Abstract: Systems and methods for conditionally performing engine operational tests for a turbine engine are provided. A system comprising at least one processor can be configured to obtain sensor data associated with at least one sensor for a turbine engine. The sensor data identifies a current fuel flow associated with the turbine engine. The system can determine a predicted fuel flow of the turbine engine based at least in part on the current fuel flow and a fuel flow reduction associated with an engine operational test. The system can compare the predicted fuel flow to at least one threshold. The system can selectively initiate the engine operational test based on comparing the predicted fuel flow to the at least one threshold.

Abstract: This invention relates to polynucleotides comprising optimized FIG4 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a FIG4 gene or aberrant activity of a FIG4 gene product in the subject, such as CMT4J.

Abstract: Some systems compress data utilized by a user mode software without the user mode software being aware of any compression taking place. To maintain that illusion, such systems prevent user mode software from being aware of and/or accessing the underlying compressed states of the data. While such an approach protects proprietary compression techniques used in such systems from being deciphered, such restrictions limit the ability of user mode software to use the underlying compressed forms of the data in new ways. Disclosed herein are various techniques for allowing user-mode software to access the underlying compressed states of data either directly or indirectly. Such techniques can be used, for example, to allow various user-mode software on a single system or on multiple systems to exchange data in the underlying compression format of the system(s) even when the user mode software is unable to decipher the compression format.

Abstract: The disclosed computer-implemented method may include tracking personal mobility vehicle batteries. In some embodiments, the method may track and maintain battery power for personal mobility vehicles to help to ensure that there are personal mobility vehicles with sufficient charge available to perform the needed transportation tasks within a dynamic transportation network. In some examples, a swappable battery for a personal mobility vehicle may communicate with a dynamic transportation management system and provide information about current and/or historical charge information. In some examples, the method may use the current state of charge and/or historical charge information to predict the performance of the battery. Based on the predicted performance, the method may predict the range of a personal mobility vehicles with the battery and/or a lifespan of the battery and make matching decisions accordingly. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treatment of neurodegenerative diseases and disorders, such as Alzheimer's disease.

Abstract: According to examples, an apparatus may include a memory on which is stored machine-readable instructions that may cause a processor to receive a user credential from a terminal, in which the user credential is stored in a machine-readable code on a user device and the terminal obtained the machine-readable code from the user device. The processor may also identify at least one authentication factor associated with the user based on the user credential, in which the authentication factor(s) includes a physical location associated with the user and/or a time-based factor. The processor may further determine whether the authentication factor(s) indicates that the user is to be granted access to the terminal and based on a determination that the authentication factor(s) indicates that the user is to be granted access to the terminal, may grant the user access to the terminal.

Abstract: Methods and apparatus are provided for optical coherence metrology or tomography across an extended area of an eye with improved registration. At least two optical coherence tomograms are acquired, with each tomogram containing data from regions of an anterior surface of the eye that are at least partially overlapping, and data from one or more deeper structures such as the retina or the anterior or posterior lens surfaces. The tomograms are then processed to register the data from the overlapping portions of the anterior surface regions, thereby registering the data from the deeper structures. In certain embodiments the reference arm of the apparatus comprises a compound reflector having at least two axially separated reflective surfaces for applying differential delays to different portions of the reference beam. The depth of field of the apparatus is thereby extended to enable measurement of eye length.

Abstract: The present invention relates to a hyperspectral apparatus and method. One aspect of the invention provides an apparatus for analyzing a sample. The apparatus comprises a light source configured to generate a broadband input irradiance field. The apparatus also comprises a structured light generator for converting the input irradiance field into a structured illumination field including an array of beamlets. An optical system projects the structured illumination field onto a region of the sample such as the retina. A spectrometer is configured to spectrally analyze a portion of light that is reflected, backscattered or fluoresced from the region of the sample. A processor is operatively associated with the spectrometer and configured to generate a hyperspectral image comprising two or more en-face images of the region of the eye. The en-face images include spectral response information of the sample from each beamlet of the structured illumination field.

Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: A robot arm comprising a joint mechanism for articulating one limb of the arm relative to another limb of the arm about two non-parallel rotation axes, the mechanism comprising: an intermediate carrier attached to a first one of the limbs by a first revolute joint having a first rotation axis and to a second one of the limbs by a second revolute joint having a second rotation axis; a first drive gear disposed about the first rotation axis, the first drive gear being fast with the carrier; a second drive gear disposed about the second rotation axis, the second drive gear being fast with the second one of the limbs; a first drive shaft for driving the first drive gear to rotate about the first rotation axis, the first drive shaft extending along the first one of the limbs and having a first shaft gear thereon, the first shaft gear being arranged to engage the first drive gear; a second drive shaft for driving the second drive gear to rotate about the second rotation axis, the second drive shaft extending along

Abstract: A chair comprises a seat pan member, a seat back member having a lumbar support member, a lumbar support assembly operatively connected to the lumbar support member and configured for moving the lumbar support member, with respect to the seat pan member and the seat back member, between at least a first position and a second position, and an actuator configured to operate the lumbar support assembly for movement of the lumbar support member between at least the first position and the second position. When the lumbar support member is in the second position, the lumbar support member is positioned forwardly, in a direction toward the seated user's lower back, relative to the seat back member so as to enable the user to be seated forwardly on the seat pan member while being engaged with the lumbar support member.

Abstract: This invention relates to polynucleotides comprising optimized CLN7 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of CLN7, such as variant late infantile neuronal ceroid lipofuscinoses (vLINCL; CLN7 disease).

Abstract: Electrical box assemblies are provided that have a support that is adjustable to different sizes. The electrical box assemblies provided also include a cable support that moves from a shipping position to an installed position.

Abstract: A system for securely depositing an item includes: a deposit box with a door configured to provide selective access to an interior space in the deposit box; a lock mechanism configured to attach to the deposit box to selectively block the door from opening; a first proximity sensor operatively connected to the lock mechanism to operate the lock mechanism to block the door or allow the door to open; a second proximity sensor configured to be attached to at least one of: a delivery person and a piece of delivery equipment; a third proximity sensor; and a first transmitter operatively connected to the lock mechanism and configured to transmit a signal indicative of operating information regarding the lock mechanism, and wherein the deposit box is at least 18 inches wide and 24 inches long.

Abstract: A robot arm comprising a joint mechanism for articulating one limb relative to another limb about two non-parallel rotation axes, the mechanism comprising: an intermediate carrier attached to a first one of the limbs by a first revolute joint having a first rotation axis and to a second one of the limbs by a second revolute joint having a second rotation axis; a first drive gear disposed about the first rotation axis and fast with the carrier, whereby rotation of the carrier relative to the first limb about the first rotation axis can be driven; a second drive gear disposed about the second rotation axis and fast with the second one of the limbs, whereby rotation of the second one of the limbs about the second rotation axis relative to the carrier can be driven; at least one of the first and second drive gears being a sector gear.

Abstract: A system includes an electronic control unit (ECU) including a processor that determines that the ECU has been communicably connected to a vehicle communication system. The processor sends a provisioning message, via the communication system, to a remote server, responsive to connection to the vehicle communication system. The message includes a vehicle identifier provided by an element of the vehicle system and signed with a unique security key specific to the ECU. The processor is also receives a confirmation response from the remote server and enables further communication for the ECU responsive to the confirmation response.

Abstract: An indexed cable arrangement can be installed in a re-enterable housing. The optical fibers of the cable are indexed between a first; ruggedized multi-fiber connector and a second multi-fiber connector. The second multi-fiber connector may be non-ruggedized and disposed within the housing (e.g., at an adapter) or ruggedized and disposed external of the housing (e.g., terminating a stub cable). One or more drop lines are terminated by respective non-ruggedized, single-fiber connectors disposed within the housing. In certain examples, drop lines may be split into multiple conneaorized single-fiber outputs.

Abstract: The disclosed computer-implemented method may include automated signaling for networked personal mobility vehicles (PMVs). In some embodiments, a system may identify a PMV in use by a transportation requestor taking a trip. The system may also predict one or more actions of the PMV based on navigational data for the trip. Additionally, the system may select one or more signals corresponding to a predicted action of the PMV. In some embodiments, the system may determine, based on a current state of the PMV, that the predicted action of the PMV will be initiated within a time frame. Furthermore, the system may send a start command to the PMV to initiate a signal in response to determining the predicted action will be initiated. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.