Abstract: A sacrificial sealing layer is formed on a high-K metal gate (HKMG) stack to suppress oxidants, e.g., oxygen and water, from impacting the metal gate stack, thus preserving the device EOT. The method integrated processes that include forming an interfacial layer on the substrate; forming a high-K metal oxide layer on the interfacial layer, the high-K metal oxide layer comprising a dipole region adjacent to the interfacial layer, the dipole region; depositing a capping layer on the high-K metal oxide layer; and forming a sacrificial sealing layer on the capping layer. The dipole region is formed by driving a dopant species, e.g., zinc (Zn), vanadium (V), tungsten (W), molybdenum (Mo), ruthenium (Ru), titanium (Ti), tantalum (Ta), zirconium (Zr), aluminum (Al), niobium (Nb), or mixtures thereof, of a dipole film into the high-K metal oxide layer to form a dipole region.

Abstract: A metal gate stack on a substrate comprises: an interfacial layer on the substrate; a high-? metal oxide layer on the interfacial layer, the high-? metal oxide layer comprising a dipole region adjacent to the interfacial layer, the dipole region comprising niobium (Nb); a high-? metal oxide capping layer on the high-? metal oxide layer; a positive metal-oxide-semiconductor (PMOS) work function material above the high-? metal oxide capping layer; and a gate electrode above the PMOS work function material. The dipole region is formed by driving Nb species of a Nb-based film into the high-? metal oxide layer to form a dipole region.

Abstract: Compositions and methods to increase the in vivo capacity of CD8+ T cells to kill HIV-infected and reactivated latent HIV-infected T cells (LHITC) to functionally cure HIV infection or improve the clinical course. Compositions and methods to increase the in vivo capacity of CD8+ T cells to kill CMV or CMV-infected cells are also provided.

Abstract: The glenoid implant described here addresses wear of the implant's portion which articulates with a humeral head, and also addresses a frequent need to reverse the normal glenoid and humeral articulating surfaces. The new glenoid implant provides a coupling portion between the implant's bone fixation portion, which joins the implant to the glenoid bone, and the implant's articulating portion which articulates on an opposing humeral head. The coupling portion is joined to the bone fixation portion firmly but is disengageable without requiring the bone fixation portion's replacement so that the articulating portion can be removed from the implant and replaced without changing either the coupling portion or the bone fixation portion.

Abstract: An onboard rebreathing loop system resident on an aircraft for providing oxygen to aircraft personnel includes a ceramic oxygen generating system (COGS) module configured to receive an inlet air and output a high purity oxygen (O2) gas into a breathing loop and a carbon dioxide (CO2) scrubber module configured to receive exhaled air from the aircraft personnel and output a CO2-scrubbed air into the breathing loop. The high purity O2 gas and CO2-scrubbed air are mixed to form a mixed gas having a partial pressure of O2 suitable for breathing by the aircraft personnel. The onboard rebreathing loop system may further include an odor removal module, an air temperature and/or humidity control module to condition the mixed gas before breathing by the aircraft personnel, and a gas sensor module to confirm the partial pressure of O2 within the mixed gas before breathing by the aircraft personnel.

Abstract: Methods and apparatus for employing selective compression for addressing congestion control for Artificial Intelligence (AI) workloads. Multiple interconnected compute nodes are used for performing an AI workload in a distributed environment, such as training an AI model. Periodically, such as following an epoch for processing batches of training data in parallel, the compute nodes exchange Tensor data (e.g., local model gradients) with one another, which may lead to network/fabric congestion. Compute nodes and/or switches in the distributed environment are configured to detect current or projected network/fabric congestion and to selectively apply variable rate compression to packets containing the Tensor data to alleviate/avoid the congestion. Tensor data may be selectively applied at source compute nodes by computing a network pause time and comparing that time to a compression compute time.

Abstract: Apparatus and methods for performing charge detection mass spectrometry for measurement of the mass of a single ion of interest are disclosed. The ion of interest is caused to undergo harmonic oscillatory movement in the trapping field of an electrostatic trap, such that an image current detector generates a time-varying signal representative of the ion's oscillatory movement. This time-varying signal (transient) is processed (e.g., via a Fourier transform) to derive the ion's frequency and consequently determine the ion's mass-to-charge ratio (m/z). Ion charge is determined by construction of a Selective Temporal Overview of Resonant Ion (STORI) plot, which tracks the temporal evolution of signals attributable to the ion of interest, and where the slope of the STORI plot is related to the charge. The STORI plot may also be employed to identify ion decay events during transient acquisition and/or the presence of multiple ions of the same mass or non-resolvable ions.

Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: A variety of fill options is provided for a cell processing system. Certain options relate to a syringe assembly that receives a product directly from a separator. Other options relate to a filling system associated with the cell processing system, the filling system comprising one or more filling stations, each with at least one container, that receive product from a product container associated with the cell processing system.

