Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor has a base, a first electrode and a second electrode wherein a thermocouple portion is provided integral with the second electrode thereby enabling on-sensor temperature measurement capability. In some embodiments, two and only two electrical contact engagement portions are provided thereby simplifying electrical contact. Manufacturing methods and systems utilizing the analyte sensors are provided, as are numerous other aspects.

Abstract: A stack of products such as pouches are formed in a product bucket, pushed into a stack guide bucket and from there into a carton. A stack tamp descends over the stack, engages and confines it downwardly during stack pushing from product bucket and through stack guide bucket into a carton. Multiple product buckets, stack guide buckets and cartons move downstream during cartoning, and are respectively aligned in a cartoning station. Reciprocal containment blades hold the stack in respective cartons prior to flap closing.

Abstract: The present disclosure relates to recyclable articles for transmitting and/or receiving radio waves therethrough having a frequency in the range of 0.5 GHz to 81 GHz. The recyclable articles include a thermoplastic resin including a polyamide and provide low signal attenuation of the radio waves transmitted or received therethrough. In various aspects, the recyclable article can be a car unibody or a vehicle monocoque.

Abstract: A method for providing consent for provisioning data in an opaque blockchain, includes: receiving, by a receiver of a processing server, a consent request for data associated with the processing server stored on a blockchain, the consent request including at least two digital signatures, where a first digital signature is generated by a regulating entity and a second digital signature is generated by a moderating entity in the blockchain network; validating, by a processing device of the processing server, the first digital signature and the second digital signature; digitally signing, by the processing device of the processing server, the received consent request using a private key of a first cryptographic key pair; and transmitting, by a transmitter of the processing server, the digitally signed consent request to the regulating entity.

Abstract: A method of igniting liquid fuel in a turbomachine combustor is provided. The method includes a step of initiating a flow of gaseous fuel from a gaseous fuel supply to a gaseous fuel nozzle. The method further includes a step of initiating a flow of liquid fuel from a liquid fuel supply to a primary liquid fuel cartridge. After initiating both the flow of gaseous fuel and the flow of liquid fuel, the method includes a step of igniting the flow of gaseous fuel and the flow of liquid fuel with an igniter. The method further includes a step of terminating the flow of gaseous fuel from the gaseous fuel supply to the gaseous fuel nozzle.

Abstract: One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In particular, differential phosphorylation of the nucleophosmin (NPM) polypeptide is an early marker of ischemic injuries such as kidney injury, AKI and ischemic renal cell injury. Another aspect of the technology relates to compositions and methods for the treatment of ischemia and kidney injury, including NPM inhibitory agents, including, but not limited to NPM inhibitory peptides for the treatment of ischemia and kidney injury.

Abstract: The disclosure relates to cationic boronic acid containing polymers and to methods of using the same to treat metabolic and gastrointestinal disorders.

Abstract: Provided is 5-(3-chloro-4-fluorophenyl)-7-cyclopropyl-3-(2-(3-fluoro-3-methylazetidin-1-yl)-2-oxoethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one and pharmaceutically acceptable salts thereof, and their uses in the treatment of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system.

Abstract: A wastewater sump assembly for receiving and disposing of undesired fluid and, in some cases, solid waste (collectively “wastewater”). A sump basin includes an upstanding wall a base and a top. A sensor in the form, e.g., of a float switch extends into the basin and is operable to actuate a pump to remove collective wastewater from the basin. The sensor depends from a sensor support that is supported distally within the basin in a vertical manner and is supported proximately within the basin in a horizontal manner, with securement of the sensor support not requiring traversal of the basin top and with the distal basin support not needing to be accessed vertically through a pump access aperture in the top.

Abstract: An entertainment enhancement system includes an infrared projection system configured to output an infrared image to a target surface. The infrared projection system includes a controller configured to coordinate projection of the infrared image with a separate action by generating instructions for projecting the infrared image based on data received by the controller indicative of an active status of the separate action and an infrared emitter configured to receive the generated instructions and emit the infrared image to the target surface. The system also includes a viewing device configured to be wearable by a user. The viewing device includes at least one lens and a filter assembly configured to shift the infrared image from an infrared frequency to a visible light frequency such that the infrared image is viewable on the target surface via the viewing device.

