Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.

Abstract: A water sorption device includes a catalytic combustor configured to, in a desorption state, combust a hydrocarbon fuel mixture to generate heat; a thermoelectric generator configured to, in the desorption state, generate electricity from a first portion of the heat from the catalytic combustor; and an adsorber configured to in an adsorption state, adsorb water from ambient air from an environment and in the desorption state, desorb the adsorbed water as vapor using a second portion of the heat from the catalytic combustor.

Abstract: The disclosed computer-implemented method may include matching transportation requests to personal mobility vehicles. A dynamic transportation network may incorporate different types of vehicles, such as bicycles and/or scooters. Certain vehicles may have advantages over other vehicles in certain contexts but be disadvantageous in others. For example, a dynamic transportation matching system may match a user transporting a bulky package with a basket-equipped bike rather than a scooter without a basket. Moreover, the dynamic transportation matching system may account for a wide variety of other factors, including but not limited to route features, ambient conditions, and vehicle status when matching a transportation requestor to a specific vehicle. Moreover, some systems may account for vehicle wear-and-tear, battery power levels, operational status, etc. to avoid matching users vehicles that would be unable to fulfill a transportation request.

Abstract: A robotic surgical instrument comprising a shaft, an articulated section and a drive mechanism. The articulated section extends from the shaft and terminates at its distal end in a tip. The tip has an attachment for an end effector. The drive mechanism drives the articulated section via flexible driving elements thereby altering the angular orientation of the tip relative to the shaft. The drive mechanism is controlled so as to always fully compress the articulated section along at least one extent by which the articulated section connects the tip and the shaft whilst driving the articulated section from any one configuration to any other configuration. The drive mechanism constrains movement of the articulated section so as to permit the tip to move with two degrees of rotational freedom and no degrees of translational freedom relative to the shaft.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products for linking to a search result. A computing system receives a query and provides, to a first computing device, multiple results that are responsive to the query. The computing system provides, to the first computing device, information that identifies a web address of a user selected result of multiple results that are responsive to query. The computing system receives a request from a second computing device for content responsive to the web address of the user selected result. The computing system provides, to the second computing device, information to cause the second computing device to present the multiple results that are responsive to the query in distinction to the user selected result, responsive to the second computing device not being authorized to access the user selected result.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Systems and methods for conditionally performing engine operational tests for a turbine engine are provided. A system comprising at least one processor can be configured to obtain sensor data associated with at least one sensor for a turbine engine. The sensor data identifies a current fuel flow associated with the turbine engine. The system can determine a predicted fuel flow of the turbine engine based at least in part on the current fuel flow and a fuel flow reduction associated with an engine operational test. The system can compare the predicted fuel flow to at least one threshold. The system can selectively initiate the engine operational test based on comparing the predicted fuel flow to the at least one threshold.

Abstract: The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: This invention relates to polynucleotides comprising optimized CLNS open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLNS gene or aberrant activity of a CLNS gene product in the subject, such as CLNS disease.

Abstract: Systems, methods, and devices for retrying a query. The method includes receiving from a client a query directed to database data stored on a database platform the query being received by a first component of the database platform. The method includes making by the first component an attempt to execute the query and based on determining that the attempt to execute the query was unsuccessful, the first component sending a query retry job to a second component of the database platform. The method includes selecting by the second component based at least in part on the indicated version of the database platform a version of the database platform on which to attempt a first retry attempt to execute the query.

Abstract: The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A system for securely depositing an item includes: a deposit box with a door configured to provide selective access to an interior space in the deposit box; a lock mechanism configured to attach to the deposit box to selectively block the door from opening; a first proximity sensor operatively connected to the lock mechanism to operate the lock mechanism to block the door or allow the door to open; a second proximity sensor configured to be attached to at least one of: a delivery person and a piece of delivery equipment; a third proximity sensor; and a first transmitter operatively connected to the lock mechanism and configured to transmit a signal indicative of operating information regarding the lock mechanism, and wherein the deposit box is at least 18 inches wide and 24 inches long.

