Abstract: A glass manufacturing apparatus can include a conduit connected to a delivery vessel and an inlet of a forming vessel. The conduit includes a closed sidewall surrounding a channel extending in a flow direction of the conduit. The closed sidewall is continuous from the delivery vessel to the inlet of the forming vessel to define a closed atmosphere from the delivery vessel, through the conduit, and through the inlet of the forming vessel. The glass manufacturing apparatus can include a heating enclosure including a heating wall and a first heating element. The heating wall surrounds a chamber within which the conduit extends. The first heating element is positioned within the chamber between the heating wall and the conduit to increase a temperature within the channel. Methods for manufacturing a glass ribbon with a glass manufacturing apparatus are provided.

Abstract: A depth sensing dilator system for dilating a penetration in a tissue plane includes an elongate flexible body, having a proximal end and a distal end. The body has a tapered dilator segment, and at least a first electrode on a distal end of the body. The system includes a processor and a user interface output device. The processor is configured to send a first signal to the output device when a change in impedance at the first electrode indicates that the first electrode has reached a predetermined relationship with the tissue plane.

Abstract: A transseptal crossing needle has an elongate, flexible tubular body, having a proximal end, a distal end and an electrically conductive sidewall defining a central lumen. The distal end has a radially inwardly extending annular recess. The tubular body has a first outside diameter proximally of the annular recess and a second, smaller outside diameter in the recess. An electrode tip has a proximally extending connector residing within the annular recess, and the electrode tip has a third outside diameter distally of the connector, which is greater than the first diameter. An insulation layer encloses the sidewall and the connector, and has an outside diameter approximately the same as the third diameter to provide a uniform outside diameter throughout a distal zone of the needle.

Abstract: A self-contained, battery powered transseptal crossing system is disclosed. An elongate, flexible electrically conductive needle body has a proximal end and a distal end. An insulation layer surrounds the sidewall and leaves exposed a distal electrode tip. A generator is configured to deliver RF energy to the electrode tip, and includes a processor configured to take impedance measurements at the tip to confirm contact with the intra atrial septum and/or confirm entry into the left atrium.

Abstract: An antenna with a heater and method for using the same are disclosed. The antenna may comprise: an antenna aperture having a plurality of radio-frequency radiating antenna elements, the antenna aperture having a ground plane and a material for tuning permittivity or capacitance; and a heater structure in thermal contact with the material.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: An apparatus for exchanging liquid crystal (LC) between two areas of an antenna array and method for using the same are disclosed. In one embodiment, the antenna comprises an antenna element array having a plurality of radiating radio-frequency (RF) antenna elements formed using portions of first and second substrates with a liquid crystal (LC) therebetween, and a structure between the first and second substrates and outside the area of the RF antenna elements to collect LC from an area between the first and second substrates forming the RF antenna elements due to LC expansion.

Abstract: Disclosed is a stabilizing retractor system for orthopedic fracture repair. A backing plate is configured to support the back of a wrist or ankle. At least a first soft tissue retractor includes a first support body having a first bone engaging concavity on a first side of the body on a distal portion of the body, configured to engage a first side of a bone. A first soft tissue retracting surface is provided on a second side of the body, proximal to the bone engaging concavity. A second soft tissue retractor may be provided for engaging a second side of the bone. The retractors may be pinned to the bone, and may be radiolucent.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: An orthodontic device can include a bracket configured to support an orthodontic wire. The orthodontic device can include a locking assembly coupled to the bracket and switchable between a plurality of operational modes. The plurality of operational modes can comprise a first sliding mode in which the orthodontic wire is slidable relative to the bracket and a second locked mode in which the orthodontic wire is slidably locked relative to the bracket.

Abstract: Routing and layout for an antenna are described. In one embodiment, the antenna comprises an aperture having a plurality of radio-frequency (RF) radiating antenna elements, wherein each antenna element of the plurality of RF radiating antenna elements comprises an iris slot opening and an electrode over the iris slot opening; a plurality of drive transistors coupled to the plurality of antenna elements; and a plurality of storage capacitors, each storage capacitor coupled to the electrode of one antenna element of the plurality of antenna elements. The aperture also comprises at least one of: the drive transistor for the one antenna element is located under the electrode of the antenna element, the storage capacitor for the one antenna element is located under the electrode of the antenna element, and the metal routing to the one antenna element for a first voltage overlaps, in an overlap region, a common voltage routing that routes the common voltage to the one antenna element to form a storage capacitance.

Abstract: Aspects of the disclosure relate to saddle type vehicles having at least one seat and at least two wheels, at least one electric motor, and a rechargeable electric energy storage system, such as a battery and battery management system. A vehicle seat may be mounted on an adjustable inner seat post, where the adjustable movement may be vertical, substantially vertical, or at least partially vertical. Vehicle handlebars may be mounted on an inner shaft which allows movement parallel to the steering axis and is indexed to an outer steering stem that allows the handlebars, a chassis fork and front wheel to be steered together. In some examples, the inner seat post and handlebar inner shaft are electronically raised and lowered, for example by one or more electrical stepper motors, such that position of handlebars and seat may be selected by rider.

Abstract: An antenna and method of using the same are described. In one embodiment, the antenna comprise an array of radio-frequency (RF) radiating antenna elements, wherein each RF radiating antenna element comprises a first conductor stack containing one or more metal layers and having a first set of one or more conductive layers covering a first side of the first conductive stack; a second conductor stack, separated from the first conductor stack, containing one or more conductive layers and having a second set of one or more conductive layers covering a second side of the second conductive stack; and liquid crystal (LC) between the first and second sides of the first and second conductor stacks, respectively.

Abstract: A method and apparatus for electrical addressing for an antenna (e.g., a metamaterial radio-frequency (RF) antenna are described. In one embodiment antenna comprising: a plurality of radio-frequency (RF) radiating antenna elements located in a plurality of rings; and matrix drive circuitry coupled to the plurality of RF radiating antenna elements to drive the antenna elements, wherein the matrix drive circuitry to uniquely address each of the antenna elements using a matrix of a plurality of rows and a plurality of columns with a non-grid-based addressing structure.

Abstract: An example system is configured for displaying enhancement options and financial analysis. The system may include a server, third party data sources and an augmented reality computing device that includes a processing unit and system memory. The augmented reality computing device is configured to obtain user input regarding a property enhancement option; render the property enhancement options in augmented reality; obtain financial data from the server and the third party data sources; responsive to the obtained user input, automatically generate a financial analysis of the property enhancement option, wherein the financial analysis is based on the obtained financial data; and render the financial analysis with the obtained property enhancement option in augmented reality.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Expansion compensation structures for an antenna are disclosed. In one embodiment, the antenna comprises: an array of antenna elements; and a structure coupled to the array of antenna elements, the structure having a plurality of components comprising materials having different coefficients of thermal expansion (CTEs), wherein first and second components of the plurality of components are pin bonded with one or more pins, and one or more components of the plurality of components other than the first and second components are between the first and second components and have one or more slots through which the one or more pins traverse and have CTEs different than CTEs of the first and second components.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.