Abstract: A system that calibrates timing relationships between signals involved in performing write operations is described. This system includes a memory controller which is coupled to a set of memory chips, wherein each memory chip includes a phase detector configured to calibrate a phase relationship between a data-strobe signal and a clock signal received at the memory chip from the memory controller during a write operation. Furthermore, the memory controller is configured to perform one or more write-read-validate operations to calibrate a clock-cycle relationship between the data-strobe signal and the clock signal, wherein the write-read-validate operations involve varying a delay on the data-strobe signal relative to the clock signal by a multiple of a clock period.

Abstract: Ablation electrode assemblies include an inner core member and an outer shell surrounding the inner core member. The inner core member and the outer shell define a space or separation region therebetween. The inner core member is constructed from a thermally insulative material having a reduced thermal conductivity. In an embodiment, the space is a sealed or evacuated region. In other embodiments, irrigation fluid flows within the space. The ablation electrode assembly further includes at least one thermal sensor in some embodiments. Methods for providing irrigation fluid during cardiac ablation of targeted tissue are disclosed that include calculating the energy delivered to irrigation fluid as it flows within the ablation electrode assembly through temperature measurement of the irrigation fluid. Pulsatile flow of irrigation fluid can be utilized in some embodiments of the disclosure.

Abstract: The creation, maintenance, and accessing of page tables is done by a virtual machine monitor running on a computing system rather than the guest operating systems. This allows page table walks to be completed in fewer memory accesses when compared to the guest operating system's maintenance of the page tables. In addition, the virtual machine monitor may utilize additional resources to offload page table access and maintenance functions from the CPU to another device, such as a page table management device or page table management node. Offloading some or all page table access and maintenance functions to a specialized device or node enables the CPU to perform other tasks during page table walks and/or other page table maintenance functions.

Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.

Abstract: A method of forming a gate stack structure includes forming a dipole metal layer on a high-? gate dielectric layer on a semiconductor structure formed on a substrate, annealing the dipole metal layer, and removing the dipole metal layer. The dipole metal layer comprises dopants in the high-? gate dielectric layer.

Abstract: Computing devices, methods, and systems for switch-based free memory tracking in data center environments are disclosed. An exemplary switch integrated circuit (IC), which is used in a switched fabric or a network, can include a processing device and a tracking structure that is distributed with at least a second switch IC. The tracking structure tracks free memory units that are accessible in a first set of nodes by the second switch IC. The processing device receives a request for a number of free memory units. The processing device forwards the request to a node in the first set of nodes that has at least the number of free memory units or forwards the request to the second switch IC that has at least the number of free memory units or responds to the request with a response that indicates that the request could not be fulfilled.

Abstract: A fiber optic ferrule includes a body extending from a first end to a second opposite end, with the body including an axial passage extending between the first and second ends. The axial passage includes a first diameter portion having a diameter of at least 125 microns, and a second diameter portion having a diameter of at least 250 microns and less than a diameter of the buffer, the second diameter portion positioned between the first diameter and the second end. The axial passage further defines a tapered shape at the second end extending inward from the second end to the second diameter portion. A hub holds the ferrule. A method of assembling a terminated fiber optic cable is also provided.

Abstract: A fiber optic connector and cable assembly includes a cable and a fiber optic connector. The connector has a main connector body, a ferrule, a spring for biasing the ferrule, and a spring push for retaining the spring within the main connector body. A crimp band is provided for securing the fiber optic cable to the fiber optic connector. The crimp band includes a first portion securing a cable strength member. The crimp band also includes a second portion crimped down on a jacket of the cable. The crimp band further includes an inner surface having gripping structures for gripping the strength member and/or the jacket.

Abstract: The disclosure relates to cationic polymers functionalized with substituted phenylboronic acid groups and to methods of using the same to treat metabolic and gastrointestinal disorders.

Abstract: An interconnected stack of one or more Dynamic Random Access Memory (DRAM) die has a base logic die and one or more custom logic or processor die. The processor logic die snoops commands sent to and through the stack. In particular, the processor logic die may snoop mode setting commands (e.g., mode register set—MRS commands). At least one mode setting command that is ignored by the DRAM in the stack is used to communicate a command to the processor logic die. In response the processor logic die may prevent commands, addresses, and data from reaching the DRAM die(s). This enables the processor logic die to send commands/addresses and communicate data with the DRAM die(s). While being able to send commands/addresses and communicate data with the DRAM die(s), the processor logic die may execute software using the DRAM die(s) for program and/or data storage and retrieval.

Abstract: A system includes processors configured to perform operations including obtaining a base design resource production of a building asset and a base resource production data set comprising a base resource production of the building asset at a plurality of operating points, calculating a scaled resource production data set comprising a scaled resource production of the building asset at the plurality of operating points by scaling the base resource production data set based on a new design resource production of the building asset relative to the base design resource production of the building asset, generating a resource consumption data set comprising a resource consumption of the building asset at the plurality of operating points based on the scaled resource production data set, and initiating an automated action based on the scaled resource production data set and the resource consumption data set.