has the shape of two end-to-end Y's forming a central segment, branch segments extending from ends of the central segment, and extension segments extending from the branch segments, to collectively form four unenclosed cell openings that are semi-hexagonally shaped. Some embodiments include reinforcement segments extending into respective cell openings, voids extending through respective adjacent branch and extension segments, an underbody gap under the central segment, a single stud-welding stud for the mounting feature, and/or a collar-and-stud connection between the anchor main body and a stud-welding stud of the mounting feature. Refractory anchoring systems and methods include an array of the refractory anchoring devices arranged and mounted so that the unenclosed semi-hexagonal cell openings of adjacent anchoring devices cooperatively form substantially hexagonal cells.

Abstract: Hot reloading a running application with an unsaved source code change. A code change to a source code of a running software application that is associated with a project type is identified. The code change is stored within an in-memory editor buffer, and is uncommitted to any source code file. It is determined that the code change can be applied to the running software application using hot reload. Hot reload agent(s) associated with the project type are identified. Using the hot reload agent(s), the code change is communicated to an application runtime associated with the running software application. At least one process of the running software application invokes a new compiled code entity corresponding to the code change.

Abstract: A turbine vane assembly adapted for use in a gas turbine engine includes a spar, a turbine vane, and load transfer pins. The spar comprises metallic materials and is configured to support other components of the turbine vane assembly relative to an associated turbine case. The turbine vane comprises ceramic matrix composite materials and is shaped to include an airfoil configured to direct the flow of hot gasses through a primary gas path of the turbine vane assembly.

Abstract: A computing device including a processor configured to receive source code including a plurality of source code modules. The processor may generate executable code from the source code and assign two or more reload indicators to two or more executable code modules. The processor may execute the executable code. During execution of the executable code, the processor may receive a source code update and generate an executable code update from the source code and the source code update. The processor may apply the executable code update to the executable code to generate updated executable code. The processor may generate a reload ordering of two or more reload operations corresponding to the reload indicators. As specified by the reload ordering, the processor may perform the two or more reload operations at the two or more respective executable code modules. The processor may execute the updated executable code.

Abstract: A gas turbine engine system includes an engine component comprising ceramic matrix composite materials, at least one control system configured to control at least a temperature of the engine component, and a controller. The controller includes a degradation map stored therein. The degradation map includes degradation fields, each field defined by a unique range of temperatures and stresses of the component and correlated to different types of degradation of the component. The controller is configured to determine a first temperature and stress of the component and a first field based on the first temperature and stress, determine a second field different from the first and a second temperature and stress that would locate the component in the second field, and instruct the control system to change the temperature of the component from the first to the second temperature to locate the component in the second field.

Abstract: This application relates to solid forms of an S1P-receptor modulator, which are useful in the treatment of diseases or disorders associated with activity of S1P, including CNS disorders.

Abstract: Combined combustion and pyrolysis (CCP) systems, and associated systems and methods, are disclosed herein. In some embodiments, the CCP system includes an input valve fluidly coupleable to a fuel supply to receive a hydrocarbon reactant, a CCP reactor fluidly coupled to the input valve, and a carbon separation component fluidly coupled to the CCP reactor. The CCP reactor can include a combustion chamber, a reaction chamber in thermal communication with the combustion chamber and/or fluidly coupled to the input valve, and an insulating material positioned to reduce heat loss from the combustion chamber and/or the reaction chamber. The CCP reactor can also include a combustion component positioned to combust a fuel within the combustion chamber. The combustion can heat the reaction chamber and the hydrocarbon reactant flowing therethrough. The heat causes a pyrolysis of the hydrocarbon reactant that generates hydrogen gas and carbon.