Abstract: A process for the production of heterocyclic quaternary ammonium salts or hydroxides is disclosed. The process comprises a continuous hydrogenation step, in which an unsaturated heterocyclic amine is reacted with hydrogen to form a saturated heterocyclic amine; a first continuous N-alkylation step, in which the saturated heterocyclic amine is alkylated to produce an intermediate saturated heterocyclic amine having an increased degree of substitution compared to the saturated heterocyclic amine; and one or more further N-alkylation steps in which the intermediate saturated heterocyclic amine is N-alkylated to the heterocyclic quaternary ammonium salt or hydroxide. A process of producing a saturated heterocyclic amine is also disclosed. The process comprises reacting an unsaturated heterocyclic amine with hydrogen in a vapour phase reaction at a pressure of not more than 70 bar and a temperature in the range of from 150° C. to 350° C. A process of N-alkylating a saturated heterocyclic amine is also disclosed.

Abstract: Apparatus and methods are presented for non-contact in-vivo measurement of one or more properties of a cornea or tear film with spatial resolution. In certain embodiments the cornea/tear film is probed at substantially normal incidence with a converging array of beamlets from a multi-wavelength optical source, and the reflected light analysed interferometrically to generate a time sequence of pachymetry maps. Thickness variations arising from differences between the external and intraocular pressure, e.g. from the ocular pulse or externally applied pressure changes, are measured and analysed to obtain information on a biomechanical response of the cornea. In preferred embodiments the time variation in tear film thickness is measured and subtracted to yield normalised pachymetry data for the biomechanical analysis. In certain embodiments the apparatus is configured to measure the dynamics and profile of the tear film, using either converging or substantially parallel arrays of beamlets.

Abstract: A chair includes a seat pan member, a movement support frame, and at least two movement support members operatively connected to the seat pan member and the movement support frame. The at least two movement support members are configured to support the seat pan member in a floating manner for dynamic movement with respect to the movement support frame in at least one degree of freedom in a horizontal seating plane.

Abstract: The present disclosure relates to apparatuses and methods for adjusting and maintaining a position of cutting surfaces used to create lines of weakness in rolled products. During cutting operations, intermittent contact between cutting surfaces causes cutting components to become heated, which in turn, causes an overlap distance between cutting surfaces to vary from desired values. Conversely, when cutting operations are stopped, the components cool, which in turn, may cause the overlap distance to vary from desired values at steady state operating conditions. To help reduce or eliminate the changes to overlap distances caused by cyclical heating and cooling between times of cutting operations and shutdowns, one or more heaters may be utilized to apply heat to one or more components to maintain relatively constant temperatures during periods of cutting operations and/or when cutting operations are paused or stopped.

Abstract: An authentication server may not support all types of user credentials. For example, an on-premise authentication server may support credentials based on user secrets (i.e. username and password) and certificate-based credentials, but not hardware-key based credentials. A client device may use an un-supported type of credential to access resources managed by the on-premise authentication server by authenticating with a web-based authentication server. The web-based authentication server may support any type of credential, and the supported types of credentials may change over time. The web-based authentication server returns an authenticated user token indicating the user has been authenticated, but without authorizing access to any resources. The client device uses the on-premise authentication server to exchange the authenticated user token for an authorized user token. The client device then uses the authorized user token to access resources on the on-premise network.

Abstract: Geomechanical parameters can be used to optimize a well configuration that includes one or more projected wells having locations and geometries. Formation data and regional stress information of a formation can be used to determine a local stress variation of the formation. A quality index can be generated by combining petrophysical properties with the local stress variation. Hydrocarbon recovery flow simulations can be generated by generating well configuration models based on the quality index, generating reservoir geomechanical model that includes hydraulic fracture propagation characteristics, determining new hydraulic fractures by simulating propagation through the reservoir geomechanical model and using geomechanical rules, and determining a projected hydrocarbon recovery rate by simulating flow with the new hydraulic fractures. A well placement plan can be selected using the projected hydrocarbon recovery rates. The well placement plan can be output to be used to plan one or more wellbores.

Abstract: Provided are compounds of formula (III), and the use of compounds of formula (III) in methods of treatment, such as methods of treating a microbial infection. The compounds of formula (III) is: where —R15 is an amino-containing group: and —R1, —R2, —R3, —R4, —R, —RA, Q, —R16, —R17 are as described in further detail in the description.