Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: Systems, methods, and devices for retrying a query. A method includes receiving a query directed to database data and assigning execution of the query to one or more execution nodes of an execution platform, the one or more execution nodes configured to execute the query on a first version of a database platform. The method includes determining that execution of the query was unsuccessful. The method includes assigning a first retry execution of the query to the one or more execution nodes of the execution platform and determining whether a regression or an intermittent fault caused the execution of the query to be unsuccessful based at least in part on whether the first retry execution of the query was successful or unsuccessful.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A system for securely depositing an item includes: a deposit box with a door configured to provide selective access to an interior space in the deposit box; a lock mechanism configured to attach to the deposit box to selectively block the door from opening; a first proximity sensor operatively connected to the lock mechanism to operate the lock mechanism to block the door or allow the door to open; a second proximity sensor configured to be attached to at least one of: a delivery person and a piece of delivery equipment; a third proximity sensor; and a first transmitter operatively connected to the lock mechanism and configured to transmit a signal indicative of operating information regarding the lock mechanism, and wherein the deposit box is at least 18 inches wide and 24 inches long.

Abstract: Pumping and water distribution systems for pools/spas, and methods for control thereof are provided. A system includes a pump including a variable speed motor, a controller configured to control the speed of the motor, a plurality of pool/spa components, a plumbing subsystem placing the components in fluidic communication with the pump, and a plurality of control valves switchable between an open position and a closed position. Each of the control valves is associated with one of the components, positioned in the plumbing subsystem between the associated component and the pump to control the flow of fluid to the associated component, and is configured to provide a specific flow rate of fluid to the associated component based on a set system pressure when in the open position. The controller adjusts the speed of the motor to adjust the fluid pressure within the plumbing subsystem to match the set system pressure value.

Abstract: The disclosed computer-implemented method may include improving safety in operating personal mobility vehicles. The method may track and/or control personal mobility vehicles associated with dynamic transportation networks. The method may improve safety related to PMV operation by taking advantage of the various sources and types of information related to PMV operation that are available in the dynamic transportation network. Other methods, systems, and computer-readable media are disclosed.

Abstract: A surface cleaning apparatus is described including a housing supporting a suction source, a dirt collection container, and a cyclonic separation device for separating dirt from the airflow passing through the apparatus. The apparatus further includes a ducting member having an inlet in communication with an outlet from the cyclonic separation device and an outlet in communication with a passage leading to the suction source. The ducting member is removably connected to the housing or the dirt collection container and is rotatably moveable between locked and unlocked positions, and rotational movement of the ducting member from its unlocked position to its locked position aligns the outlet of the ducting member with the passage leading to the suction source.

Abstract: Methods and apparatus are presented for obtaining high-resolution 3-D images of a sample over a range of wavelengths, optionally with polarisation-sensitive detection. In preferred embodiments a spectral domain OCT apparatus is used to sample the complex field of light reflected or scattered from a sample, providing full range imaging. In certain embodiments structured illumination is utilised to provide enhanced lateral resolution. In certain embodiments the resolution or depth of field of images is enhanced by digital refocusing or digital correction of aberrations in the sample. Individual sample volumes are imaged using single shot techniques, and larger volumes can be imaged by stitching together images of adjacent volumes.

Abstract: Techniques for automated query retry in a database platform include decoding, by at least one hardware processor, a query directed to database data from a client account of a database platform. The method further includes decoding, by the at least one hardware processor, an indication that execution of the query on at least one computing node of the database platform results in a failed execution. The method further includes configuring a processing loop with continuous retry executions of the query on the at least one computing node based on the indication. The method further includes exiting the processing loop based on detecting a retry execution of the continuous retry executions results in at least one successful execution of the query. The method includes logging each attempt to execute the query during the continuous retry executions in a query status log until the at least one successful execution of the query.

Abstract: A display includes two-integrated cameras. A first camera is situated in a top right corner of a front display surface of the display and a second camera is situated in a top left corner of the front display surface. The display is connected to a transaction terminal with the first camera focused on a bagging area associated with the transaction terminal and with the second camera focused on a staging area associated with the transaction terminal. Each camera captures images of items and the item images are streamed over a high-speed display port directly to the transaction terminal. The transaction terminal performs item recognition, item tracking, and auditing on the items based the item images during transaction processing at the transaction terminal.

