Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A stabilizing retractor system for distal radius fracture repair includes a backing plate configured to support the back of the wrist and having a first side accessible on a first side of the wrist, a second side accessible on a second side of the wrist. A first soft tissue retractor is engageable with the backing plate and has a first radius engaging concavity on a first side, and a first soft tissue retracting surface on a second side. A second soft tissue retractor is engageable with the backing plate and has a second radius engaging concavity on a first side, and a first soft tissue retracting surface on a second side. The first and second tissue retractors may be advanced apart from each other to retract tissue, and retained by a tie which connects the first and second retractors around the back of the backing plate.

Abstract: A compound of formula (I): wherein Ring A, Q, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X, a, b, c and d are as defined in the specification.

Abstract: A system for 5G radio access networks, that enables smart RF signal repeater devices to perform many of the functions of a 5G base station to extend millimeter wave coverage for 5G communication networks while reducing costs, increasing versatility and optimizing coverage for user devices (UEs). The devices may include outdoor network repeaters and indoor subscriber repeaters, and other mmWave network transmitter devices in a mmWave network. Different types of 5G wireless communication networks may be employed including Open Radio Access Network (O-RAN), and Next Gen Radio Access Network (NG-RAN).

Abstract: A unit cell can be used for a metasurface, metamaterial, or beamforming antenna. The unit cell includes a metal layer attached to a substrate. The metal layer defines an iris opening for the unit cell. One or more tunable capacitance devices are positioned within or across the iris opening. Each tunable capacitance device is to tune resonance frequency of the unit cell. Mass transfer technologies or self-assembly processes may be used to position the tunable capacitance devices.

Abstract: The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: An actuator assembly for actuating an electrical switch housed in sealed electrical enclosure is disclosed. The actuator assembly includes a handle assembly including a handle positioned on an exterior of a cover of the sealed enclosure, a trip bracket positioned within the sealed enclosure and a shaft connecting the handle to the trip bracket. A slider actuator is slidably mounted over an electrical switch positioned within the enclosure and operatively associated with or coupled to a toggle of the electrical switch. The slider actuator has a drive link which is adapted to engage the trip bracket such that rotation of the handle activates the drive link which causes linear movement of the slider actuator to move the electrical switch between on and off positions. The use of the slider actuator allows a higher density of electrical switches to be stacked within the sealed enclosure.

Abstract: A common cooling system and method for multiple generators are disclosed. In certain embodiments, a system comprises a power generation unit comprising a plurality of generators, wherein the power generation unit provides power to well stimulation equipment, and a common cooling unit positioned remote from the power generation unit, wherein cooling fluid from the common cooling unit is provided to each generator of the plurality of generators in the power generation unit.

Abstract: A radiolucent, 3-D printed soft tissue retractor includes an elongate, curved support body having a long central axis that exceeds the length of a short, transverse axis. A bone engaging concavity is provided on a first side of the body. A concave soft tissue retracting surface is provided on a second side of the body. An inflection point is provided on the body in between the bone engaging concavity and the soft tissue retracting surface. The soft tissue retractor is configured to cooperate with a second soft tissue retractor and a backing plate to retract tissue and stabilize bones during a surgical distal radius fracture repair.

Abstract: The apparatus and methods include moving an optical fiber over a fiber path that includes a marking location at which resides a marking unit that dispenses an ink-jet stream. A centering method is performed whereby the optical fiber is incrementally moved in a lateral direction through the path of the ink-stream and the mark number density of marks formed on the optical fiber is measured along with the optical fiber position. A process window is defined by the range of lateral fiber positions over which a target mark number density is formed on a consistent basis. A controller calculates an optimum fiber path position and stores it memory for future reference while also moving the fiber path to the optimum position. The initially wet ink marks are dried and the fiber coated with a transparent protective overcoat to form a coated and marked optical fiber.

Abstract: Provided is an insulation liner for use inside a shipping carton that affords thermal insulation and shock absorption for an object to be shipped, a liner and carton system, a method of production of the insulation liner, and methods of use. The insulation liner includes a larger component folded into three panels, a smaller component folded into three panels, and standoffs disposed on the surfaces of both the larger component and the smaller component. The standoffs may be oriented inwardly or outwardly. When oriented outwardly they create an interstitial air space that reduces conduction allowing the insulation effect of the liner and carton system to equal or exceed that of a molded polystyrene container of an equal size.

Abstract: A system for 5G radio access networks, that enables smart RF signal repeater devices to perform many of the functions of a 5G base station to extend millimeter wave coverage for 5G communication networks while reducing costs, increasing versatility and optimizing coverage for user devices (UEs). The devices may include outdoor network repeaters and indoor subscriber repeaters, and other mmWave network transmitter devices in a mmWave network. Different types of 5G wireless communication networks may be employed including Open Radio Access Network (O-RAN), and Next Gen Radio Access Network (NG-RAN).

Abstract: A transformer assembly includes: a first switching apparatus configured to be electrically connected to a first segment of a transformer loop; a second switching apparatus configured to be electrically connected to a second segment of the transformer loop; and a transformer including: a first coil electrically connected to the first switching apparatus and the second switching apparatus; and a second coil electrically connected to an output configured to electrically connect to a load.

Abstract: An apparatus for exchanging liquid crystal (LC) between two areas of an antenna array in an antenna and method for using the same are disclosed. In one embodiment, the antenna comprises an antenna element array formed using portions of first and second substrates with a liquid crystal (LC) therebetween, and a structure between the first and second substrates and in an area outside of, and at an outer periphery of, the antenna element array to collect LC from an area between the first and second substrates forming the RF antenna elements due to LC expansion and to provide LC to the area between the first and second substrates forming the RF antenna elements due to LC contraction, the structure having a plurality of support spacers between the first and second substrates.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: An apparatus for exchanging liquid crystal (LC) between two areas of an antenna array and method for using the same are disclosed. In one embodiment, the antenna comprises an antenna element array having a plurality of radiating radio-frequency (RF) antenna elements formed using portions of first and second substrates with a liquid crystal (LC) therebetween, and a structure between the first and second substrates and outside the area of the RF antenna elements to collect LC from an area between the first and second substrates forming the RF antenna elements due to LC expansion.

Abstract: A stabilizing retractor system for distal radius fracture repair includes a backing plate configured to support the back of the wrist and having a first side accessible on a first side of the wrist, a second side accessible on a second side of the wrist. A first soft tissue retractor is engageable with the backing plate and has a first radius engaging concavity on a first side, and a first soft tissue retracting surface on a second side. A second soft tissue retractor is engageable with the backing plate and has a second radius engaging concavity on a first side, and a first soft tissue retracting surface on a second side. The first and second tissue retractors may be advanced apart from each other to retract tissue, and retained by a tie which connects the first and second retractors around the back of the backing plate.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: A method implemented on an electronic computing device includes obtaining an inventory of items in a property. Financial information is associated with one or more of the items. A status is monitored regarding maintenance and recalls of one or more of the items. Based on the status and using the financial information, at least one recommendation is provided for maintenance or replacement of one or more of the items.