Abstract: Routing and layout for an antenna are described. In one embodiment, the antenna comprises an aperture having a plurality of radio-frequency (RF) radiating antenna elements, wherein each antenna element of the plurality of RF radiating antenna elements comprises an iris slot opening and an electrode over the iris slot opening; a plurality of drive transistors coupled to the plurality of antenna elements; and a plurality of storage capacitors, each storage capacitor coupled to the electrode of one antenna element of the plurality of antenna elements. The aperture also comprises at least one of: the drive transistor for the one antenna element is located under the electrode of the antenna element, the storage capacitor for the one antenna element is located under the electrode of the antenna element, and the metal routing to the one antenna element for a first voltage overlaps, in an overlap region, a common voltage routing that routes the common voltage to the one antenna element to form a storage capacitance.

Abstract: A system for 5G radio access networks, that enables smart RF signal repeater devices to perform many of the functions of a 5G base station to extend millimeter wave coverage for 5G communication networks while reducing costs, increasing versatility and optimizing coverage for user devices (UEs). The devices may include outdoor network repeaters and indoor subscriber repeaters, and other mmWave network transmitter devices in a mmWave network. Different types of 5G wireless communication networks may be employed including Open Radio Access Network (O-RAN), and Next Gen Radio Access Network (NG-RAN).

Abstract: A mount includes a rectangular shaped back surface configured to interface to a surface of a separate object, a first side surface perpendicular to the rectangular back surface and having a first arch-shaped cutout, and a second side surface perpendicular to the rectangular back surface and having a second arch-shaped cutout, wherein each of the first arch-shaped cutout and the second arch-shaped cutout comprises a first arch having a first radius and a second arch having a second radius, different from the first radius, the first radius of the first arch allows the mount to receive a cylindrical-shaped capacitor having a first diameter and the second radius of the second arch allows the mount to receive a cylindrical-shaped capacitor having a second diameter, different from the first diameter, and a channel configured to receive a strap and that extends through the mount, the channel having a closed channel portion, a first open channel portion, and a second open channel portion, wherein the strap extended t

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A glass manufacturing apparatus can include a conduit connected to a delivery vessel and an inlet of a forming vessel. The conduit includes a closed sidewall surrounding a channel extending in a flow direction of the conduit. The closed sidewall is continuous from the delivery vessel to the inlet of the forming vessel to define a closed atmosphere from the delivery vessel, through the conduit, and through the inlet of the forming vessel. The glass manufacturing apparatus can include a heating enclosure including a heating wall and a first heating element. The heating wall surrounds a chamber within which the conduit extends. The first heating element is positioned within the chamber between the heating wall and the conduit to increase a temperature within the channel. Methods for manufacturing a glass ribbon with a glass manufacturing apparatus are provided.

Abstract: An example system is configured for displaying enhancement options and financial analysis. The system may include a server, third party data sources and an augmented reality computing device that includes a processing unit and system memory. The augmented reality computing device is configured to obtain user input regarding a property enhancement option; render the property enhancement options in augmented reality; obtain financial data from the server and the third party data sources; responsive to the obtained user input, automatically generate a financial analysis of the property enhancement option, wherein the financial analysis is based on the obtained financial data; and render the financial analysis with the obtained property enhancement option in augmented reality.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: A glass manufacturing apparatus can include a conduit connected to a delivery vessel and an inlet of a forming vessel. The conduit includes a closed sidewall surrounding a channel extending in a flow direction of the conduit. The closed sidewall is continuous from the delivery vessel to the inlet of the forming vessel to define a closed atmosphere from the delivery vessel, through the conduit, and through the inlet of the forming vessel. The glass manufacturing apparatus can include a heating enclosure including a heating wall and a first heating element. The heating wall surrounds a chamber within which the conduit extends. The first heating element is positioned within the chamber between the heating wall and the conduit to increase a temperature within the channel. Methods for manufacturing a glass ribbon with a glass manufacturing apparatus are provided.

Abstract: A transformer assembly includes: a first switching apparatus configured to be electrically connected to a first segment of a transformer loop; a second switching apparatus configured to be electrically connected to a second segment of the transformer loop; and a transformer including: a first coil electrically connected to the first switching apparatus and the second switching apparatus; and a second coil electrically connected to an output configured to electrically connect to a load.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: Routing and layout for an antenna are described. In one embodiment, the antenna comprises an aperture having a plurality of radio-frequency (RF) radiating antenna elements, wherein each antenna element of the plurality of RF radiating antenna elements comprises an iris slot opening and an electrode over the iris slot opening; a plurality of drive transistors coupled to the plurality of antenna elements; and a plurality of storage capacitors, each storage capacitor coupled to the electrode of one antenna element of the plurality of antenna elements. The aperture also comprises at least one of: the drive transistor for the one antenna element is located under the electrode of the antenna element, the storage capacitor for the one antenna element is located under the electrode of the antenna element, and the metal routing to the one antenna element for a first voltage overlaps, in an overlap region, a common voltage routing that routes the common voltage to the one antenna element to form a storage capacitance.

Abstract: A depth sensing dilator system for dilating a penetration in a tissue plane includes an elongate flexible body, having a proximal end and a distal end. The body has a tapered dilator segment, and at least a first electrode on a distal end of the body. The system includes a processor and a user interface output device. The processor is configured to send a first signal to the output device when a change in impedance at the first electrode indicates that the first electrode has reached a predetermined relationship with the tissue plane.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Compounds of Formula (I) or (Ia) or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or (Ia) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: Expansion compensation structures for an antenna are disclosed. In one embodiment, the antenna comprises: an array of antenna elements; and a structure coupled to the array of antenna elements, the structure having a plurality of components comprising materials having different coefficients of thermal expansion (CTEs), wherein first and second components of the plurality of components are pin bonded with one or more pins, and one or more components of the plurality of components other than the first and second components are between the first and second components and have one or more slots through which the one or more pins traverse and have CTEs different than CTEs of the first and second components.

Abstract: A transseptal crossing system can have a sheath and an elongate tubular body. The tubular body can include an electrically conductive sidewall defining a central lumen and a distal end section. The central lumen may be configured to receive a guidewire and to permit at least a portion of the guidewire to extend through a distal opening of the electrically conductive sidewall. The distal end section can comprise a distal end surface in electrical communication with the electrically conductive sidewall. The distal end surface includes a first section being positioned generally perpendicular to a longitudinal axis of the elongate tubular body and a second section being positioned at a non-orthogonal angle relative to the longitudinal axis of the elongate tubular body. At least one of the first section or the second section may be configured to deliver energy to a target tissue.

Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.