Abstract: Methods and compositions for treating symptoms of conditions such as but not limited to osteoarthritis and rheumatoid arthritis. The methods may feature direct intraarticular injection of a recombinant self-complementary adeno-associated virus (sc-rAAV) with a vector adapted to express a modified IL-1Ra peptide. The methods of the present invention may express a therapeutically effective amount of the modified IL-1Ra peptide so as to ameliorating symptoms associated with the condition being treated.

Abstract: A tester apparatus is provided. Slot assemblies are removably mounted to a frame. Each slot assembly allows for individual heating and temperature control of a respective cartridge that is inserted into the slot assembly. A closed loop air path is defined by the frame and a heater and cooler are located in the closed loop air path to cool or heat the cartridge with air. Individual cartridges can be inserted or be removed while other cartridges are in various stages of being tested or in various stages of temperature ramps.

Abstract: An industrial data presentation system leverages structured data types defined on industrial devices to generate and deliver meaningful presentations of industrial data. Industrial devices are configured to support structured data types referred to as basic information data types (BIDTs) comprising a finite set of structured information data types, including a rate data type, a state data type, an odometer data type, and an event data type. The BIDTs can be referenced by both automation models of an industrial asset and non-automation models of the asset, allowing data points of both types of models to be easily linked using a common data source nomenclature.

Abstract: Processing methods may be performed to produce semiconductor structures. The methods may include forming a silicon layer over a semiconductor substrate. The forming may include forming a silicon layer incorporating a dopant. The methods may include oxidizing a portion of the silicon layer while maintaining a portion of the silicon layer in contact with the semiconductor substrate. The oxidizing may drive a portion of the dopant through the silicon layer and into the semiconductor substrate.

Abstract: The subject disclosure provides systems and methods for application-specific network data filtering. Application-specific network data filtering may be performed by a sandboxed process prior to providing the network data to an application to which the network data is directed. Any malicious or otherwise potentially harmful data that is included in the network data may be removed by the application-specific network data filter or may be allowed to corrupt the application specific network data filtering operations within the sandbox, thereby preventing the malicious or harmful data from affecting the application or other portions of an electronic device. In one or more implementations, a first process such as an application-specific network data filtering process may request allocation of memory for the first process from second process, such as an application, that is separate from a memory manager of the electronic device.

Abstract: An apparatus may include a superstrate. The superstrate may have a body with a first side, a second side opposite the first side, and a first diameter. The superstrate may also include a mesa on the first side of the body. The mesa may have a second diameter. The center point of the body can be different from the center point of the mesa.

Abstract: A system and method are provided for improving vehicle awareness and safety by generating and transmitting alerts in response to detecting a hazard in the environment omnidirectional to a vehicle awareness system. Omnidirectional environment data, representing kinematic information pertaining to one or more physically detectable elements omnidirectional to the primary vehicle, is acquired by one or more sensors communicatively coupled to ta vehicle. The system analyzes the omnidirectional environment data to detect if one or more hazards in the omnidirectional environment data, representing a change in the kinetic behavior of the one or more physically detectable elements omnidirectional to the vehicle awareness system, has occurred. When the system detects one or more hazards in the omnidirectional environment data, the system generates and transmits an alert to vehicles, vehicle operators, mobile devices, or pedestrians at risk from the hazard.

Abstract: An input component for an electronic device can include a dial that defines an exterior surface and a shaft affixed to the dial. The dial and the shaft can be rotatable about a central axis of the shaft and the shaft can include a protruding portion that defines a channel. A collar can surround a portion of the shaft and can be at least partially disposed in the channel. A bushing can be positioned between the collar and the protruding portion of the shaft, with the bushing defining a groove.

Abstract: In described examples, each node between adjacent capacitive elements of a stack of series-coupled capacitive elements is biased during a reset mode, where each of the capacitive elements includes piezoelectric material. A strain-induced voltage is generated across each of the capacitive elements. Each of the strain-induced voltages is combined to generate a piezoelectric-responsive output signal during a sensing mode at a time different from the time of the reset mode.