Abstract: An electrical box assembly having an electrical box and a cable connector is provided. The cable connector includes a mounting bracket cable retaining member and a cable stop. The mounting bracket is secured to or integral with a side wall of the electrical box. The cable retaining member is secured to the mounting bracket and has a cable gripping portion extending into a cable receiving zone of the box. The cable stop extends from a bottom wall of the electrical box into the cable receiving zone. The cable stop permits one or more electrical wires from an electrical cable to pass through the cable stop while blocking sheathing of the electrical cable from passing through the cable stop.

Abstract: A waterproof light bulb assembly implements a plurality of light emitting diodes (LEDs) for use in light fixture in an outdoor or wet environment. The light bulb assembly includes a plastic bulb shell which used a threaded portion to mate to a bulb cap. The bulb cap includes a passage to receive a light emitting assembly having a direct current (DC) connector. The light emitting assembly includes the plurality of LEDs and a printed circuit board. A switching circuit regulates current and heat emitted by the plurality of LEDs. The light bulb assembly also includes a socket to receive the plastic bulb shell and bulb cap.

Abstract: A system includes an electronic control unit (ECU) including a processor that determines that the ECU has been communicably connected to a vehicle communication system. The processor sends a provisioning message, via the communication system, to a remote server, responsive to connection to the vehicle communication system. The message includes a vehicle identifier provided by an element of the vehicle system and signed with a unique security key specific to the ECU. The processor is also receives a confirmation response from the remote server and enables further communication for the ECU responsive to the confirmation response.

Abstract: A faucet-mounted filter system includes a body forming a fluid chamber having a water inlet, a quick connect device positioned adjacent the water inlet for mounting the filter system to a water faucet, a filtered water flow path disposed within the body and in fluid communication with the water inlet, an unfiltered water flow path disposed within the body and in fluid communication with the water inlet, a diverter valve disposed within the fluid chamber and operable to open and close the filtered and unfiltered water flow paths, a seal, an actuator engaging the diverter valve to open and close the filtered and unfiltered water flow paths, a flow meter connected to the body and in fluid communication with the filter flow path, a filter housing connected to the body and having a reservoir, and a filter cartridge disposed within the reservoir.

Abstract: A method for simultaneous filtration and non-discharge backwash operation of a pool filter. Water is received from a pool of water and passed to a control valve having a backwash nozzle aligned with a first filtration chamber. The water is forced down through all of the filtration chambers except the first filtration chamber and forced up through the first filtration chamber. The backwash nozzle is aligned with a second filtration chamber. The water is forced down through all of the filtration chambers except the second filtration chamber and forced up through the second filtration chamber. The water is passed through the backwash nozzle and an internal backwash valve to a sedimentation collection and separation system, where sediment is settled out of the water and the water is filtered through a final filtration media within the final filtration chamber. The water is returned to the pool of water.

Abstract: A pool filter system comprising a plurality of filtration chambers configured to filter pool water, a water supply inlet, a water return line, and a control valve. The water supply inlet is configured to receive unfiltered water from a pool of water. The water return line is configured to return filtered water to the pool of water. The control valve receives water from the water supply inlet. The control valve has a backwash nozzle configured to rotate and sequentially align with each of the plurality of filtration chambers. The backwash nozzle has a first position aligned with a first filtration chamber and a second position aligned with a second filtration chamber. The control valve is configured to backwash water through the first filtration chamber when the backwash nozzle is in the first position and through the second filtration chamber when the backwash nozzle is in the second position.

Abstract: An information transmission method and a related device are provided. The method includes: determining, by a base station, to send downlink information to P user equipments of at least one user equipment within a first time period; generating, by the base station, an indication field according to the determined P user equipments, where the indication field includes M bits, each of the at least one user equipment is corresponding to K bits of the M bits, the K bits are used to indicate whether the corresponding user equipment needs to receive and read the downlink information sent by the base station within the first time period, K is a positive integer greater than 1 and less than M, and P is an integer greater than or equal to 0; and sending, by the base station, the indication field to the at least one user equipment.

Abstract: Techniques for automated query retry in a database platform include assigning by at least one hardware processor a first execution of a query directed to database data to a first execution node of a plurality of execution nodes of an execution platform. The first execution node uses a first set of configurations during the first execution. The techniques further include determining that the first execution of the query by the first execution node results in a failed execution. The query is transferred to a second execution node of the plurality of execution nodes. A second execution of the query at the second execution node is caused. The second execution node uses a second set of configurations during the second execution. A cause of the failed execution at the first execution node is determined based on a result of the second execution of the query at the second execution node.