Abstract: A method and apparatus for electrical addressing for an antenna (e.g., a metamaterial radio-frequency (RF) antenna are described. In one embodiment antenna comprising: a plurality of radio-frequency (RF) radiating antenna elements located in a plurality of rings; and matrix drive circuitry coupled to the plurality of RF radiating antenna elements to drive the antenna elements, wherein the matrix drive circuitry to uniquely address each of the antenna elements using a matrix of a plurality of rows and a plurality of columns with a non-grid-based addressing structure.

Abstract: Disclosed is a stabilizing retractor system for orthopedic fracture repair. A backing plate is configured to support the back of a wrist or ankle. At least a first soft tissue retractor includes a first support body having a first bone engaging concavity on a first side of the body on a distal portion of the body, configured to engage a first side of a bone. A first soft tissue retracting surface is provided on a second side of the body, proximal to the bone engaging concavity. A second soft tissue retractor may be provided for engaging a second side of the bone. The retractors may be pinned to the bone, and may be radiolucent.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: A method and apparatus for electrical addressing for an antenna (e.g., a metamaterial radio-frequency (RF) antenna are described. In one embodiment antenna comprising: a plurality of radio-frequency (RF) radiating antenna elements located in a plurality of rings; and matrix drive circuitry coupled to the plurality of RF radiating antenna elements to drive the antenna elements, wherein the matrix drive circuitry to uniquely address each of the antenna elements using a matrix of a plurality of rows and a plurality of columns with a non-grid-based addressing structure.

Abstract: A self-contained, battery powered transseptal crossing system is disclosed. An elongate, flexible electrically conductive needle body has a proximal end and a distal end. An insulation layer surrounds the sidewall and leaves exposed a distal electrode tip. A generator is configured to deliver RF energy to the electrode tip, and includes a processor configured to take impedance measurements at the tip to confirm contact with the intra atrial septum and/or confirm entry into the left atrium.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: An antenna has radio-frequency (RF) antenna elements and two substrates. A heater structure is connected to at least one of the two substrates, for heating the RF antenna elements. In one embodiment, the antenna comprises: a physical antenna aperture having an array of radio frequency (RF) antenna elements formed with patch and iris substrates, the iris substrate having a plurality of layers including an iris metal layer; and a heater structure coupled to one or more of the plurality of layers of the iris substrate for heating the RF antenna elements.

Abstract: A radio-frequency (RF) antenna and method for using the same are disclosed. In some embodiments, an antenna includes an array of RF radiating antenna elements, a plurality of RF antenna element driving circuits coupled to the array of RF radiating antenna elements to supply tuning voltages to the RF radiating antenna elements, and one or more metal power planes, each of the one or more metal power planes coupled to supply a common voltage to two or more of the plurality of RF antenna driving circuits.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: A self-contained, battery powered transseptal crossing system is disclosed. An elongate, flexible electrically conductive needle body has a proximal end and a distal end. An insulation layer surrounds the sidewall and leaves exposed a distal electrode tip. A generator is configured to deliver RF energy to the electrode tip, and includes a processos configured to take impedance measurements at the tip to confirm contact with the intra atrial septum and / or confirm entry into the left atrium.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Methods and apparatuses for performing optical inspection of varactor diodes in an antenna are disclosed. In some embodiments, the method of testing an antenna having varactor diodes comprises: selecting a plurality of varactor diodes to be placed in a light emitting state; forward biasing the selected varactor diodes to a magnitude at which the selected varactor diodes are to emit light; and detecting one or more faulty varactor diodes of the selected varactor diodes based on their emitted light intensity.

Abstract: Antennas with tunable elements and methods for using the same are disclosed. In some embodiments, an antenna comprises: a plurality of radio-frequency (RF) radiating antenna elements, wherein each antenna element of the plurality of RF radiating antenna elements comprises a tunable element, circuitry connected to the tuning element to set a voltage on the tunable element. In some embodiments, the circuitry comprises a voltage storage structure, a first transistor having a first gate connected to the voltage storage structure, a first source connected to the tunable element, and a first drain for coupling to a constant voltage source, and a data voltage input terminal operable to apply a voltage to the voltage storage structure and to the first gate to determine current through the first transistor.

Abstract: A radiolucent, 3-D printed soft tissue retractor includes an elongate, curved support body having a long central axis that exceeds the length of a short, transverse axis. A bone engaging concavity is provided on a first side of the body. A concave soft tissue retracting surface is provided on a second side of the body. An inflection point is provided on the body in between the bone engaging concavity and the soft tissue retracting surface. The soft tissue retractor is configured to cooperate with a second soft tissue retractor and a backing plate to retract tissue and stabilize bones during a surgical distal radius fracture repair.

Abstract: A self-contained, battery powered transseptal crossing system is disclosed. An elongate, flexible electrically conductive needle body has a proximal end and a distal end. An insulation layer surrounds the sidewall and leaves exposed a distal electrode tip. A generator is configured to deliver RF energy to the electrode tip, and includes a processor configured to take impedance measurements at the tip to confirm contact with the intra atrial septum and/or confirm entry into the left atrium.

Abstract: The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Current sensing techniques. In an example, a current sensing method includes: generating a first magnetic field measurement; generating a second magnetic field measurement; generating a frequency estimate of a current; calculating a root-mean-square (RMS) value of an estimated amplitude of the current; and generating a temperature estimate of an integrated circuit (IC) configured to perform the method. The method also includes generating a first weighting factor and a second weighting factor based on the frequency estimate, the RMS value, and the temperature estimate, the first weighting factor to control amplification of the first magnetic field measurement and the second weighting factor to control amplification of the second magnetic field measurement.